Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A+++2020
Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19
Mithila Farjana, Akhi Moni, Abdullah Al Mamun Sohag, Adeba Hasan, Abdul Hannan, Golzar Hossain, Jamal UddinThis narrative review explores the potential of Vitamin C (L-ascorbic acid) for managing complications associated with COVID-19. The authors highlight its known functions, including antioxidant, anti-inflammatory, and i…
COVID-19; SARS-CoV-2; Vitamin C; Immune response; In!ammation - A2020
Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation
Andrew E Miller, Ping Hu, Thomas H BarkerThis narrative review describes how cells and their surrounding environment, the extracellular matrix (ECM), constantly communicate with each other. This communication involves physical cues from the ECM being translate…
extracellular matrixstiffnesscytoskeletonmechanotransduction - A+++2020
Perspective: Vitamin D deficiency and COVID-19 severity –plausibly linked by latitude, ethnicity, impacts on cytokines,ACE2 and thrombosis
J M Rhodes, S Subramanian, E Laird, G Griffin, R A KennyThis narrative review explores the potential link between vitamin D deficiency and the severity of COVID-19. The authors observed that countries at higher latitudes, with less sun exposure, had higher COVID-19 mortality…
cytokineCOVID-19vitamin D - A2020
Iliopsoas muscle thickness and pelvic alignment in pronated and normal foot postures
Zinat Ashnagar, Mohammad-Reza Hadian, Gholamreza Olyaei, Saeed Talebian, Asghar Rezasoltani, Hassan Saeedi, Mir Saeed Y…This study investigated whether chronic foot hyperpronation is linked to changes in pelvic alignment and iliopsoas muscle thickness. Researchers compared a group of women with pronated feet to a group with normal foot p…
Hyperpronation; Iliopsoas; Pelvic angle; Ultrasound imaging. - A+++2020
Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases
Paweł Śledziński, Agnieszka Nowak-Terpiłowska, Joanna ZeylandThis narrative review explores how cannabinoids, including those from plants and those produced naturally by the body, influence health through the endocannabinoid system. The authors describe how these compounds intera…
cancer medicine; cannabinoid receptors; cannabinoids; immune medicine - A++2020
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo ZouThis study using mouse models investigates how the protein PIEZO1 acts as a mechanical sensor in the skeleton to regulate bone mass. Researchers found that a deficiency of PIEZO1 in bone-forming cells (osteoblasts) lead…
mechanotransductionpiezobone homeostasis - A+++2020
Propolis-induced exclusion of colloids: Possible new mechanism of biological action
Magdalena Kowacz, Gerald H PollackThis laboratory study investigates how propolis (bee glue) interacts with water to create an exclusion zone (EZ)—a layer of water that repels solutes and microorganisms. The researchers found that surfaces coated with p…
Colloid-surface repulsion; Exclusion zone; Propolis - A2019
Fascial Nomenclature: Update on Related Consensus Process
Robert Schleip, Gil Hedley, Can A YucesoyThe term "fascia" is increasingly used across different health-oriented fields, but often inconsistently, which causes confusion. To address this, the Fascia Research Society established a Fascia Nomenclature Committee.…
fascia; terminology; Delphi technique; nomenclature; connective tissue - A+++2019
Vitamin C: an essential “stress hormone” during sepsis
Paul E MarikThe body's stress response involves hormones like cortisol and catecholamines, but in most mammals, it also includes increased production of vitamin C. These substances work together to protect the body from damage duri…
Sepsis; vitamin C; HPA axis; stress response - A2019
Improving the New Definition of Fascial System
Bruno BordoniThis narrative review proposes expanding the definition of the fascial system to include bone tissue. The author argues that bone, a specialized form of connective tissue, shares the same embryological origins as other…
fasciaChiropracticosteopathyManual Therapyfascial system - A2019
Intravascular heavy chain-modification of hyaluronan during endotoxic shock
Kevin Ni, Amar Gill, Danting Cao, Kengo Koike, Kelly S Schweitzer, Stavros Garantziotis, Irina PetracheIn this animal study, researchers investigated why a specific molecule, HC-modified hyaluronan (HC-HA), is critical for survival in systemic inflammation (like endotoxic shock) but less so in localized lung inflammation…
Hyaluronic acidInter-alpha-inhibitorSerum-derived hyaluronan-associated proteinTNFα stimulated gene 6Endotoxic shock - A2019
Fascial Nomenclature: An Update
Bruno Bordoni, Stevan Walkowski, Bruno Morabito, Matthew A VaracalloThis review article discusses the ongoing challenge of creating a single, comprehensive definition for fascia. The authors argue that different scientific and clinical fields view fascia through their own unique lenses,…
fasciamechanotransductionMyofascialOsteopathicphysiotherapy - A2019
Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor
Stephan Thönes, Sandra Rother, Tom Wippold, Joanna Blaszkiewicz, Kanagasabai Balamurugan, Stephanie Moeller, Gloria Rui…This study investigated a new type of hydrogel designed to improve wound healing. Researchers combined collagen and hyaluronan (HA), a natural component of connective tissue, with a growth factor that stimulates skin ce…
Biomimetic material; Extracellular matrix (ECM); Fibroblasts; Heparin-binding epidermal growth factor-like growth factor (HB-EGF); Hyaluronan; Hydrogel; Sulfated hyaluronan; Surface plasmon resonance; Wound healing. - A2019
Tissue Regeneration from Mechanical Stretching of Cell–Cell Adhesion
Amir Monemian Esfahani, Jordan Rosenbohm, Keerthana Reddy, Xiaowei Jin, Tasneem Bouzid, Brandon Riehl, Eunju Kim, Jung…This narrative review explores how mechanical stretching can stimulate tissue regeneration and wound healing. Researchers have long known that cells respond to mechanical forces, but much of the focus has been on the co…
wound healingmechanotransductioncell–cell adhesionmechanical stretchingtissue regeneration - A+2019
Overuse Injury: The Result of Pathologically Altered Myofascial Force Transmission?
Jan Wilke, Andry Vleeming, Scott WearingIn this narrative review, the authors propose a new perspective on overuse injuries. Traditionally, therapy focuses on the site of pain, viewing the injury as the result of local, repetitive microdamage. The authors hyp…
Myofascial force transmissionoveruse injuryfascitismusculoskeletal disorder - B2019
Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology
Saba Nayar, Joana Campos, Charlotte G Smith, Valentina Iannizzotto, David H Gardner, Frédéric Mourcin, David Roulois, J…In sites of chronic inflammation or infection, connective tissue cells called fibroblasts can change their behavior. This study shows how a specific group of fibroblasts transforms into a network of so-called "immunofib…
FibroblastsSjögren’s syndromeautoimmunitytertiary lymphoid structures - A++2019
Observation using thermography of post-operative reaction after fascial manipulation®
Joanna Fidut-Wrońska, Kamil Chołuj, Justyna Chmiel, Katarzyna Pikto-Pitkiewicz, Piotr MajcherThis study investigated whether Fascial Manipulation® causes a local increase in skin temperature, which is theorized to be part of its mechanism. Researchers used a thermal-imaging camera to measure skin temperature in…
inflammationFascial manipulationthermography - A+++2019
Tentorium Cerebelli: Muscles, Ligaments, and Dura Mater, Part 1
Bruno Bordoni, Marta Simonelli, Maria Marcella LaganaIn this narrative review, the authors describe the anatomy of the tentorium cerebelli, part of the reciprocal tension membranes that divide areas of the brain. They highlight its connections to the dura mater, ligaments…
fasciafascial systemdura matercraniotentorium cerebelli - A+++2019
Vitamin C and Neutrophil Function: Findings from Randomized Controlled Trials
Mikee Liugan, Anitra C CarrThis systematic review examined how vitamin C supplementation affects neutrophils, a key type of immune cell. Researchers analyzed 16 randomized controlled trials that measured neutrophil functions like their ability to…
vitamin C; ascorbic acid; neutrophils; polymorphonuclear leukocytes; migration; chemotaxis; apoptosis; phagocytosis; oxidative burst; systematic review - A2019
Mechanobiology of cells and cell systems, such as organoids
Ece Bayir, Aylin Sendemir, Yannis F MissirlisThis review discusses organoids, which are three-dimensional tissues grown in a lab that self-organize to mimic organ development. While organoids offer great potential for disease modeling and drug development, little…
mechanotransductionmechanobiologyOrganoidMechanoepigeneticsCollective cell behavior - A2019
Anatomy, Fascia
Bruno Bordoni, Navid Mahabadi, Matthew VaracalloThis resource provides an overview of the anatomy of fascia. As the full text has not yet been reviewed, this summary is based on the title alone. The entry likely covers the structural and functional aspects of fascial…
fascia - A++2019
Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats
Marta Toral, Iñaki Robles Vera, Néstor de la Visitación, Miguel Romero, Manuel Sánchez, Manuel Gómez Guzmán, Alba Rodri…This animal study investigated the link between gut bacteria, the immune system, and blood pressure in rats. Researchers transplanted gut microbiota between spontaneously hypertensive rats and rats with normal blood pre…
hypertensionendothelial dysfunctiongut dysbiosisimmune cells - A2019
Cellular nanoscale stiffness patterns governed by intracellular forces
Nicola Mandriota, Claudia Friedsam, John A Jones-Molina, Kathleen V Tatem, Donald E Ingber, Ozgur SahinCell stiffness is important in many biological processes, but its precise relationship to the forces acting inside the cell has been unclear. In this study, researchers developed a new high-resolution imaging platform t…
Tensegritymechanotransductioncell - cell interaction - A++2019
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis
Harri Hemilä, Elizabeth ChalkerThis meta-analysis reviewed data from 18 controlled trials involving over 2000 patients to assess if vitamin C affects the length of stay in the intensive care unit (ICU). The results suggest that vitamin C supplementat…
antioxidants; burns; artificial respiration; cardiac surgical procedures; cardiovascular system; critical care; dietary supplements; oxidative stress; sepsis; systematic review - A2019
Association of thoraco-lumbar fascia length in individuals with non-specific low back pain - an observational study
Shellette D' Almeida, Charu Eapen, Shyam KrishnanThis observational study compared 31 people with non-specific low back pain to 31 healthy individuals to investigate the thoracolumbar fascia (TLF). Researchers measured TLF length by assessing lumbar spine rotation, an…
low back painthoracolumar fascia lenght - A2019
The neural basis of the senses of effort, force and heaviness
Uwe Proske, Trevor AllenThis narrative review explores how we sense effort, force, and heaviness during muscle contraction. Traditionally, these sensations were thought to originate in the brain from copies of motor commands. However, new evid…
Force sense · Proprioception · Muscle spindle · Tendon organ · Motor command · Efference copy · Vibration - A2019
Lymphatic pump manipulation in patients with chronic obstructive pulmonary disease
Bruno BordoniThis narrative review examines the use of lymphatic pump manipulation for patients with chronic obstructive pulmonary disease (COPD). COPD is characterized by persistent inflammation, and lymphatic techniques aim to red…
inflammationfasciaOsteopathicCOPDlymphatic pump - A+2019
Ultrasound-detected connective tissue involvement in acute muscle injuries in elite athletes and return to play: The French National Institute of Sports (INSEP) study
Jérôme Renoux, Jean-Louis Brasseur, Mathilde Wagner, Alain Frey, Dominique Folinais, Christian Dibie, Djamila Maiza, Mi…This study examined 70 elite athletes with acute muscle injuries. Researchers used ultrasound within seven days to assess injury severity and to see if connective tissue was involved. They then tracked the time it took…
ultrasound.return to playMuscle injuriesConnective tissue injury - A2019
Hierarchical Hydrogel Composite Interfaces with Robust Mechanical Properties for Biomedical Applications
Yuting Zhu, Qiang Zhang, Xiaoli Shi, Dong HanThis review summarizes advances in hydrogel composites, materials designed to mimic the body's extracellular matrix (ECM). Cells naturally sense and respond to the mechanical properties and physical structure of the ECM…
tissue engineeringECMHydrogels - A2019
Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model
S Azizi, A Farsinejad, R Kheirandish, H FatemiThis animal study investigated a potential treatment for osteoarthritis (OA) in rats. Researchers induced OA in the rats' knees and then treated them with intra-articular injections. One group received a combination of…
Osteoarthritis; SRGF; Monosodium iodoacetate; Vitamin C; Histopathology - 1A+2019
The Awareness of the Fascial System
Bruno Bordoni, Marta SimonelliIn this theoretical article, the authors propose a new way of looking at the fascial system, drawing on concepts from quantum physics. They suggest that fascial cells can sense, remember, and even anticipate mechanical…
fasciafascial systemMyofascialquantum physicsphysiology - A++2019
Mitochondrial superoxide anions induced by exogenous oxidative stress determine tumor cell fate: an individual cell-based study
Hui PAN, Bao-hui WANG, Zhou-bin LI, Xing-guo GONG, Yong QIN, Yan JIANG, Wei-li HANIn this cell-based study, researchers investigated how external oxidative stress affects individual lung cancer cells. They found that applying a stressor like hydrogen peroxide caused a rapid increase in reactive oxyge…
Individual cell; Superoxide anion; Reactive oxygen species (ROS) dynamics; Intrinsic apoptotic pathway; Ca2+ signaling - 1A+2019
The fascial breath
Bruno Bordoni, Marta Simonelli, Bruno MorabitoThis narrative review proposes a new way of understanding the diaphragm muscle, moving beyond a purely mechanical view. The authors argue that the diaphragm is not just covered by fascia but is fundamentally a fascial t…
fasciaMyofascialOsteopathicdiaphragmbreathing - A2019
Bone Broth Unlikely to Provide Reliable Concentrations of Collagen Precursors Compared With Supplemental Sources of Collagen Used in Collagen Research
Rebekah D Alcock, Gregory C Shaw, Louise M BurkeThis study analyzed the amino acid content of bone broth to assess it as a reliable source of collagen precursors, the building blocks the body uses to make collagen. Researchers compared various broths—commercial, home…
gelatine; glycine; ligament; proline; protein; tendon - A2019
A Systematic Review of the Morphology and Function of the Sacrotuberous Ligament
DANIELA ALDABE , NIELS HAMMER, NATASHA A M S FLACK, STEPHANIE J WOODLEYThis systematic review examined existing research on the sacrotuberous ligament (STL) to clarify its anatomy and function. The STL is often implicated in conditions like pelvic girdle pain, but its exact role has been d…
anatomy; pelvis; ligament; review - 1A+2019
The Other Side of the Fascia: The SmoothMuscle Part 1
Bruno Bordoni, Marta Simonelli, Bruno MorabitoThis theoretical article challenges the standard definition of fascia. Traditionally, fascia is considered connective tissue originating from two embryonic layers, the mesoderm and ectoderm. The authors propose expandin…
fasciaMyofascialOsteopathicsmooth musclemesoderm - 1A++2019
Evaluation of hyaluronan content in areas of densification compared to adjacent areas of fascia
E J Hughes, K McDermott, M F FunkThis entry is currently a title only, so a full summary is not available. Based on the title, the researchers appear to have evaluated and compared the hyaluronan content in areas of fascial densification with the conte…
hyaluronanfasciadensificationcenters of coordination - 1A+2019
The Other Side of the Fascia: Visceral Fascia, Part 2
Bruno Bordoni, Marta Simonelli, Bruno MorabitoThis editorial, part two of a series, argues for including certain internal organs (viscera) within the definition of fascia. From an osteopathic perspective, the authors suggest that understanding these organs as fasci…
fasciaMyofascialOsteopathicsmooth musclemesoderm - A++2019
Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2
Liping Gan, Vladimir Camarena, Sushmita Mustafi, Gaofeng WangIn this study using cell cultures and animal models, researchers investigated how vitamin C might inhibit the spread of triple-negative breast cancer (TNBC). They found that vitamin C, at concentrations achievable throu…
F-actin; HIF-1α; YAP1; hippo pathway; lamellipodia; metastasis; synaptopodin 2; triple-negative breast cancer; vitamin C. - A++2019
Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients
Stephan F E Praet, Craig R Purdam, Marijke Welvaert, Nicole Vlahovich, Gregg Lovell, Louise M Burke, Jamie E Gaida, Sil…This pilot study investigated whether supplementing with specific collagen peptides could improve symptoms for patients with chronic Achilles tendinopathy. Participants combined a calf-strengthening program with either…
achilles tendon; microvessels; contrast-enhanced ultrasound; hydrolysed collagen supplementation - A+++2019
New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System
Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C KonjeThis study investigated the role of the endocannabinoid system in the development of uterine leiomyomas, commonly known as fibroids. Researchers analyzed tissue samples and found that the expression of specific receptor…
CannabinoidsCannabinoid receptorsuterine myomfibroids - A++2019
Rehabilitation and nutrition protocols for optimising return to play from traditional ACL reconstruction in elite rugby union players: A case study
Gregory Shaw, Ben Serpell, Keith BaarThis case report followed two professional rugby players undergoing rehabilitation after an anterior cruciate ligament (ACL) reconstruction. In addition to a standard rehabilitation program, they received specific suppl…
collagenRehabilitationnutritionACL - A++2019
Plasma Amino Acid Concentrations After the Ingestion of Dairy and Collagen Proteins, in Healthy Active Males
Rebekah D Alcock, Gregory C Shaw, Nicolin Tee, Louise M BurkeThis study investigated how blood amino acid levels changed in healthy, active men after they consumed either collagen or dairy proteins. Researchers found that the different protein sources led to distinct amino acid p…
Connective tissuetendonligamentprolineleucine - A+++2019
Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts
Thivanka Muthumalage, Irfan RahmanThis laboratory study investigated how cannabidiol (CBD) influences inflammatory responses in lung epithelial cells, fibroblasts, and immune cells. The researchers found that CBD can reduce inflammation triggered by ext…
CBD; E-cigarette; E-liquid; Lung; Marijuana; Vaping - A2019
The effects of vibration-induced altered stretch reflex sensitivity on maximal motor unit firing properties
Alejandra Barrera-Curiel, Ryan J Colquhoun, Jesus A Hernandez-Sarabia, Jason M DeFreitasResearchers investigated how muscle vibration, which affects the stretch reflex, influences muscle strength and nerve signals during maximal effort. In a study with 24 participants performing maximal knee extensions, th…
group Ia afferents; muscle spindle function; muscle vibration - A2019
Glut-1 explains the evolutionary advantage of the loss of endogenous vitamin C-synthesis
Tabea C Hornung, Hans-Konrad BiesalskiUnlike many animals, humans cannot produce their own vitamin C. This study explores a potential evolutionary advantage of this loss. Researchers compared red blood cells from humans and pigs (who can make vitamin C) and…
glucose transporter; vitamin C; gulono-lactone-oxidase; vitamin C recycling - A2019
Imaging of ultraweak photon emission for evaluating the oxidative stress of human skin
Katsuhiko Tsuchidaa, Torai Iwasab, Masaki KobayashiThis study explored a method for visualizing oxidative stress in human skin by imaging ultraweak photon emission (UPE), also known as biophotons. Researchers found that exposing skin to UV radiation increased the intens…
BiophotonOxidationImagingNon-invasiveUltraviolet - A2019
Age-related changes in leg proprioception: implications for postural control
Mélanie Henry, Stéphane BaudryThis narrative review examines how aging affects proprioception—the body's sense of its own position and movement—and its implications for balance. To maintain an upright stance, the brain relies on signals from recepto…
proprioceptionmuscle spindlesbalanceIa afferentsupright standing - C2019
Cell Biology: Function Guides Form of Auditory Sensory Cells
Jamis McGrath, Benjamin J PerrinThis study describes how the sensory cells in our ears get their specific shape. These cells have bundles of tiny hair-like structures called stereocilia, arranged like a staircase in rows of decreasing height. The proc…
mechanotransductionauditory sensory cells - A2019
Active Contractile Properties of Fascia
ROBERT SCHLEIP, WERNER KLINGLERThis narrative review explores how fascia, often seen as a passive tissue, can actively contract. Researchers point to the presence of cells called myofibroblasts within the fascia, which give it the ability to change i…
myofibroblast; fascia; connective tissue; contracture; stiffness; fibrosis - C2019
Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain
Chu-Ting Chang, Sitt Wai Fong, [...], Chih-Cheng ChenIn this animal study, researchers investigated the role of a specific ion channel, called ASIC1b, in the development of chronic muscle pain. They created a fibromyalgia-like condition by injecting acid into the leg musc…
FibromyalgiapainASICASIC1bASIC3 - A2019
Cranial osteopathy: Obscurantism and Enlightenment
Bruno Bordoni, Bruno Morabito, Marta SimonelliIn this reflective article, the authors discuss the controversial aspects of cranial osteopathy. They address common objections, such as the idea that the cranial bones are immobile in adults and that an operator's hand…
fasciaOsteopathicquantum physicsneurophysiologycranio - A++2019
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure
Alpha A Fowler, Jonathon D Truwit, R Duncan Hite, Peter E Morris, Christine DeWilde, Anna Priday, Bernard Fisher, Leroy…This randomized controlled trial investigated whether intravenous vitamin C could help patients with sepsis and severe acute respiratory failure. Researchers gave 167 patients either a high-dose vitamin C infusion or a…
sepsisintravenous vitamin C - A+++2019
Future Aspects for Cannabinoids in Breast Cancer Therapy
Terézia Kisková, Felicitas Mungenast, Mária Suváková, Walter Jäger, Theresia ThalhammerThis scientific review explores how cannabinoids, such as THC and CBD, may influence breast cancer beyond their established role in palliative care for pain and nausea. Research suggests that cannabinoids might decelera…
CBD; Cannabis sativa; THC; breast cancer; cannabidiol; cannabinoid receptor; delta-9-tetrahydrocannabinol - A+++2019
Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury
Enrico Sangiovanni, Marco Fumagalli, Barbara Pacchetti, Stefano Piazza, Andrea Magnavacca, Saba Khalilpour, Gloria Melz…This in vitro study investigated how Cannabis sativa extract and its component cannabidiol (CBD) affect inflammation in human skin cells. Researchers found that both the extract and pure CBD reduced the release of sever…
Cannabis sativa L.; cannabidiol; fibroblasts; keratinocytes; skin inflammation; wound injury. - A2019
Benefits of adding stretching to a moderate-intensity aerobic exercise programme in women with fibromyalgia: a randomized controlled trial
Miguel Gómez-Hernández, Tomás Gallego-Izquierdo, Patricia Martínez-Merinero, Daniel Pecos-Martín, Alejandro Ferragut-Ga…This randomized controlled trial investigated whether adding stretching to a moderate-intensity aerobic exercise program provided extra benefits for women with fibromyalgia. One group performed moderate aerobic exercise…
FibromyalgiaStretchingpainsleep qualityquality of life - 1A+2019
Fascia Is Able to Actively Contract and May Thereby Influence Musculoskeletal Dynamics: A Histochemical and Mechanographic Investigation
Robert Schleip, G Gabbiani, Jan Wilke, I Naylor, B Hinz, A Zorn, Heike Jäger, R Breul, S Schreiner, Werner KlinglerThis study investigated whether fascia can actively contract, challenging the traditional view of it as a passive tissue. Researchers examined human and rat fascial samples for the presence of contractile cells called m…
Connective tissuestiffnessmyofibroblastscontractilitycontracture - A++2019
Acute Effects of Static Stretching on Muscle Strength and Power: An Attempt to Clarify Previous Caveats
Helmi Chaabene, David G Behm, Yassine Negra, Urs GranacherThis narrative review examines how static stretching affects subsequent strength and power. While static stretching was once thought to hinder performance, recent evidence suggests the duration of the stretch is the cri…
physiologyrange of motioninjurypassive stretchingphysical fitness - A2019
The Primo Vascular System as a Possible Exosomal Route Across the Body: Implications for Tumor Proliferation and Metastasis
Chiara GhironThis literature review proposes a possible link between the primo vascular system (PVS)—a network associated with Traditional Chinese Medicine meridians—and the way cancer spreads. The theory is that exosomes, tiny vesi…
cancer microenvironment; exosomes; hyaluronic acid; primo vascular system; tumor metastasis. - B2019
Stiffness and echogenicity: Development of a stiffness-echogenicity matrix for clinical problem solving
Antonio Stecco, Carmelo Pirri, Raffaele De Caro, Preeti RaghavanAssessing soft tissue stiffness is important for many neuromusculoskeletal conditions, but can be challenging. While ultrasound can measure a tissue's echogenicity (how it reflects sound waves), this is not directly pro…
stiffnessultrasound.Elastographyechogenicity