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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 1–60 of 90 studies · page 1/2fasciaSince 2015
Clear
A++2023

Change in gliding properties of the iliotibial tract in hypermobile Ehlers–Danlos Syndrome

Tina J Wang, Antonio Stecco, Robert Schleip, Carla Stecco, Carmelo Pirri

This study used ultrasonography to examine the gliding properties of the iliotibial tract (ITT) in individuals with hypermobile Ehlers-Danlos Syndrome (hEDS). Researchers found that the shear strain, which represents ho…

fasciashear strainultrasonography
A+++2021

Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism

Brian Tuckey, John Srbely, Grant Rigney, Meena Vythilingam, Jay Shah

In this theoretical paper, the authors propose a potential mechanism for chronic pain syndromes. They hypothesize that impaired lymphatic drainage following trauma or an immune response can trap inflammatory substances…

fasciacytokinesinterstitial inflammatory stasis
A2021

Fascial Nomenclature: Update 2021, Part 2

Bruno Bordoni, Allan R Escher, Filippo Tobbi, Bruno Ducoux, Serge Paoletti

This conceptual article addresses the ongoing debate about how to classify and name fascia. The authors suggest that progress is hindered because the discussion is often limited to a few scientific specialties and can b…

fasciafascial systemOsteopathic
A2021

Fascial Nomenclature: Update 2021, Part 1

Bruno Bordoni, Allan R Escher, Filippo Tobbi, Antonio Pranzitelli, Luigi Pianese

This review article discusses the need for clear, scientifically grounded terminology for the fascial system. The authors, representing the FORCE organization, emphasize the importance of an impartial approach to fascia…

fasciafascial systemOsteopathic
A++2020

Fascia and soft tissues innervation in the human hip and their possible role in post-surgical pain

Caterina Fede, Andrea Porzionato, Lucia Petrelli, Chenglei Fan, Carmelo Pirri, Carlo Biz, Raffaele De Caro, Carla Stecco

Researchers investigated the nerve supply to various soft tissues in the human hip to better understand persistent pain after hip replacement surgery. Analyzing tissue samples from patients and cadavers, they measured t…

fasciapaininnervation
A+++2020

A Review of the Theoretical Fascial Models: Biotensegrity, Fascintegrity, and Myofascial Chains

Bruno Bordoni, Tom Myers

In this review article, the authors discuss three theoretical models used to understand how fascia functions in the body. The biotensegrity model is mechanical and considers the solid fascia, while the fascintegrity mod…

fasciaMyofascialOsteopathic
A2020

Anatomy, Tendons

Bruno Bordoni, Matthew Varacallo

This is a placeholder for a summary of a publication titled "Anatomy, Tendons". The full text has not yet been reviewed by our team. Once summarized, this entry will provide an overview of the key anatomical features of…

fasciatendonsAnatomy
A+++2020

The Five Diaphragms in Osteopathic Manipulative Medicine: Myofascial Relationships, Part 2

Bruno Bordoni

This conceptual review article continues an examination of the "five diaphragms" concept within osteopathic manipulative medicine. The paper focuses on the myofascial connections along the front and sides of the body, e…

fasciaMyofascialOsteopathic
A+++2020

The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 2

Bruno Bordoni, Stevan Walkowski, Bruno Ducoux, Filippo Tobbi

This narrative review, the second in a series, discusses how modern scientific research challenges some of the original concepts of cranial osteopathy. The authors examine the mechanical characteristics of cranial struc…

fasciaManual TherapyOsteopathic
A+2020

Ankle Motion Is Associated With Soft Tissue Displacement in the Dorsal Thigh: An in vivo Investigation Suggesting Myofascial Force Transmission Across the Knee Joint

Jan Wilke, Heloise Debelle, Sarah Tenberg, Andrew Dilley, Constantinos Maganaris

This study investigated how ankle motion affects tissue in the back of the thigh. Researchers passively stretched the calves of healthy participants lying prone with an extended knee. Using ultrasound, they observed tha…

fasciamyofascial chainsultrasound.
A2020

Ageing of the diaphragm muscle

Bruno Bordoni, Bruno Morabito, Marta Simonelli

This narrative review explores how the diaphragm, our main breathing muscle, is affected by aging. Like other muscles, the diaphragm can weaken and lose mass over time, a condition known as sarcopenia. This age-related…

fasciadiaphragmskeletal muscle
A++2020

Ultrasound imaging of a scar on the knee: Sonopalpation for fascia and subcutaneous tissues

Carmelo Pirri, Antonio Stecco, Caterina Fede, Raffaele De Caro, Carla Stecco, Levent Özçakar

Persistent pain from surgical or trauma-related scars is a common and sometimes debilitating problem. In this article, the authors describe the use of ultrasound imaging to provide an objective diagnosis for debilitatin…

fasciapainscar
A+++2020

The Five Diaphragms in Osteopathic Manipulative Medicine: Myofascial Relationships, Part 1

Bruno Bordoni

This review article outlines the osteopathic concept of the body's "five diaphragms": the tentorium cerebelli, tongue, thoracic outlet, respiratory diaphragm, and pelvic floor. According to the osteopathic respiratory-c…

fasciaMyofascialOsteopathic
A2020

Reflections on the Development of Fascial Tissue: Starting from Embryology

Bruno Bordoni, Bruno Morabito

This reflective article discusses the ongoing challenges in classifying fascial tissue. The authors highlight that the scientific literature contains many contradictions and lacks a clear, straightforward definition. Th…

fasciaMyofascialSurgery
A+++2020

The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 1

Bruno Bordoni, Stevan Walkowski, Bruno Ducoux, Filippo Tobbi

In this review article, the first of a two-part series, the authors examine the foundational assumptions of cranial osteopathy. They argue that a theoretical model must evolve with new scientific information to avoid be…

fasciaOsteopathicdiaphragm
A+++2020

The immediate effect of IASTM vs. Vibration vs. Light Hand Massage on knee angle repositioning accuracy and hamstrings flexibility: A pilot study

George A Koumantakis, Eleonora Roussou, Georgios A Angoules, Nikolaos A Angoules, Theodoros Alexandropoulos, Georgia Ma…

This pilot study compared the immediate effects of three different soft tissue techniques on the hamstrings of 16 healthy men. The techniques were instrument-assisted soft tissue mobilization (IASTM), vibration massage,…

fasciaproprioceptionMassage
A+++2019

Tentorium Cerebelli: Muscles, Ligaments, and Dura Mater, Part 1

Bruno Bordoni, Marta Simonelli, Maria Marcella Lagana

In this narrative review, the authors describe the anatomy of the tentorium cerebelli, part of the reciprocal tension membranes that divide areas of the brain. They highlight its connections to the dura mater, ligaments…

fasciafascial systemdura mater
1A++2019

Evaluation of hyaluronan content in areas of densification compared to adjacent areas of fascia

E J Hughes, K McDermott, M F Funk

This entry is currently a title only, so a full summary is not available. Based on the title, the researchers appear to have evaluated and compared the hyaluronan content in areas of fascial densification with the conte…

hyaluronanfasciadensification
A++2019

The architecture and spatial organization of the living human body as revealed by intratissular endoscopy - An osteopathic perspective

Colin Armstrong

This review article discusses research by Dr. Jean-Claude Guimberteau, who used endoscopy to visualize the internal architecture of the living body. His work reveals a continuous, body-wide multifibrillar network that t…

fasciaextracellular matrixosteopathy
1A+2019

The fascial breath

Bruno Bordoni, Marta Simonelli, Bruno Morabito

This narrative review proposes a new way of understanding the diaphragm muscle, moving beyond a purely mechanical view. The authors argue that the diaphragm is not just covered by fascia but is fundamentally a fascial t…

fasciaMyofascialOsteopathic
A+++2019

Tentorium Cerebelli: the Bridge Between the Central and Peripheral Nervous System, Part 2

Bruno Bordoni, Marta Simonelli, Maria Marcella Lagana

This article, the second in a series, describes the tentorium cerebelli—a meningeal structure related to the skull, nervous system, and cervical spine. The authors discuss its complex relationships, including its neurol…

fasciapaincranio
A2019

Biotensegrity or Fascintegrity

Bruno Bordoni, Matthew A Varacallo, Bruno Morabito, Marta Simonelli

In this theoretical review, the authors question the popular "biotensegrity" model for describing the body's mechanics. They argue the model is incomplete because it fails to account for crucial factors like bodily flui…

fasciaMyofascialOsteopathic
A2019

Lymphatic pump manipulation in patients with chronic obstructive pulmonary disease

Bruno Bordoni

This narrative review examines the use of lymphatic pump manipulation for patients with chronic obstructive pulmonary disease (COPD). COPD is characterized by persistent inflammation, and lymphatic techniques aim to red…

inflammationfasciaOsteopathic
A2019

Cranial osteopathy: Obscurantism and Enlightenment

Bruno Bordoni, Bruno Morabito, Marta Simonelli

In this reflective article, the authors discuss the controversial aspects of cranial osteopathy. They address common objections, such as the idea that the cranial bones are immobile in adults and that an operator's hand…

fasciaOsteopathicquantum physics
1A+2019

The Other Side of the Fascia: Visceral Fascia, Part 2

Bruno Bordoni, Marta Simonelli, Bruno Morabito

This editorial, part two of a series, argues for including certain internal organs (viscera) within the definition of fascia. From an osteopathic perspective, the authors suggest that understanding these organs as fasci…

fasciaMyofascialOsteopathic
A2019

Fascial Nomenclature: An Update

Bruno Bordoni, Stevan Walkowski, Bruno Morabito, Matthew A Varacallo

This review article discusses the ongoing challenge of creating a single, comprehensive definition for fascia. The authors argue that different scientific and clinical fields view fascia through their own unique lenses,…

fasciamechanotransductionMyofascial
1A+2019

Bone Tissue is an Integral Part of the Fascial System

Bruno Bordoni, Maria Marcella Lagana

This review article proposes that bone tissue should be considered an integral part of the fascial system, a departure from the current definition. The authors support this by highlighting the shared embryological origi…

fasciaBonefascial system
A2019

Improving the New Definition of Fascial System

Bruno Bordoni

This narrative review proposes expanding the definition of the fascial system to include bone tissue. The author argues that bone, a specialized form of connective tissue, shares the same embryological origins as other…

fasciaChiropracticosteopathy
1A+2019

Role of fasciae in nonspecific low back pain

G Casato, Carla Stecco, R Busin

Research increasingly links the thoracolumbar fascia to non-specific low back pain. This small case study explored the idea that pain could originate elsewhere in the body's continuous fascial network. Five patients wit…

fascianonspecific low back painlimb myofascial manipulation
1A+2019

Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production

Caterina Fede, Carmelo Pirri, Chenglei Fan, Giovanna Albertin, Andrea Porzionato, Veronica Macchi, Raffaele De Caro, Ca…

Women experience myofascial pain more often than men, and evidence suggests fascia can be influenced by sex hormones. In this lab study, researchers examined how cells from human fascia lata responded to various levels…

fasciacollagen Icollagen III
A2019

The diaphragm muscle manual evaluation scale

Bruno Bordoni, Bruno Morabito

This technical report describes a new method for manually assessing the diaphragm's function, called the Manual Evaluation Diaphragm (MED) scale. The scale is designed to generate a value for the respiratory muscle's mo…

fasciaMyofascialdiaphragm
1A+2019

The Other Side of the Fascia: The SmoothMuscle Part 1

Bruno Bordoni, Marta Simonelli, Bruno Morabito

This theoretical article challenges the standard definition of fascia. Traditionally, fascia is considered connective tissue originating from two embryonic layers, the mesoderm and ectoderm. The authors propose expandin…

fasciaMyofascialOsteopathic
1A+2019

The Awareness of the Fascial System

Bruno Bordoni, Marta Simonelli

In this theoretical article, the authors propose a new way of looking at the fascial system, drawing on concepts from quantum physics. They suggest that fascial cells can sense, remember, and even anticipate mechanical…

fasciafascial systemMyofascial
A2019

Anatomy, Fascia

Bruno Bordoni, Navid Mahabadi, Matthew Varacallo

This resource provides an overview of the anatomy of fascia. As the full text has not yet been reviewed, this summary is based on the title alone. The entry likely covers the structural and functional aspects of fascial…

fascia
C2018

Anatomy of the fasciae and fascial spaces of the maxillofacial and the anterior neck regions

Seiichiro Kitamura

This narrative review simplifies the complex anatomy of the fascia in the face, jaw, and front of the neck. The author organizes the region into four distinct portions based on their relationship to a key fascial layer,…

fasciaFascial spaceGross anatomy
A++2018

Bone is fascia

Stephen Levin

This entry, based on its title alone, proposes a conceptual link between bone and fascia. Without an abstract or full text, the specific arguments made by the author remain unclear. The title 'Bone is fascia' suggests a…

fascia
A2018

Meaning of the Solid and Liquid Fascia to Reconsider the Model of Biotensegrity

Bruno Bordoni, David Lintonbon, Bruno Morabito

This theoretical article proposes a reconsideration of the traditional biotensegrity model. The authors argue that fascia should be viewed as a system with both solid and liquid components, where blood and lymph constit…

fasciaChiropracticManual Therapy
A2018

A New Concept of Biotensegrity Incorporating Liquid Tissues: Blood and Lymph

Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna

This conceptual article proposes an update to the biotensegrity model, which traditionally focuses on the solid structures of the fascial system. The authors argue that "liquid tissues" like blood and lymph should also…

fasciaChiropracticManual Therapy
A2018

New Proposal to Define the Fascial System

Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna, Beatrice Sacconi, Paul Mazzucco

In this proposal, the authors suggest a new definition for the fascial system, noting that a universally accepted one does not yet exist. They argue for including the epidermis (the outer layer of skin) based on functio…

fasciaConnective tissuefibroblast
1A+2018

The Fasciacytes- A New Cell Devoted To Fascial Gliding Regulation

Carla Stecco, Caterina Fede, Veronica Macchi, Andrea Porzionato, Lucia Petrelli, Carlo Biz, Robert Stern, Raffaele De C…

Researchers have identified a new type of cell within fascia, which they have named "fasciacytes." This study presents evidence that these specialized cells are responsible for producing hyaluronan, a key component of t…

hyaluronanfasciafasciacytes
A2018

The anatomical relationships of the tongue with the body system

Bruno Bordoni, Bruno Morabito, Roberto Mitrano, Marta Simonelli, Anastasia Toccafondi

In this review article, the authors examine the tongue's functions and its anatomical connections to the rest of the body. The tongue is not only essential for swallowing, breathing, and speaking, but it also affects po…

fasciadiaphragmphysiotherapy
A2018

Immediate effects of self-myofascial release on latent trigger point sensitivity: a randomized, placebo-controlled trial

Jan Wilke, Lutz Vogt, Winfried Banzer

This randomized, placebo-controlled trial examined whether foam rolling could immediately reduce sensitivity in latent trigger points. Researchers compared 90 seconds of static compression, dynamic rolling, and a placeb…

fasciaMyofascial painFoam rolling
1A+++2018

Emission of Biophotons and Adjustable Sounds by the Fascial System: Review and Reflections for Manual Therapy

Bruno Bordoni, F Marelli, B Morabito, B Sacconi

In this narrative review, the authors explore how fascia, the web of connective tissue enveloping everything in the body, might communicate. They discuss research suggesting the fascial system may emit faint light parti…

fasciaMuscleManual Therapy
A2018

Fasciae of the musculoskeletal system: normal anatomy and MR patterns of involvement in autoimmune diseases

Thomas Kirchgesner, Xavier Demondion, Maria Stoenoiu, Patrick Durez, Adrien Nzeusseu Toukap, Frédéric Houssiau, Christi…

This review article describes the fascial system as a three-dimensional continuum of connective tissue found throughout the body. The authors review the normal anatomy of fascia and its appearance on magnetic resonance…

fasciaMusculoskeletalAnatomy
A2018

Chest pain in patients with COPD: the fascia’s subtle silence

Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna

In this article, the authors discuss potential causes of chest pain in patients with chronic obstructive pulmonary disease (COPD). They highlight that chest pain is common in COPD and propose that an often-overlooked so…

fasciadiaphragmmuscle pain
A2018

Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?

Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David Lintonbon

In this review paper, the authors discuss fibromyalgia, a chronic pain condition whose cause remains uncertain. While often linked to changes in the central nervous system, research also points to peripheral nerve damag…

fasciaFibromyalgiapain
A+++2018

Fascial tissue research in sports medicine: from molecules to tissue adaptation, injury and diagnostics: consensus statement

Martina Zügel, Constantinos N Maganaris, Jan Wilke, Karin Jurkat-Rott, Werner Klingler, Scott C Wearing, Thomas Findley…

This consensus statement reviews the current state of knowledge on fascial tissue in sports medicine. It describes fascia as a body-wide network of connective tissue that integrates all body systems and is crucial for m…

fasciainjurysports medicine
A2018

Frontiers in fascia research

Carla Alessandra Avila Gonzalez, Mark Driscoll, Robert Schleip, Scott Wearing, Eric Jacobson, Thomas Findley, Werner Kl…

This article reviews recent developments in fascia research, emphasizing new ways to assess this highly variable tissue. Researchers note that fascia differs greatly between individuals in density, stiffness, and metabo…

fasciaultrasound.Pain therapy
1A+2018

Effect of Stretching on Thoracolumbar Fascia Injury and Movement Restriction in a Porcine Model

H M Langevin, J Bishop, R Maple, G J Badger, J R Fox

In this animal study on pigs, researchers investigated the effect of stretching on the thoracolumbar fascia after injury and movement restriction. An injury combined with restricted movement led to reduced fascial mobil…

fasciaConnective tissueStretching
A2017

The indeterminable resilience of the fascial system

Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice Sacconi

This commentary proposes a model of fascia not as layers, but as a network of polyhedral microvacuoles of connective tissue. These structures connect the body's systems and can change shape in response to tension, allow…

fasciafibroblastManual Therapy
A2017

The Lumbodorsal Fascia as a Potential Source of Low Back Pain: A Narrative Review

Jan Wilke, Robert Schleip, Werner Klingler, Carla Stecco

This narrative review examines the role of the lumbodorsal fascia as a potential source of low back pain. Research shows this fascia contains pain-sensing nerve endings, which may be morphologically altered in people wi…

fasciaNociceptionlow back pain
1A+2017

Emotions in Motion: Myofascial Interoception

B Bordoni, F Marelli

In this perspective piece, the authors argue that the myofascial system is closely linked to our emotional state. They suggest that manual treatment not only affects the body physically but also activates the interocept…

fasciaManual TherapyMyofascial
C2017

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface

KA Khan, AJ Naylor, A Khan, PJ Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, CD Buckley, BE Willcox, F Mohammed ,…

Researchers investigated how certain proteins interact to form new blood vessels, a process called angiogenesis that is crucial for tumor growth. This study, which included lab experiments and mouse models, identified a…

fasciaextracellular matrixendothelium
A++2017

Biological effects of direct and indirect manipulation of the fascial system. Narrative review

Giovanni Parravicini, Andrea Bergna

This narrative review explores the biological effects of manual fascial therapies. While osteopathic manipulative treatment (OMT) is clinically effective, its underlying mechanisms are not fully understood. The authors…

fasciaMyofascial releaseManual Therapy
A+2017

Quantitative tissue parameters of Achilles tendon and plantar fascia in healthy subjects using a handheld myotonometer

Sarah Orner, Wolfgang Kratzer, Julian Schmidberger, Beate Grüner

This study examined the mechanical properties of the Achilles tendon and plantar fascia in over 150 healthy adults using a handheld device called a MyotonPRO. The goal was to establish baseline normal values for tissue…

fasciaachilles tendonplantar fascia
A2016

The tongue after whiplash: case report and osteopathic treatment

Bruno Bordoni, Fabiola Marelli, Bruno Morabito

This case report describes a 30-year-old man who experienced neck pain during swallowing and had a reduced ability to open his mouth following a whiplash injury. He was treated with osteopathic manual techniques directe…

fasciafascial releasetongue
A2016

Human Recombinant Hyaluronidase Injections For Upper Limb Muscle Stiffness in Individuals With Cerebral Injury: A Case Series

Preeti Raghavan, Ying Lu, Mona Mirchandani, Antonio Stecco

This case series investigated injections of the enzyme hyaluronidase to treat upper limb muscle stiffness in 20 individuals with cerebral injury. The researchers hypothesized that an accumulation of hyaluronan in the mu…

fasciaConnective tissueStroke
A2016

What Is Evidence-Based About Myofascial Chains: A Systematic Review

Jan Wilke, Frieder Krause, Lutz Vogt, Winfried Banzer

This systematic review evaluated anatomical dissection studies to find evidence for six proposed myofascial meridians. Researchers analyzed 62 studies and found strong evidence for the anatomical continuity of three lin…

fasciaForce transmissionmyofascial chains
A++2016

Ultra-weak photon emission in healthy subjects and patients with type 2 diabetes: evidence for a non-invasive diagnostic tool

Meina Yang, Wenyu Ding, Yanli Liu, Hua Fan, Rajendra P Bajpai, Jialei Fu, Jingxiang Pang, Xiaolei Zhao, Jinxiang Han

All living organisms emit extremely faint light, known as ultra-weak photon emission (UPE). This study investigated whether these light emissions differ between healthy individuals and people with type 2 diabetes. Resea…

fasciaphoton emissionbiological systems
C2016

Functional in vitro tension measurements of fascial tissue – a novel modified superfusion approach

Robert Schleip, Werner Klingler, S Wearing, I Naylor, M Zuegel, K Hoppe

In this laboratory study on rat tissue, researchers compared two techniques for measuring tension changes in fascia. The traditional method involves immersing the tissue in a fluid bath, but the team also tested a modif…

fasciaOrgan BathMechanographic Registration