Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A2020
The link between vitamin D and COVID-19: distinguishing facts from fiction
P BergmanThis 2020 article, available only by title, appears to be a review or commentary on the relationship between vitamin D and COVID-19. The title, "The link between vitamin D and COVID-19: distinguishing facts from fiction…
COVID-19vitamin D - A2020
Evaluation of scapular mobilization and comparison to pectoralis minor stretching in individuals with rounded shoulder posture: A randomized controlled trial
Maedeh Fani, Samaneh Ebrahimi, Ali GhanbariThis randomized controlled trial investigated treatments for rounded shoulder posture in 52 healthy students. Researchers compared the effects of scapular mobilization, pectoralis minor self-stretching, and a combinatio…
Mobilization; Pectoralis minor stretching; Rounded shoulder; Scapular kinematics. - A++2020
Extracellular Vesicles Released From Articular Chondrocytes Play a Major Role in Cell-Cell Communication
Xiaoming Liu, Claire Shortt, Fenglin Zhang, Mariah Q Bater, Mary K Cowman, Thorsten KirschThis narrative review examines the role of extracellular vesicles (EVs) as crucial mediators in cell-to-cell communication. EVs are small, lipid-enclosed particles that transport proteins, lipids, and genetic material t…
articular chondrocytes; catabolic events; chondrogenesis; extracellular vesicles - A2020
Muscle Cramps
Bruno Bordoni, Kavin Sugumar, Matthew VaracalloMuscle cramps are involuntary, painful, and localized contractions of a muscle or muscle fibers, often felt as a palpable knot. While common in sports, their exact cause is not fully understood and likely depends on var…
Diagnosiscramp - A+++2020
Fasting-mimicking diet plus chemotherapy in breast cancer treatment
Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini, Filippo de BraudThis clinical trial investigated whether a fasting-mimicking diet (FMD) combined with chemotherapy could improve outcomes for breast cancer patients. The overall results were negative, meaning the study did not find a s…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; breast cancer - A2020
Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis
Eric Gracey, Arne Burssens, Isabelle Cambré, Georg Schett, Rik Lories, Iain B. McInnes, Hiroshi Asahara, Dirk ElewautThis review article discusses how mechanical loading affects tendons and ligaments. While normal levels of loading are essential for maintaining tissue health, pathological levels of force act as a stressor that can tri…
mechanical stressMechanical loadingtendonrepair of tissueligament - 1A+2019
Fascia Is Able to Actively Contract and May Thereby Influence Musculoskeletal Dynamics: A Histochemical and Mechanographic Investigation
Robert Schleip, G Gabbiani, Jan Wilke, I Naylor, B Hinz, A Zorn, Heike Jäger, R Breul, S Schreiner, Werner KlinglerThis study investigated whether fascia can actively contract, challenging the traditional view of it as a passive tissue. Researchers examined human and rat fascial samples for the presence of contractile cells called m…
Connective tissuestiffnessmyofibroblastscontractilitycontracture - A2019
Mechanobiology of cells and cell systems, such as organoids
Ece Bayir, Aylin Sendemir, Yannis F MissirlisThis review discusses organoids, which are three-dimensional tissues grown in a lab that self-organize to mimic organ development. While organoids offer great potential for disease modeling and drug development, little…
mechanotransductionmechanobiologyOrganoidMechanoepigeneticsCollective cell behavior - A2019
Imaging of ultraweak photon emission for evaluating the oxidative stress of human skin
Katsuhiko Tsuchidaa, Torai Iwasab, Masaki KobayashiThis study explored a method for visualizing oxidative stress in human skin by imaging ultraweak photon emission (UPE), also known as biophotons. Researchers found that exposing skin to UV radiation increased the intens…
BiophotonOxidationImagingNon-invasiveUltraviolet - A+++2019
Vitamin C and Neutrophil Function: Findings from Randomized Controlled Trials
Mikee Liugan, Anitra C CarrThis systematic review examined how vitamin C supplementation affects neutrophils, a key type of immune cell. Researchers analyzed 16 randomized controlled trials that measured neutrophil functions like their ability to…
vitamin C; ascorbic acid; neutrophils; polymorphonuclear leukocytes; migration; chemotaxis; apoptosis; phagocytosis; oxidative burst; systematic review - A2019
Association of thoraco-lumbar fascia length in individuals with non-specific low back pain - an observational study
Shellette D' Almeida, Charu Eapen, Shyam KrishnanThis observational study compared 31 people with non-specific low back pain to 31 healthy individuals to investigate the thoracolumbar fascia (TLF). Researchers measured TLF length by assessing lumbar spine rotation, an…
low back painthoracolumar fascia lenght - C2019
Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain
Chu-Ting Chang, Sitt Wai Fong, [...], Chih-Cheng ChenIn this animal study, researchers investigated the role of a specific ion channel, called ASIC1b, in the development of chronic muscle pain. They created a fibromyalgia-like condition by injecting acid into the leg musc…
FibromyalgiapainASICASIC1bASIC3 - A2019
Lymphatic pump manipulation in patients with chronic obstructive pulmonary disease
Bruno BordoniThis narrative review examines the use of lymphatic pump manipulation for patients with chronic obstructive pulmonary disease (COPD). COPD is characterized by persistent inflammation, and lymphatic techniques aim to red…
inflammationfasciaOsteopathicCOPDlymphatic pump - A2019
Cranial osteopathy: Obscurantism and Enlightenment
Bruno Bordoni, Bruno Morabito, Marta SimonelliIn this reflective article, the authors discuss the controversial aspects of cranial osteopathy. They address common objections, such as the idea that the cranial bones are immobile in adults and that an operator's hand…
fasciaOsteopathicquantum physicsneurophysiologycranio - A2019
Benefits of adding stretching to a moderate-intensity aerobic exercise programme in women with fibromyalgia: a randomized controlled trial
Miguel Gómez-Hernández, Tomás Gallego-Izquierdo, Patricia Martínez-Merinero, Daniel Pecos-Martín, Alejandro Ferragut-Ga…This randomized controlled trial investigated whether adding stretching to a moderate-intensity aerobic exercise program provided extra benefits for women with fibromyalgia. One group performed moderate aerobic exercise…
FibromyalgiaStretchingpainsleep qualityquality of life - A2019
Biophysics of Cell-Substrate Interactions Under Shear
Neha Paddillaya, Ashish Mishra, Paturu Kondaiah, Pramod Pullarkat, Gautam I Menon, Namrata GundiahIn this review article, the authors examine how cells adhere to surfaces and respond to mechanical forces. Cells use complex structures called focal adhesions to sense and react to their environment, including forces fr…
mechanotransductionfocal adhesionsstress fibersshear stress and devicesbiophysical models - A++2019
A History of Fascia
Sue Adstrum, H NicholsonThis historiographic review surveys how the anatomical term "fascia" has been portrayed throughout history. The authors found that its meaning has varied considerably during the 400 years the term has been used in Engli…
anatomical terminology; fascia; fascial system; integrative anatomy; medical history - A2019
The plasma membrane as a mechanochemical transducer
Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-CusachsIn this review article, researchers describe how the plasma membrane, the cell's outer boundary, acts as a key sensor for mechanical forces. The membrane senses and responds to physical stresses from its environment, su…
mechanotransductionmechanosensorplasma membranemembrane tension - B2019
Stiffness and echogenicity: Development of a stiffness-echogenicity matrix for clinical problem solving
Antonio Stecco, Carmelo Pirri, Raffaele De Caro, Preeti RaghavanAssessing soft tissue stiffness is important for many neuromusculoskeletal conditions, but can be challenging. While ultrasound can measure a tissue's echogenicity (how it reflects sound waves), this is not directly pro…
stiffnessultrasound.Elastographyechogenicity - A2019
Anterior capsular abnormality: another important MRI finding for the diagnosis of adhesive capsulitis of the shoulder
Jina Park, Yoon-Hee Choi, Jee Won Chai, Seung Woo Cha, Joo Hee Lim, Chris Hyunchul Jo, Dong Hyun KimThis retrospective study investigated whether abnormalities in the shoulder's anterior joint capsule, seen on MRI scans, can help diagnose adhesive capsulitis (frozen shoulder). Researchers compared MRIs from 29 patient…
Anterior capsular abnormalityAdhesive capsulitis of shoulderAnterior capsular thicknessAnterior capsular abnormal hyperintensity - A+++2019
Vitamin C: an essential “stress hormone” during sepsis
Paul E MarikThe body's stress response involves hormones like cortisol and catecholamines, but in most mammals, it also includes increased production of vitamin C. These substances work together to protect the body from damage duri…
Sepsis; vitamin C; HPA axis; stress response - A2019
Adhesive capsulitis: MRI correlation with clinical stages and proposal of MRI staging
Amarnath Chellathurai, Komalavalli Subbiah, Atchaya Elangovan,, Sivakumar KannappanThis study investigated whether magnetic resonance imaging (MRI) findings can reflect the clinical stages of adhesive capsulitis, also known as frozen shoulder. Researchers analyzed MRIs from 74 patients, looking for sp…
Adhesive capsulitis; MRI staging; magnetic resonance imaging; frozen shoulder - A2019
Role of matrix metalloproteinases 2 and 9 in the development of frozen shoulder: human data and experimental analysis in a rat contracture model
Chul-Hyun Cho, Yun-Mee Lho, Ilseon Hwang, Du Hwan KimThis study investigated the biological processes behind frozen shoulder, a condition characterized by pain and stiffness. Researchers analyzed joint capsule tissue from both patients with frozen shoulder and from a rat…
inflammationfibrosisfrozen shoulderimmobilizationrat; matrix metalloproteinases - A2019
Adhesive capsulitis: review of imaging findings, pathophysiology, clinical presentation, and treatment options
Brandon K K Fields, Matthew R Skalski, Dakshesh B Patel, Eric A White, Anderanik Tomasian, Jordan S Gross, George R Mat…This narrative review summarizes the current understanding of adhesive capsulitis, commonly known as "frozen shoulder." This debilitating condition, characterized by progressive pain and stiffness in the shoulder joint,…
frozen shoulderAdhesive capsulitiscoracohumeral ligamentMagnetic resonance imagingSubcoracoid fat triangle - A2019
3D volumetric MR arthrographic assessment of shoulder joint capacity in patients with primary adhesive capsulitis
Hayri Ogul, Nurmuhammet Tas, Kutsi Tuncer, Gokhan Polat, Yasemin Ogul, Berhan Pirimoglu, Mecit KantarciThis study used 3D MR arthrography to measure and compare shoulder joint volume in patients with primary adhesive capsulitis (frozen shoulder) against a healthy control group. Researchers found that the patient group ha…
frozen shoulderAdhesive capsulitisMR arthrography - A2019
Dermatome and Fasciatome
Carla Stecco, Carmelo Pirri, Caterina Fede, Chenglei Fan, Federico Giordani, Luigi Stecco, Calogero Foti, Raffaele De C…This theoretical paper proposes a new distinction between the body's sensory maps, based on increased knowledge of fascial innervation. The authors define a "dermatome" as the area of skin and superficial fascia supplie…
fascia; dermatome; nerve; pain; proprioception - B2019
Extracellular matrix composition of connective tissues: a systematic review and meta-analysis
Turney J McKee, George Perlman, Martin Morris, Svetlana V KomarovaThis systematic review and meta-analysis compiled data to quantify the protein composition of the extracellular matrix (ECM) in various human connective tissues. Researchers analyzed data from studies on bone, adipose t…
extracellular matrixmatrix remodelingcollagen content - 1A+2019
Role of fasciae in nonspecific low back pain
G Casato, Carla Stecco, R BusinResearch increasingly links the thoracolumbar fascia to non-specific low back pain. This small case study explored the idea that pain could originate elsewhere in the body's continuous fascial network. Five patients wit…
fascianonspecific low back painlimb myofascial manipulationfascial continuitycase series - A++2019
Observation using thermography of post-operative reaction after fascial manipulation®
Joanna Fidut-Wrońska, Kamil Chołuj, Justyna Chmiel, Katarzyna Pikto-Pitkiewicz, Piotr MajcherThis study investigated whether Fascial Manipulation® causes a local increase in skin temperature, which is theorized to be part of its mechanism. Researchers used a thermal-imaging camera to measure skin temperature in…
inflammationFascial manipulationthermography - A2019
Hierarchical Hydrogel Composite Interfaces with Robust Mechanical Properties for Biomedical Applications
Yuting Zhu, Qiang Zhang, Xiaoli Shi, Dong HanThis review summarizes advances in hydrogel composites, materials designed to mimic the body's extracellular matrix (ECM). Cells naturally sense and respond to the mechanical properties and physical structure of the ECM…
tissue engineeringECMHydrogels - A+2019
Ultrasound-detected connective tissue involvement in acute muscle injuries in elite athletes and return to play: The French National Institute of Sports (INSEP) study
Jérôme Renoux, Jean-Louis Brasseur, Mathilde Wagner, Alain Frey, Dominique Folinais, Christian Dibie, Djamila Maiza, Mi…This study examined 70 elite athletes with acute muscle injuries. Researchers used ultrasound within seven days to assess injury severity and to see if connective tissue was involved. They then tracked the time it took…
ultrasound.return to playMuscle injuriesConnective tissue injury - A++2019
A prophylactic effect of local vibration on quadriceps muscle fatigue in non-athletic males: a randomized controlled trial study
Khadijeh Otadi, Mehri Ghasemi, Shohreh Jalaie, Hossein Bagheri, Morteza Azizian, Saeid Emamdoost, Hadi Sarafraz, Mustap…This randomized controlled trial investigated whether local vibration could prevent muscle fatigue. Thirty healthy, non-athletic young men were divided into two groups: one received two minutes of vibration on their qua…
Musclefatiguevibration - A++2019
Mitochondrial superoxide anions induced by exogenous oxidative stress determine tumor cell fate: an individual cell-based study
Hui PAN, Bao-hui WANG, Zhou-bin LI, Xing-guo GONG, Yong QIN, Yan JIANG, Wei-li HANIn this cell-based study, researchers investigated how external oxidative stress affects individual lung cancer cells. They found that applying a stressor like hydrogen peroxide caused a rapid increase in reactive oxyge…
Individual cell; Superoxide anion; Reactive oxygen species (ROS) dynamics; Intrinsic apoptotic pathway; Ca2+ signaling - A2019
Evaluation of the Structure of Myodural Bridges in an Equine Model of Ehlers-Danlos Syndromes
Abigail McElroy, Ann Rashmir, Jane Manfredi, Dodd Sledge, Elizabeth Carr, Edward Stopa, Petra KlingeThis animal study investigated myodural bridges—connective tissue links between small neck muscles and the spinal cord's outer covering (dura mater)—in horses. Researchers compared horses with a genetic connective tissu…
Myodural BridgeEhlers-danlos syndromes - A2019
The myodural bridge complex defined as a new functional structure
Nan Zheng, Beom Sun Chung, Yi-Lin Li, Tai-Yuan Liu, Lan-Xin Zhang, Yang-Yang Ge, Nan-Xing Wang, Zhi-Hong Zhang, Lin Cai…The myodural bridge is a known connective tissue link between the deep suboccipital muscles and the spinal cord's outermost covering, the dura mater. In this anatomical study, researchers examined its precise structure…
Myodural BridgeThree-dimensional visualization modelP45 plastinated slicesSuboccipital region - A2019
Suboccipital Myodural Bridges Revisited: Application to Cervicogenic Headaches
KEI KITAMURA, KWANG HO CHO, MASAHITO YAMAMOTO, MICHITAKE ISHII, GEN MURAKAMI, JOSÉ FRANCISCO RODRÍGUEZ-VÁZQUEZ, SHIN-IC…This anatomical study investigated the connective tissue structures, known as myodural bridges, in the suboccipital region of 30 human fetuses. Researchers identified two types of these bridges connecting muscles at the…
fetuses; atlas; cervical; cervical vertebra axis; pachymeninx; elastic fibers; cervicogenic headaches - A2019
Existence and features of the myodural bridge in Gallus domesticus: indication of its important physiological function
Ya-Ru Dou, Nan Zheng, Jing Gong, Wei Tang, Chukwuemeka Samuel Okoye, Ying Zhang, Yu-Xiao Chen, Yu Zhang, Shi-Yi Pi, Lia…In this anatomical animal study, researchers investigated the existence of the myodural bridge (MDB) in chickens. The MDB is a dense connective tissue that links muscles in the upper neck to the spinal dura mater. The i…
Myodural Bridgecerebrospinal fluid circulationCollagen fiberGallus domesticus - A+++2019
New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System
Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C KonjeThis study investigated the role of the endocannabinoid system in the development of uterine leiomyomas, commonly known as fibroids. Researchers analyzed tissue samples and found that the expression of specific receptor…
CannabinoidsCannabinoid receptorsuterine myomfibroids - A++2019
Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats
Marta Toral, Iñaki Robles Vera, Néstor de la Visitación, Miguel Romero, Manuel Sánchez, Manuel Gómez Guzmán, Alba Rodri…This animal study investigated the link between gut bacteria, the immune system, and blood pressure in rats. Researchers transplanted gut microbiota between spontaneously hypertensive rats and rats with normal blood pre…
hypertensionendothelial dysfunctiongut dysbiosisimmune cells - A++2019
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis
Harri Hemilä, Elizabeth ChalkerThis meta-analysis reviewed data from 18 controlled trials involving over 2000 patients to assess if vitamin C affects the length of stay in the intensive care unit (ICU). The results suggest that vitamin C supplementat…
antioxidants; burns; artificial respiration; cardiac surgical procedures; cardiovascular system; critical care; dietary supplements; oxidative stress; sepsis; systematic review - A2019
Innervation of the thoracolumbar fascia
Siegfried MenseThis study, conducted primarily on rats, investigated the types of nerves in the thoracolumbar fascia (TLF) to better understand its sensory roles. Researchers found only free nerve endings, many of which are associated…
NociceptionThoracolumbar fasciainnervationfree nerve endingsproprioception - A++2019
Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients
Stephan F E Praet, Craig R Purdam, Marijke Welvaert, Nicole Vlahovich, Gregg Lovell, Louise M Burke, Jamie E Gaida, Sil…This pilot study investigated whether supplementing with specific collagen peptides could improve symptoms for patients with chronic Achilles tendinopathy. Participants combined a calf-strengthening program with either…
achilles tendon; microvessels; contrast-enhanced ultrasound; hydrolysed collagen supplementation - B2019
The secret life of proteins
Abigail SawyerThe traditional scientific view has long held that single protein molecules are electrical insulators. However, a recent discovery overturns this belief, suggesting instead that proteins are strong electrical conductors…
AntibodyAntigenConductorElectrica L SignalsProtein - A2019
Bone Broth Unlikely to Provide Reliable Concentrations of Collagen Precursors Compared With Supplemental Sources of Collagen Used in Collagen Research
Rebekah D Alcock, Gregory C Shaw, Louise M BurkeThis study analyzed the amino acid content of bone broth to assess it as a reliable source of collagen precursors, the building blocks the body uses to make collagen. Researchers compared various broths—commercial, home…
gelatine; glycine; ligament; proline; protein; tendon - A2019
Educational Avenues for Promoting Dialog on Fascia
Rebecca L PrattThis article argues that fascia is a critically important, yet often overlooked, organ system in healthcare education. The author highlights fascia's diverse roles in pathology, fluid movement, proprioception, pain perc…
fascia; connective; tissue; curriculum; anatomy - A2019
Putative Primo-Vascular System in Rabbit Placenta
Fatma El-Zahraa A MustafaIn this animal study, researchers investigated the primo vascular system (PVS), a proposed network that may play a role in transport, tissue regeneration, and cell migration. While the PVS has been detected in other rab…
inflammatory cell; placenta; primo vascular system; primo vessel; rabbit. - C2019
Cell Biology: Function Guides Form of Auditory Sensory Cells
Jamis McGrath, Benjamin J PerrinThis study describes how the sensory cells in our ears get their specific shape. These cells have bundles of tiny hair-like structures called stereocilia, arranged like a staircase in rows of decreasing height. The proc…
mechanotransductionauditory sensory cells - A2019
The Primo Vascular System as a Possible Exosomal Route Across the Body: Implications for Tumor Proliferation and Metastasis
Chiara GhironThis literature review proposes a possible link between the primo vascular system (PVS)—a network associated with Traditional Chinese Medicine meridians—and the way cancer spreads. The theory is that exosomes, tiny vesi…
cancer microenvironment; exosomes; hyaluronic acid; primo vascular system; tumor metastasis. - A2019
Ultrasound Imaging of the Fascial Layers
Carmelo Pirri, Carla Stecco, Levent ÖzçakarThis publication, for which a full summary is not yet available, appears to discuss using ultrasound to visualize the body's fascial layers. Ultrasound imaging is a non-invasive technique that provides real-time views o…
ultrasound.fascial layers - A2019
The neural basis of the senses of effort, force and heaviness
Uwe Proske, Trevor AllenThis narrative review explores how we sense effort, force, and heaviness during muscle contraction. Traditionally, these sensations were thought to originate in the brain from copies of motor commands. However, new evid…
Force sense · Proprioception · Muscle spindle · Tendon organ · Motor command · Efference copy · Vibration - A++2019
Fascial Entrapment Neuropathy
ANTONIO STECCO, CARMELO PIRRI, CARLA STECCOThis narrative review explores how fascia can contribute to nerve entrapment syndromes, which cause pain, sensory abnormalities, and weakness. The authors describe how nerves are surrounded by a microenvironment of conn…
nerve; nerve entrapment; fascia; Parsonage-Turner - A+++2019
Tentorium Cerebelli: Muscles, Ligaments, and Dura Mater, Part 1
Bruno Bordoni, Marta Simonelli, Maria Marcella LaganaIn this narrative review, the authors describe the anatomy of the tentorium cerebelli, part of the reciprocal tension membranes that divide areas of the brain. They highlight its connections to the dura mater, ligaments…
fasciafascial systemdura matercraniotentorium cerebelli - A++2019
Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2
Liping Gan, Vladimir Camarena, Sushmita Mustafi, Gaofeng WangIn this study using cell cultures and animal models, researchers investigated how vitamin C might inhibit the spread of triple-negative breast cancer (TNBC). They found that vitamin C, at concentrations achievable throu…
F-actin; HIF-1α; YAP1; hippo pathway; lamellipodia; metastasis; synaptopodin 2; triple-negative breast cancer; vitamin C. - A2019
Fascia thickness, aging and flexibility: is there an association?
Jan Wilke, Veronica Macchi, Raffaele De Caro, Carla SteccoThis study investigated how deep fascia thickness relates to age and flexibility in healthy women. Researchers compared a group of young women with a group of older women, using ultrasound to measure fascia thickness an…
connective tissue; hyaluronic acid; stiffness; myofascial; aging - A++2019
Fascial neuromodulation: an emerging concept linking acupuncture, fasciology, osteopathy and neuroscience
Gianluca BiancoThis conceptual paper presents a model called "fascial neuromodulation" to explain how therapies like acupuncture might work. The author suggests that mechanical signals through the fascial network can influence the ner…
acupunctureosteopathyneuromodulationposturologyfascial system - B2019
Anatomy, Bony Pelvis and Lower Limb, Pelvic Fascia
Marco A Siccardi, Cristina ValleThis anatomical review describes the pelvis not as a rigid, static base, but as a dynamic structure. Applying a biotensegrity model, the authors explain how the pelvic bones are suspended within a complex web of tension…
Pelvispelvic fascia - A2019
Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer
Anastasia G Tavianatou, Ilaria Caon, Marco Franchi, Zoi Piperigkou, Devis Galesso, Nikos K KaramanosThis narrative review explores how hyaluronan (HA), a key component of the extracellular matrix, functions differently depending on its molecular size. Large, high-molecular weight HA has different biological properties…
cancer; CD44; cell signaling; hyaluronan; inflammation; pharmacological targeting; RHAMM - A2019
Role of Hyaluronan in Inflammatory Effects on Human Articular Chondrocytes
Mary K Cowman, Claire Shortt, Shivani Arora, Yuhong Fu, Jemma Villavieja, Jai Rathore, Xiayun Huang, Tatini Rakshit, Gy…Some researchers have proposed that fragments of hyaluronan (HA), a key molecule in connective tissue, can trigger inflammation in cartilage. This study investigated that idea in human articular cartilage cells. Researc…
hyaluronan; hyaluronidase; articular cartilage; chondrocytes; inflammation - A+++2019
Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts
Thivanka Muthumalage, Irfan RahmanThis laboratory study investigated how cannabidiol (CBD) influences inflammatory responses in lung epithelial cells, fibroblasts, and immune cells. The researchers found that CBD can reduce inflammation triggered by ext…
CBD; E-cigarette; E-liquid; Lung; Marijuana; Vaping - A2019
Distinct fibroblast subsets drive inflammation and damage in arthritis
Adam P Croft, Joana Campos, Kathrin Jansen, Jason D Turner, Jennifer Marshall, Moustafa Attar, Loriane Savary, Corinna…This study in mice investigated the role of fibroblasts, a type of connective tissue cell, in arthritis. Researchers identified two distinct subsets of fibroblasts with different functions. One type, located in the syno…
Synovial fibroblasts; inflammation; arthritis; transcriptomics; rheumatoid arthritis