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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 481–540 of 954 studies · page 9/16Since 2010With summary
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  1. A
    2018

    Pathobiology of cigarette smoke-induced invasive cancer of the renal pelvis and its prevention by vitamin C

    Shinjini Ganguly, Ayan Chandra, Indu B Chatterjee

    In this animal study, researchers investigated how cigarette smoke might cause invasive cancer of the renal pelvis and if vitamin C could offer protection. They found that when guinea pigs were exposed to cigarette smok…

    Invasive cancer of the renal pelvis Cigarette smoke Vitamin C Oxidative damage Persistent EGFR signaling Cell cycle deregulation
  2. A++
    2018

    Various stem cells in acupuncture meridians and points and their putative roles

    Jeanne Adiwinata Pawitan

    This narrative review explores the connection between acupuncture points and an anatomical network known as the Primo Vascular System (PVS). Formerly called the Bong-Han system, the PVS consists of microscopic vessels a…

    Bong-Han system; Kyungrak system; Primo microcell; Primo node; Primo vascular system; Primo vessel; Stem cell.
  3. A
    2018

    Biotensegrity and myofascial chains: A global approach to an integrated kinetic chain

    S L Dischiavi, A A Wright, E J Hegedus, C M Bleakley

    This theoretical paper proposes a holistic way to understand human movement, contrasting it with the traditional approach of studying body parts in isolation. The authors suggest a model based on "biotensegrity," where…

    RehabilitationbiotensegrityMuscular chainsDynamic knee valgusHip
  4. A
    2018

    Effectiveness of 3-dimensional shoulder ultrasound in the diagnosis of rotator cuff tears

    Aiping Teng, Fanxiao Liu, Dongsheng Zhou, Tao He, Yan Chevalier, Roland M Klar

    In this meta-analysis, researchers combined data from seven studies involving 282 patients to evaluate the effectiveness of 3-dimensional (3D) ultrasound in diagnosing rotator cuff tears. The analysis found that 3D ultr…

    3-dimensional ultrasounddiagnostic valuemeta-analysisrotator cuff tears
  5. B
    2017

    Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism

    Rosilene Cristina Rossetto Burgos, Johannes Cornelius Schoeman, Lennart Jan van Winden, Kateřina Červinková, Rawi Ramau…

    This laboratory study investigated a method for measuring oxidative stress, a process linked to many diseases. Researchers used a technique called ultra-weak photon emission (UPE) to monitor human cells in a dish after…

    Ultra-weak photon emission
  6. A+++
    2017

    Resveratrol supplementation reduces pain experience by postmenopausal women

    Rachel H X Wong, Hamish M Evans, Peter R C Howe

    This randomized, double-blind, placebo-controlled study investigated whether resveratrol supplementation could reduce pain and improve well-being in postmenopausal women. Over 14 weeks, participants taking 75 mg of resv…

    Resveratrolpolyphenolemenopause
  7. A+++
    2017

    Resveratrol Treatment Normalizes the Endothelial Function and Blood Pressure in Ovariectomized Rats

    Victor Fabricio, Jorge Camargo Oishi, Bruna Gabriele Biffe, Leandro Dias Gonçalves Ruffoni, Karina Ana da Silva, Keico…

    This animal study on rats investigated how resveratrol affects blood pressure and vascular function during estrogen deficiency, mimicking post-menopausal conditions. Researchers found that a lack of estrogen led to high…

    blood pressureresveratrolPostmenopause
  8. A+++
    2017

    Resveratrol regulates body weight in healthy and ovariectomized rats

    Rupali Sharma, Neel Kamal Sharma, M Thungapathra

    This animal study on rats investigated how the plant compound resveratrol affects body weight in both healthy subjects and those who had undergone ovariectomy, a model for menopause. The results suggest that resveratrol…

    OVX; Ovariectomy; Resveratrol; Soya free diet
  9. A+
    2017

    The Effect of Menstrual Cycle and Contraceptives on ACL Injuries and Laxity

    Simone D Herzberg, Makalapua L Motu’apuaka, William Lambert, Rongwei Fu, Jacqueline Brady, Jeanne-Marie Guise

    This systematic review and meta-analysis investigated the relationship between the menstrual cycle, hormonal contraceptives, and the risk of anterior cruciate ligament (ACL) injuries. The researchers found that knee lig…

    anterior cruciate ligament; knee injury; hormonal contraceptives; female; human; menstrual cycle; systematic review; meta-analysis; sports medicine
  10. 1A+
    2017

    Emotions in Motion: Myofascial Interoception

    B Bordoni, F Marelli

    In this perspective piece, the authors argue that the myofascial system is closely linked to our emotional state. They suggest that manual treatment not only affects the body physically but also activates the interocept…

    fasciaManual TherapyMyofascialOsteopathicInteroception
  11. A+++
    2017

    The deep fascia and retinacula of the equine forelimb - structure and innervation

    Aleksandra Skalec, Monika Egerbacher

    This study investigated the deep fascia and its reinforcements (retinacula) in the equine forelimb using anatomical dissection and microscopic analysis. The researchers found that horse fascia is structurally similar to…

    equine; fascia; forelimb; innervation; retinaculum; structure
  12. 1A++
    2017

    Microscopic anatomy of the visceral fasciae

    Carla Stecco, Maria Martina Sfriso, Andrea Porzionato, Anna Rambaldo, Giovanna Albertin, Veronica Macchi, Raffaele De C…

    Researchers examined the microscopic structure of visceral fascia—the connective tissue surrounding internal organs—from eight cadavers. They analyzed samples from the thorax, abdomen, and around organs like the heart,…

    elastic lamina; Gerota fascia; pericardium; peritoneum; serous membrane; visceral fascia; visceral manipulation.
  13. A+++
    2017

    Proinflammatory Cytokines and Oxidative Stress Decrease the Transport of Dopamine Precursor Tyrosine in Human Fibroblasts

    Ravi Vumma, Jessica Johansson, Nikolaos Venizelos

    This laboratory study investigated how inflammation and oxidative stress affect the transport of the amino acid tyrosine in human fibroblasts, a type of connective tissue cell. Tyrosine is a crucial precursor for the ne…

    Dopamine precursor; Human fibroblasts; Neuropsychiatric disorders; Oxidative stress; Proinflammatory cytokines; Tyrosine transport.
  14. A+++
    2017

    Electric Nutrition: The Surprising Health and Healing Benefits of Biological Grounding (Earthing)

    Stephen T Sinatra, James L Oschman, Gaétan Chevalier, Drew Sinatra

    This narrative review summarizes research on grounding (earthing), which involves direct physical contact with the Earth's surface. The authors suggest that grounding may provide a form of "electric nutrition" with pote…

    Grounding
  15. B
    2017

    Sensitivity of ACL Volume and T2* Relaxation Time to Magnetic Resonance Imaging Scan Conditions

    Jillian E Beveridge, Edward G Walsh, Martha M Murray, C Fleming

    This animal study investigated how different magnetic resonance imaging (MRI) conditions affect measurements of the anterior cruciate ligament (ACL). Researchers in this pig study compared images taken at different reso…

    ACL; MRI; T2* relaxometry
  16. A++
    2017

    Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis

    Gregory Shaw, Ann Lee-Barthel, Megan L R Ross, Bing Wang, Keith Baar

    In a small study involving eight healthy men, researchers investigated the effect of vitamin C-enriched gelatin supplementation before exercise. Participants who consumed 15 grams of gelatin one hour before a short, int…

    Bonetendonexerciseligamentreturn to play
  17. C
    2017

    S100A4 in cancer progression and metastasis: A systematic review

    Fei Fei, Jie Qu, Mingqing Zhang, Yuwei Li, Shiwu Zhang

    This systematic review examines the role of the protein S100A4 in cancer progression and metastasis. S100A4 is involved in the epithelial-mesenchymal transition, a key process that allows cancer cells to spread. The aut…

    metastasisS100A4malignant tumorepithelial-mesenchymal transition
  18. A
    2017

    Acute effects of foam rolling on passive tissue stiffness and fascial sliding: study protocol for a randomized controlled trial

    Frieder Krause, Jan Wilke, Daniel Niederer, Lutz Vogt, Winfried Banzer

    This document is a study protocol, outlining the planned method for a randomized controlled trial, not a report of its results. The researchers intend to investigate the immediate effects of foam rolling on the anterior…

    Connective tissue; Cross-correlation; Fascia; Flexibility; Foam rolling; Self-myofascial release; Tissue stiffness; Ultrasound.
  19. B
    2017

    Acoustic wave therapy for cellulite, body shaping and fat reduction

    Doris Hexsel, Fernanda Oliveira Camozzato, Aline Flor Silva, Carolina Siega

    This study evaluated the efficacy of acoustic wave therapy (AWT) for cellulite and body shaping. Thirty women with moderate to severe cellulite underwent 12 treatment sessions on the glutes and thighs over six weeks. Th…

    Acoustic wave therapy; body shaping; cellulite; Cellulite Severity Scale; subcutaneous fat tissue thickness
  20. A++
    2017

    A New Definition of an Acupuncture Meridian

    Fletcher Kovich

    This perspective article proposes a new definition of acupuncture meridians, moving away from the idea of dedicated anatomical vessels. The author suggests that meridians are actually tracts of tissue that become affect…

    acupunctureelectrical wavesemiconductionsignal propagation
  21. A
    2017

    Non-contrast MRI diagnosis of adhesive capsulitis of the shoulder

    Andrew S Chi, John Kim, Suzanne S Long, William B Morrison, Adam C Zoga

    This study investigated whether a standard MRI without contrast dye could be used to reliably diagnose adhesive capsulitis, also known as frozen shoulder. Researchers reviewed MRIs for specific signs, such as a thickene…

    MRIfrozen shoulderAdhesive capsulitisNoncontrast
  22. A
    2017

    Correlations of magnetic resonance imaging findings with clinical symptom severity and prognosis of frozen shoulder

    Jong Pil Yoon, Seok Won Chung, Byung Joo Lee, Hyung Sup Kim, Jae Hyuck Yi, Hyun‑Joo Lee, Won‑Ju Jeong, Sung Gyu Moon, K…

    Researchers used a specific type of MRI (indirect MR arthrography) to examine the shoulders of 52 people with frozen shoulder and 52 without. They found that certain features, like thickening and inflammation-related ch…

    frozen shoulderMR findingIndirect MR arthrogramClinical symptomCorrelation
  23. A
    2017

    Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles

    Uma Thanigai Arasu, Riikka Kärnä, Kai Härkönen, Sanna Oikari, Arto Koistinen, Heikki Kröger, Chengjuan Qu, Mikko J Lamm…

    Mesenchymal stem cells (MSCs) are known to help with tissue repair, partly by releasing tiny packages called extracellular vesicles (EVs). This study investigated the connection between these EVs and hyaluronan (HA), a…

    Hyaluronan; CD44; Extracellular vesicle; Stem cell; Filopodia; Hyaluronan synthase
  24. A++
    2017

    A Curious Oversight in Acupuncture Research

    Fletcher Kovich

    In this perspective article, the author argues that current acupuncture hypotheses overlook a crucial factor: the speed at which the treatment takes effect. Observations suggest that communication between acupoints and…

    acupunctureelectrical wavesemiconductionsignal propagation
  25. B
    2017

    Evaluation of fascial manipulation in carpal tunnel syndrome

    Marco Pintucci, Marta Imamura, Aurore Thibaut, Lucas M de Exel Nunes, Mylene Mayumi Nagato, Helena H Kaziyama, Satiko T…

    Details for this study are not yet available. The research, published in 2017, appears to evaluate the effectiveness of Fascial Manipulation® for treating carpal tunnel syndrome. Without an abstract, further details abo…

    Fascial manipulationcarpal tunnel syndrome
  26. A
    2017

    Don’t Forget the Abdominal Wall: Imaging Spectrum of Abdominal Wall Injuries after Nonpenetrating Trauma

    Shanna A Matalon, Reza Askari, Jonathan D Gates, Ketan Patel, Aaron D Sodickson, Bharti Khurana

    Abdominal wall injuries from non-penetrating trauma are relatively common but are often overlooked in the emergency department. This can happen because more severe, distracting injuries draw attention away, or because t…

    abdominal wallabdominal wall injuriesabdominal wall herniaabdominal wall muscle injurycostochondral rib injury
  27. A+
    2017

    Quantitative tissue parameters of Achilles tendon and plantar fascia in healthy subjects using a handheld myotonometer

    Sarah Orner, Wolfgang Kratzer, Julian Schmidberger, Beate Grüner

    This study examined the mechanical properties of the Achilles tendon and plantar fascia in over 150 healthy adults using a handheld device called a MyotonPRO. The goal was to establish baseline normal values for tissue…

    fasciaachilles tendonplantar fasciaMyotonePRO
  28. A
    2017

    Adhesive Capsulitis of the Shoulder Joint: Value of Glenohumeral Distance on Magnetic Resonance Arthrography

    Kyu Hong Lee, Hee Jin Park, So Yeon Lee, In Young Youn, Eugene Kim, Jai Hyung Park, Se Jin Park

    Researchers investigated a new way to help diagnose adhesive capsulitis (frozen shoulder) using a specific type of MRI called MR arthrography. They measured the distance between the ball and socket of the shoulder joint…

    Adhesive capsulitisMR imagingShoulderArthrography
  29. A++
    2017

    Massage therapy research review

    Tiffany Field

    This review summarizes research showing beneficial effects of massage therapy for a wide range of conditions, including prenatal depression, pain syndromes, autoimmune conditions, and issues related to aging. The author…

    Massage therapy research review
  30. A+++
    2017

    Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase

    Hai-Tao Zhang, Zi-Jian Zhang, Wei-Chuan Mo, Ping-Dong Hu, Hai-Min Ding, Ying Liu, Qian Hua, Rong-Qiao He

    This study investigates how an extremely weak magnetic field, similar to conditions in outer space or shielded environments on Earth, affects human cells. Researchers found that shielding the natural geomagnetic field r…

    hydrogen peroxide; hypomagnetic field; oxidative stress; reactive oxygen species; superoxide dismutase
  31. A++
    2017

    Interaction between the gut microbiome and mucosal immune system

    Na Shi, Na Li, Xinwang Duan, Haitao Niu

    In this narrative review, the authors outline the two-way relationship between the gut microbiome and the mucosal immune system. A balanced microbiome is essential for the proper maturation and function of the immune sy…

    inflammationMicrobiomeImmunity
  32. A
    2017

    Effect of MELT method on thoracolumbar connective tissue: The full study

    Faria Sanjana, Hans Chaudhry, Thomas Findley

    This study investigated if the MELT method, a self-treatment technique using soft rollers and balls, could affect the thoracolumbar connective tissue in people with chronic low back pain. Researchers used ultrasound ima…

    Low back pain; MELT method; Connective tissue; Thickness; Myofascia; Flexibility
  33. A
    2017

    Amino acid composition in determination of collagen origin and assessment of physical factors effects

    Marlena Gauza-Włodarczyk, Leszek Kubisz, Dariusz Włodarczyk

    This study examines the amino acid composition of collagen derived from various sources, including fish skin, bovine Achilles tendon, and bone tissue. The researchers found that the levels of hydroxyproline, a unique am…

    hydroxyprolineBone collagenFish skin collagenIrradiationPolymer
  34. C
    2017

    Hypermobile Ehlers–Danlos Syndrome (a.k.a. Ehlers–Danlos Syndrome Type III and Ehlers–Danlos Syndrome Hypermobility Type): Clinical Description and Natural History

    Brad Tinkle, Marco Castori, Britta Berglund, Helen Cohen, Rodney Grahame, Hanadi Kazkaz, Howard Levy

    This 2017 review summarizes the clinical understanding of hypermobile Ehlers-Danlos syndrome (hEDS), thought to be the most common hereditary disorder of connective tissue. It is primarily characterized by musculoskelet…

    joint hypermobilityjoint hypermobility syndromeEhlers–Danlos syndrome type IIEhlers–Danlos syndrome hypermobility type
  35. A++
    2017

    Biological effects of direct and indirect manipulation of the fascial system. Narrative review

    Giovanni Parravicini, Andrea Bergna

    This narrative review explores the biological effects of manual fascial therapies. While osteopathic manipulative treatment (OMT) is clinically effective, its underlying mechanisms are not fully understood. The authors…

    fasciaMyofascial releaseManual TherapyMyofascial manipulation
  36. A++
    2017

    The effect of pre-exercise vibration stimulation on the exercise-induced muscle damage

    Ji-Yun Kim, Da-Haeng Kang, Joon-Hee Lee, Se-Min O, Jae-Keun Jeon

    This study investigated whether vibration stimulation before or after exercise could reduce exercise-induced muscle damage. Thirty healthy men were divided into three groups: one receiving vibration before exercise, one…

    pressure pain thresholdmuscle fatiguemuscle damage
  37. A
    2017

    Reconnecting the Body in Eastern and Western Medicine

    Helene M Langevin, Rosa N Schnyer

    Details for this 2017 publication, titled 'Reconnecting the Body in Eastern and Western Medicine' by Helene M. Langevin and Rosa N. Schnyer, have not yet been summarized. The title suggests a discussion comparing and in…

    acupunctureTCM
  38. A++
    2017

    Telocytes: Connective tissue repair and communication cells

    Leon Chaitow

    This commentary highlights a newly identified type of connective tissue cell called a telocyte. We already know that other cells, like fibroblasts, respond to mechanical forces from manual therapy, influencing tissue re…

    mechanotransductiontelocytesinterstitial cellsregeneration
  39. A++
    2017

    EFFECT OF MATRIX RHYTHM THERAPY (MRT) COMBINED WITH PHYSIOTHERAPY INTERVENTION IN FROZEN SHOULDER – A CASE REPORT

    Vijay Bhartiya, Shrikant Darade, Sandip Bhagwat, Manjumala Roy

    This case report describes the treatment of a 52-year-old man with a painful and stiff right shoulder, diagnosed as frozen shoulder. His condition also involved tendinosis, bursitis, and osteoarthritic changes. The pati…

    exercisesfrozen shoulderMRT
  40. A
    2017

    Telocytes heterogeneity: From cellular morphology to functional evidence

    Dragos Cretoiu, Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Sanda Maria Cretoiu

    This review discusses telocytes, a recently identified type of cell found throughout the connective tissue (stroma) of vertebrates. They are characterized by extremely long, thin extensions called telopodes, which form…

    cancertelocytesregenerative medicinestem cellsImmunophenotype heterogeneity
  41. A
    2017

    Muscle strength and stiffness in resistance exercise: Force transmission in tissues

    Hans Chaudhry, Bruce Bukiet, Ellen Z Anderson, Jared Burch, Thomas Findley

    Researchers used a mathematical model to estimate how forces are transmitted through the quadriceps muscle during isometric resistance exercises. They specifically looked at how knee angle affects muscle stiffness, stre…

    Knee muscle strength; Stiffness; Mathematical modeling; Resistance exercise
  42. A
    2017

    What's in a name: Myofascial Release or Myofascial Induction?

    Leon Chaitow

    This commentary discusses two terms for a similar manual therapy technique: Myofascial Release (MFR) and Myofascial Induction Therapy (MIT). The author notes that while the techniques are virtually identical, the names…

    Myofascial releaseMyofascial Induction therapy
  43. B
    2017

    All you need to know about the AIP diet

    Lana Burgess

    This article reviews the Autoimmune Protocol (AIP) diet, which aims to reduce inflammation and relieve symptoms of autoimmune disorders. The diet is based on the idea that problems with the gut wall, sometimes called 'l…

    inflammationAutoimmune protocolautoimmune disease
  44. A+
    2017

    Oxidative Stress and Endometriosis: A Systematic Review of the Literature

    Gennaro Scutiero, Piergiorgio Iannone, Giulia Bernardi, Gloria Bonaccorsi, Savino Spadaro, Carlo Alberto Volta, Pantale…

    This systematic review explores the connection between oxidative stress and endometriosis, a condition where uterine-like tissue grows outside the uterus, causing pain and infertility. Oxidative stress is an imbalance b…

    Oxidative stressendometriosisROS
  45. A
    2017

    Implications of immune dysfunction on endometriosis associated infertility

    Jessica E Miller, Soo Hyun Ahn, Stephany P Monsanto, Kasra Khalaj, Madhuri Koti, Chandrakant Tayade

    This literature review explores the link between endometriosis and infertility, a common issue for which the cause is not fully understood. The authors suggest that dysfunction in the immune system plays a significant r…

    cytokines; endometriosis; infertility; inflammation; oxidative stress.
  46. A++
    2017

    Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate

    Shilpy Dixit, Joshua P Fessel, Fiona E Harrison

    In this animal study, researchers examined mitochondrial function in a mouse model of Alzheimer's disease and in mice with low levels of vitamin C (ascorbate). The results indicated that both the presence of amyloid (as…

    Alzheimer’s disease; mitochondria; oxidative stress; ascorbate; energy production
  47. A
    2017

    The second terminations of the suboccipital muscles: An assistant pivot for the To Be Named Ligament

    Xiao-Ying Yuan, Chan Li, Jia-Ying Sui, Qi-Qi Zhao, Xiao Zhang, Na-Na Mou, Zhao Huang-Fu, Okoye Chukwuemeka Samuel, Nan…

    In this anatomical dissection study of 35 head-neck specimens, researchers investigated small muscle attachments in the suboccipital region. The scientists confirmed the existence of "second terminations" from several s…

    Myodural Bridge
  48. A++
    2017

    Vitamin C and Immune Function

    Anitra C Carr, Silvia Maggini

    This narrative review explores the crucial role of Vitamin C in the human immune system. As a potent antioxidant, it supports various functions in both the innate and adaptive immune responses, from strengthening the sk…

    ascorbate; ascorbic acid; immunity; immune system; neutrophil function; microbial killing; lymphocytes; infection; vitamin C
  49. A
    2017

    Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis

    Harri Hemilä, Timo Suonsyrjä

    This systematic review and meta-analysis examined 15 trials to see if vitamin C could prevent atrial fibrillation in high-risk patients. The analysis, involving over 2000 subjects, found inconsistent results depending o…

    Ascorbic acidantioxidantArrhythmiaAtrial fibrillationCardiac surgery
  50. A++
    2017

    Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes

    Anitra C Carr, Patrice C Rosengrave, Simone Bayer, Steve Chambers, Jan Mehrtens, Geoff M Shaw

    This study investigated vitamin C levels in 44 critically ill patients in an intensive care unit (ICU). Researchers found that most patients had low vitamin C levels (hypovitaminosis C), and one-third were severely defi…

    Vitamin CsepsisIntensive careHypovitaminosis CCritical illness
  51. A
    2017

    The universal existence of myodural bridge in mammals: an indication of a necessary function

    Nan Zheng, Xiao-Ying Yuan, Yan-Yan Chi, Pei Liu, Bing Wang, Jia-Ying Sui, Seung-Ho Han, Sheng-Bo Yu, Hong-Jin Sui

    The myodural bridge is a connective tissue structure linking one of the deep, upper neck muscles to the spinal dura mater. This anatomical study investigated whether this structure, known in humans, also exists in other…

    Myodural Bridge
  52. A+
    2017

    Theoretical study of aerobic vitamin C loss kinetics during commercial heat preservation and storage

    Micha Peleg

    This theoretical study presents a mathematical model to describe how vitamin C is lost in food during commercial heat processing and storage. The model accounts for the degradation of two forms of the vitamin, ascorbic…

    Ascorbic acid; Degradation reactions; Dehydroascorbic acid; Kinetics; Storage; Thermal processing.
  53. B
    2017

    Mechanical Properties of the Cytoskeleton and Cells

    A F Pegoraro, P Janmey, D A Weitz

    In this review article, the authors describe the cytoskeleton, which is the cell's main mechanical structure. It is a complex and dynamic network of biopolymers that includes microtubules, actin, and intermediate filame…

    cytoskeletonmicrotubulesactin filamentintermediate filament
  54. A++
    2017

    Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study

    Paul E Marik, Vikramjit Khangoora, Racquel Rivera, Michael H Hooper, John Catravas

    In this retrospective before-after study, researchers investigated the effect of a combination therapy of intravenous vitamin C, hydrocortisone, and thiamine for patients with severe sepsis and septic shock. They compar…

    corticosteroid; hydrocortisone; septic shock; thiamine; vitamin C
  55. B
    2017

    Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

    Hsin-Ying Huang, Ana Rivas-Caicedo, François Renevey, Hélène Cannelle, Elisa Peranzoni, Leonardo Scarpellino, Debbie L…

    This study investigated how antibody-producing plasma cells are supported within lymph nodes. Researchers identified a specific type of connective tissue cell, a medullary fibroblastic reticular cell (FRC), that forms a…

    FRC subsetslymph node medullaextrafollicular B cell differentiationplasma cell survivalhumoral response
  56. A+++
    2017

    Role of Magnesium in Vitamin D Activation and Function

    Anne Marie Uwitonze, Mohammed S Razzaque

    In this scientific review, the authors discuss how magnesium and vitamin D work together in the body. Magnesium acts as a cofactor, meaning it helps activate the enzymes that metabolize vitamin D in the liver and kidney…

    Vitamin D activationmagnesiumcalcidefiolcalcitriol
  57. C
    2017

    Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface

    KA Khan, AJ Naylor, A Khan, PJ Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, CD Buckley, BE Willcox, F Mohammed ,…

    Researchers investigated how certain proteins interact to form new blood vessels, a process called angiogenesis that is crucial for tumor growth. This study, which included lab experiments and mouse models, identified a…

    fasciaextracellular matrixendotheliumC-type lectintumor angiogenesis
  58. A+++
    2017

    Therapeutic effectiveness of instrument-assisted soft tissue mobilization for soft tissue injury: mechanisms and practical application

    Jooyoung Kim, Dong Jun Sung, Joohyung Lee

    This narrative review explores the mechanisms and practical use of Instrument-Assisted Soft Tissue Mobilization (IASTM) for treating soft tissue injuries. IASTM involves using specialized tools to apply mechanical press…

    Injury; Instrument-assisted soft tissue mobilization; Pain; Range of motion; Soft tissue function.
  59. A
    2017

    Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale

    Charles Reilly, Donald E Ingber

    A project that began as an artistic endeavor to create an entertaining short film about fertilization led to the development of a new scientific simulation tool. By integrating physics-based animation software from the…

    Tensegritysimulationanimationaxonemedynein
  60. A+
    2017

    Hyaluronan as a therapeutic target in human diseases

    Jiurong Liang, Dianhua Jiang, Paul W Noble

    This narrative review explores the role of hyaluronan, a major component of the extracellular matrix involved in tissue injury and repair. Its function varies significantly with its size; fragmented hyaluronan can promo…

    hyaluronan