Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- C2017
Bi component T1p and T2 Relaxation Mapping of Skeletal Muscle In-Vivo
Azadeh Sharafi, Gregory Chang, Ravinder R RegatteResearchers evaluated a specific MRI technique for creating more detailed images of skeletal muscle. Using what is known as T1ρ and T2 relaxation mapping on the calf muscles of healthy volunteers, they were able to dist…
inflammationfibrosisskeletal musclebi-componentT2 relaxation - A+++2017
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J…This randomized controlled trial examined the effects of a fasting-mimicking diet (FMD) on risk factors for age-related diseases in 100 healthy participants. For five consecutive days each month over a three-month perio…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; cancer; diabetes; cardiovascular disease - A+++2017
Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study
John F Pearson, Juliet M Pullar, Renee Wilson, Janet K Spittlehouse, Margreet C M Vissers, Paula M L Skidmore, Jinny Wi…This cohort study examined vitamin C status in 404 fifty-year-olds in New Zealand. Researchers measured the concentration of vitamin C in participants' blood plasma as well as their dietary intake. The results showed th…
ascorbate; cognition; HbA1c; insulin; glucose; hypovitaminosis C - B2017
Complex mechanics of the heterogeneous extracellular matrix in cancer
Andrea Malandrino, Michael Mak, Roger D Kammd, Emad MoeendarbaryThis narrative review explores the complex role of the extracellular matrix (ECM), the non-cellular network that provides structural support to tissues. In solid tumors, the ECM becomes highly altered and complex, as ca…
extracellular matrixCell signalingtumor microenvironment - C2017
Fibronectin in cell adhesion and migration via N-glycosylation
Cheng-Te Hsiao, Hung-Wei Cheng, Chi-Ming Huang, Hao-Ru Li, Meng-Hsin Ou, Jie-Rong Huang, Kay-Hooi Khoo, Helen Wenshin Y…Fibronectin is a protein in blood plasma that helps cells stick together and move, a process essential for wound healing. This study investigated how a specific chemical modification, called N-glycosylation, affects fib…
wound healingcell migrationFibronectincell adhesion - A2017
The myodural bridge existing in the Nephocaena phocaenoides
Pei Liu, Chan Li, Nan Zheng, Qiang Xu, Sheng-Bo Yu, Hong-Jin SuiThe myodural bridge is a connection between a small neck muscle and the spinal cord's outer covering (the dura mater) previously identified in humans. In this anatomical animal study, researchers investigated whether a…
dura materMyodural Bridge - C2017
Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin
Patricia Paracuellos, Sebastian Kalamajski, Arkadiusz Bonnac, Dominique Bihanc, Richard W. Farndale, Erhard HohenesterFibromodulin and chondroadherin are small proteins that help organize the extracellular matrix. This study examined their 3D structure and how they interact with collagen. Researchers found that while their overall shap…
Cell signalingfibromodulinchondroadherinextra cellular matrix - A2017
Spontaneous photon emission: A promising non-invasive diagnostic tool for breast cancer
Xiaolei Zhao, Jingxiang Pang, Jialei Fu, Yong Wang, Meina Yang, Yanli Liu, Hua Fan, Liewei Zhang, Jinxiang HanIn this animal study, researchers investigated if ultra-weak light emission from the body, called spontaneous photon emission (SPE), could detect breast cancer. They measured light from the skin of mice with breast canc…
Breast cancerSpontaneous photon emission (SPE)Preliminary screeningCluster analysisOxidative metabolic - A++2017
Oscillations of ultra-weak photon emission from cancer and noncancer cells stressed by culture medium change and TNF-alfa
Pierre Madl, Thomas Verwanger, Mark Geppert, Felix ScholkmannAll cells spontaneously emit a very faint light, known as ultra-weak photon emission (UPE). This study investigated how this light emission changes when different types of human cells, both cancerous and non-cancerous,…
cancerBiophotonultraweak photon emission - A++2017
Measuring ultra-weak photon emission as a non-invasive diagnostic tool for detecting early-stage type 2 diabetes: A step toward personalized medicine
Mengmeng Sun, Eduard Van Wijk, Slavik Koval, Roeland Van Wijk, Min He, Mei Wang, Thomas Hankemeier, Jan van der GreefThis study investigated whether ultra-weak photon emission (UPE)—a very faint light emitted by the body—could help identify different subtypes of pre-diabetes. Researchers had practitioners of Traditional Chinese Medici…
biophotonsTraditional Chinese medicin-based diagnosticsPersonalized medicineType 2 diabetesUltra-weak photon emission (UPE) - A++2017
Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons
Kelsey A Robinson, Mei Sun, Carrie E Barnum, Stephanie N Weiss, Julianne Huegel, Snehal S Shetye, Linda Lin, Daniel Sae…This study on mice investigated the role of two molecules, decorin and biglycan, in maintaining healthy adult tendons. Researchers used a genetic model to remove these molecules from mature patellar tendons after they h…
Tendon; Decorin; Biglycan; Collagen fibril; Fiber realignment; Structure; Mechanical properties; Conditional knockout mice - A+++2017
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Chia-Wei Cheng, Valentina Villani, Roberta Buono, Min Wei, Sanjeev Kumar, Omer H Yilmaz, Pinchas Cohen, Julie B Sneddon…This study, involving mice and human pancreatic cells, explores how cycles of a fasting-mimicking diet (FMD) may influence the pancreas's ability to produce insulin. Researchers found that the diet appears to activate g…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; diabetes - B2017
Cellulite: a review with a focus on subcision
Daniel P Friedmann, Garrett Lane Vick, Vineet MishraThis narrative review examines cellulite, a common skin condition characterized by altered skin topography that primarily affects women on their buttocks and thighs. The authors discuss the potential underlying causes a…
gynoid lipodystrophyfibrous septaeradiofrequencyvacuum-assisted subscision - A++2017
Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis
Min He, Eduard van Wijk, Herman van Wietmarschen, Mei Wang, Mengmeng Sun, Slavik Koval, Roeland van Wijk, Thomas Hankem…In this animal study, researchers investigated a mouse model of rheumatoid arthritis using two techniques: metabolomics (the analysis of metabolic products) and ultra-weak photon emission (UPE), which measures extremely…
biophotonsUltra-weak photon emissionSystems biologyCollagen-induced arthritisCorrelation networks - A+2017
Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
A W Ashor, A D Werner, J Lara, N D Willis, J C Mathers, M SiervoThis systematic review and meta-analysis compiled data from 22 randomized controlled trials to assess the effect of vitamin C supplementation on glycemic control. Overall, the researchers found no significant effect on…
Vitamin Cinsulin resistensglycaemic control - A+++2017
Early versus Delayed Rehabilitation after Acute Muscle Injury
Monika L Bayer, Peter Magnusson, Michael KjaerThis research entry, titled "Early versus Delayed Rehabilitation after Acute Muscle Injury," is currently awaiting a detailed summary. The title suggests it explores the optimal timing for starting rehabilitation follow…
Rehabilitationmuscle injurymechanical loading in rehabilitation - A2017
Rectus Capitis Posterior Minor
Gabriel Venne, Brian J Rasquinha, Manuela Kunz, Randy E EllisThis cadaver study investigated the connection between a small neck muscle (Rectus Capitis Posterior Minor, RCPMi) and the spinal dura mater. Researchers used both microscopic analysis and biomechanical testing to clari…
biomechanical testingcervical dura matermechanical influence of musclesmechanical influence of soft tissuerectus capitis posterior minor - C2017
Concurrent validity of pain scales in individuals with myofascial pain and fibromyalgia
Scott W Cheatham, Morey J Kolber, Monique Mokha, William J HanneyResearchers investigated the reliability of two common tools for measuring pain: the Numeric Pain Rating Scale (NPRS), where patients rate pain from 0 to 10, and the Visual Analog Scale (VAS). The study included 60 part…
Myofascial painFibromyalgiapain scales - B2017
Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
Masahiro Ohgidani, Takahiro A Kato, Masako Hosoi, Makoto Tsuda, Kohei Hayakawa, Chie Hayaki, Rie Iwaki, Noriaki Sagata,…Researchers are investigating the role of brain immune cells called microglia in fibromyalgia. This study used a new technique to create microglia-like cells from the blood of people with fibromyalgia and healthy indivi…
Fibromyalgiamikroglia - B2017
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma
Emmanuel Bäckryd, Lars Tanum, Anne-Li Lind, Anders Larsson, Torsten GordhThis study investigated signs of inflammation in people with fibromyalgia (FM). Researchers analyzed 92 different inflammation-related proteins in both blood plasma and cerebrospinal fluid from 40 FM patients, comparing…
inflammationFibromyalgiacytokineschronic paincerebrospinal fluid - A2017
Does the vaginal wall become thinner as prolapse grade increases?
Rhiannon Bray, Alex Derpapas, Ruwan Fernando, Vik Khullar, Demetri C PanayiThis study investigated the relationship between vaginal wall thickness and the severity of pelvic organ prolapse. Researchers used ultrasound to measure the vaginal walls of 243 women with symptomatic prolapse. They fo…
Prolapse . Ultrasonography . Vaginal wall thickness - B2017
The Application of Acoustic Myography in Canine Muscle Function and Performance Testing
Christina Fenger, Adrian P HarrisonThis animal study on 11 Labrador dogs used acoustic myography (AMG) to measure muscle activity during walking and trotting. Researchers focused on two muscles, the m. gluteus superficialis and m. longissimus lumborum, t…
Mechanomyographym.longissimusm.glutealDogMuscle contraction - A2017
We are operating too much
Nicola MaffulliIn this editorial, the author, an orthopedic and trauma surgeon, observes a rising number of operations for orthopedic and trauma ailments. He notes that this trend runs counter to the results of high-quality studies, w…
Surgery - A2017
Semimembranosus Muscle Injuries In Sport. A Practical MRI use for Prognosis
Ramon Balius, Mireia Bossy, Carles Pedret, Lluis Capdevila, Xavier Alomar, Bryan Heiderscheit, Gil RodasThis retrospective study investigated whether MRI scans could help predict recovery time for athletes with injuries to the semimembranosus, one of the hamstring muscles. Researchers analyzed MRI scans from 19 athletes,…
MRIreturn to playsemimembranosushamstring injuries - A2017
CT arthrography of adhesive capsulitis of the shoulder: Are MR signs applicable?
Milena Cernya, Patrick Omoumia, Ahmed Larbi, Daniel Manicourt, Anne Perozziello, Frédéric Lecouvet, Bruno Vande Berg, B…This retrospective study investigated whether signs of adhesive capsulitis (frozen shoulder) typically seen on MRI could also be identified using CT arthrography (CTA). Researchers compared CTA scans from 22 patients wi…
frozen shoulderAdhesive capsulitisArthrographyRotator intervalCTA - A++2017
NAD and the aging process: Role in life, death and everything in between
Claudia C S Chini, Mariana G Tarragó, Eduardo N ChiniThis narrative review explores the vital role of the molecule NAD in cellular health and the aging process. Beyond its traditional role in metabolism, NAD is essential for cell signaling and regulating the epigenetic st…
Aging; CD38; Mitochondrial function; NAD(+); PARP; SIRTUINS - A2017
Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease
Rutger A F Gjaltema, Ruud A BankThis narrative review provides an updated overview of the complex process of creating mature collagen. The formation of collagen fibrils from precursor molecules involves many enzymes and chaperones in a series of steps…
Bruck syndrome; Collagen; Ehlers–Danlos syndrome; connective tissue disorders; fibrosis; lysyl hydroxylation; osteogenesis imperfecta; prolyl hydroxylation. - A+2017
The nature and biology of basement membranes
Ambra Pozzi, Peter D Yurchenco, Renato V IozzoThis review article discusses the nature and biology of basement membranes. These are thin, flexible sheets of tissue that line and separate different structures in the body. Once thought to be just passive scaffolding,…
Collagen; laminin; heparan sulfate proteoglycan; discoidin domain receptor; integrin - B2017
Mechanical properties of a collagen fibril under simulated degradation
David C Malaspinaa, Igal Szleifera, Yasin DhaheraThis study used computer simulations to investigate how collagen fibrils lose their strength. Researchers modeled three different types of degradation: the removal of cross-links, surface damage, and damage throughout t…
collagenMolecular dynamicsDegradationMMP - A+++2017
Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation
Benoit Chassaing, Tom Van de Wiele, Jana De Bodt, Massimo Marzorati, Andrew T GewirtzThis study investigated how common food additives, specifically the emulsifiers polysorbate 80 (P80) and carboxymethylcellulose (CMC), affect the gut microbiota. Using a laboratory model of the human intestinal ecosyste…
INFLAMMATION; INTESTINAL MICROBIOLOGY - A++2017
Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments
Keith BaarMusculoskeletal injuries are a primary reason for time away from sports, partly because our understanding of how training affects tendons and ligaments is limited. This study used engineered ligaments grown in a lab fro…
trainingminimizing injuryreturn to playsupplementation - A++2017
Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels
Jason Wu, Amanda H Lewis, Jörg GrandlThis narrative review explores Piezo1 and Piezo2, specialized proteins that act as the body's primary mechanical sensors. These ion channels convert physical forces like touch, tension, and fluid flow into electrical si…
Mechanotransductionpiezo - A2017
The indeterminable resilience of the fascial system
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice SacconiThis commentary proposes a model of fascia not as layers, but as a network of polyhedral microvacuoles of connective tissue. These structures connect the body's systems and can change shape in response to tension, allow…
fasciafibroblastManual TherapyOsteopathicfascial continuum - A++2017
Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice
Zhenbin Wang, Qing Wang, Lin Wang, Weidong Xu, Yuanqing He, Yunliang Li, Song He, Haile MaThis animal study investigated how oral supplementation of collagen hydrolysates derived from fish scales affected chronological skin aging in mice over six months. The researchers found that mice receiving collagen in…
chronological aging; collagen hydrolysates; histological structure; oxidative stress; skin condition; visual appearance - A2017
The significance of closed kinematic chains to biological movement and dynamic stability
Stephen Levin, Susan Lowell de Sol!orzano, Graham ScarrBiomechanical research has long focused on the body as a system of levers, but this review highlights the importance of "closed kinematic chains" (CKCs). These are continuous mechanical loops that couple multiple parts…
biotensegrityBiomechanicsClosed-chainDevelopmentEvolution - C2017
X-Rays Effects on Cytoskeleton Mechanics of Healthy and Tumor Cells
Valeria Panzetta, Marta De Menna, Ida Musella, Mariagabriella Pugliese, Maria Quarto, Paolo A. Netti, Sabato FuscoThis study investigated how X-ray radiation affects the internal structure, or cytoskeleton, of both healthy cells and tumor cells in a lab setting. Researchers exposed both cell types to different doses of radiation an…
X-rays; Cytoskeleton; Mechanobiology; Focal Adhesion; Particle Tracking; Microrheology - A+++2017
Activation of type 2 cannabinoid receptor (CB2R) by selective agonists regulates the deposition and remodelling of the extracellular matrix
Tao Guan, Guiyang Zhao, Honghui Duan, Yang Liu, Feng ZhaoThis in vitro study investigated how activating the type 2 cannabinoid receptor (CB2R) affects scar formation in eye connective tissue after surgery. Researchers found that human Tenon’s fibroblasts express these recept…
Matrix metalloproteinase 1 (MMP-1); Tenon’s fibroblasts; Transforming growth factor-β1; Type 2 cannabinoid receptor (CB2R); Wound healing - A2017
Calcium Signaling in Interstitial Cells: Focus on Telocytes
Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Mihai Radu, Dragos Cretoiu, Sanda Maria CretoiuThis narrative review describes current knowledge on calcium signaling in a group of cells called interstitial cells, with a special focus on telocytes. These cells and their calcium signals are important for generating…
telocytesinterstitial cellscalcium signalingCa2+ oscillationspacemaker activity - A2017
Piezoelectric material – A promising approach for bone and cartilage regeneration
Namdev More, Govinda KapusettiThis paper outlines a novel hypothesis for regenerating bone and cartilage, two weight-bearing tissues that are challenging to repair. Current treatments for damage from trauma or diseases like osteoarthritis have signi…
tissue engineeringPiezoelectricityBone regenerationCartilage regeneration - A2017
The Lumbodorsal Fascia as a Potential Source of Low Back Pain: A Narrative Review
Jan Wilke, Robert Schleip, Werner Klingler, Carla SteccoThis narrative review examines the role of the lumbodorsal fascia as a potential source of low back pain. Research shows this fascia contains pain-sensing nerve endings, which may be morphologically altered in people wi…
fasciaNociceptionlow back painlumbodorsal fascia - A2017
Correlation between chronic headaches and the rectus capitis posterior minor muscle: A comparative analysis of cross-sectional trail
Xiao-Ying Yuan, Sheng-Bo Yu, Cong Liu, Qiang Xu, Nan Zheng, Jian-Fei Zhang, Yan-Yan Chi, Xu-Gang Wang, Xiang-Tao Lin, H…Researchers investigated the relationship between chronic headaches and a small muscle at the base of the skull, the rectus capitis posterior minor (RCPmi). Using magnetic resonance imaging (MRI), they compared the size…
Myodural Bridgerectus capitis posterior minor musclechronic headacheshypertrophy - B2017
Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis
Y Xiong, L Berrueta, K Urso, Sara Olenich, Igla Muskaj, G J Badger, A Aliprantis, R Lafyatis, H M LangevinThis animal study investigated the effects of stretching on systemic sclerosis, a condition that causes skin inflammation and fibrosis. Using a mouse model of the disease, researchers found that ten minutes of daily str…
inflammationfibrosisSystemic sclerosisStretchingscleroderma - A+2017
Effects of the menstrual cycle on lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament injury risk: a systematic review
Vivek Balachandar, Jan-Luigi Marciniak, Owen Wall, Chandrika BalachandarThis systematic review evaluated how the menstrual cycle affects lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament (ACL) injury risk in women. The authors found strong evidence that the risk…
Biomechanicsligamentneuromuscularcruciatemenstrual. - A++2016
Can fascia’s characteristics be influenced by manual therapy
Serge GracovetskyThis theoretical essay investigates the fundamental properties of collagen, a key component of fascia. The author explores how manual therapy might relate to the necessity of maintaining collagen's strength under load.…
Collagen; Models; MMP; Water - A2016
Hyaluronan production and molecular weight is enhanced in pathway-engineered strains of lactate dehydrogenase-deficient Lactococcus lactis
Mandeep Kaur, Guhan JayaramanResearchers are exploring ways to use engineered bacteria to produce hyaluronic acid (HA), but the yield and molecular weight have often been limited. Previous work suggested that excessive lactate production might be t…
Hyaluronic acid molecular weightLactococcus lactisLactate dehydrogenase mutantNADþ/NADH ratioHA-precursor concentration ratio - 1A+2016
Hormone receptor expression in human fascial tissue
Caterina Fede, G Albertin, L Petrelli, M M Sfriso, C Biz, R De Caro, Carla SteccoAdult women tend to experience more myofascial pain than men, and this study explored a possible hormonal link. Researchers examined fascial tissue from eight female volunteers, looking for receptors for the hormones es…
Fascia; fascial fibroblasts; estrogen; relaxin; immunostaining - C2016
Coordinated integrin activation by actin-dependent force during T-cell migration
P Nordenfelt, H L Elliott, T A SpringerResearchers investigated how immune cells, specifically T-cells, generate the force needed to move. Using fluorescent tension sensors, they visualized the tension within integrins, which are proteins that help cells gri…
cytoskeletonIntegrinsactin - A2016
Remote effects of lower limb stretching: preliminary evidence for myofascial connectivity?
Jan Wilke, Daniel Niederer, Lutz Vogt, Winfried BanzerThis study investigated whether stretching the lower body could affect neck mobility. Twenty-six healthy participants were divided into two groups, with one group performing static stretches for the calf and hamstring m…
Myofascial chains; force transmission; fascia; meridians - C2016
Protein—glycosaminoglycan interaction networks: Focus on heparan sulfate
Sylvie Ricard-BlumThis research overview describes a project focused on glycosaminoglycans (GAGs), complex sugars found on the cell surface and in the extracellular matrix. Specifically, it investigates heparan sulfate and how it interac…
extracellular matrixHeparan sulfateInteraction networksInteraction databasesSurface plasmon resonance - A+2016
Health E!ects of Alkaline Diet and Water, Reduction of Digestive-tract Bacterial Load, and Earthing
Haider Abdul-Lateef MousaThis narrative review discusses how an alkaline diet, alkaline water, reduced digestive-tract bacterial load, and “earthing” might counter chronic low-grade acidosis. The author synthesizes literature suggesting these a…
chronic inflammationearthinghypertensionMetabolic acidosisalkaline diet - A2016
Patterns of attachment of the myodural bridge by the rectus capitis posterior minor muscle
Xiao-Ying Yuan, Sheng-Bo Yu, Yun-Fei Li, Yan-Yan Chi, Nan Zheng, Hai-Bin Gao, Bing-Yi Luan, Zhao-Xi Zhang, Hong-Jin SuiThis anatomical study used dissection and plastination techniques to examine the myodural bridge, a small tissue connection in the upper neck. Researchers focused on the attachments of the rectus capitis posterior minor…
Myodural Bridgerectus capitis posterior minor muscleChronic cervicogenic headacheCirculation of cerebrospinal fluidPlastination technology - A+++2016
Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation
William R Thompson, Alexander Scott, M Terry Loghmani, Samuel R Ward, Stuart J WardenThis perspective article explores the field of mechanobiology and how physical therapists use mechanical forces to promote tissue healing. It explains that cells in our muscles, bones, and tendons respond to physical st…
RehabilitationTherapymechantransduction - A++2016
Three Case Reports of Successful Vibration Therapy of the Plantar Fascia for Spasticity Due to Cerebral Palsy-Like Syndrome, Fetal-Type Minamata Disease
Fusako Usuki, Satsuki TohyamaThis series of case reports describes the long-term effects of vibration therapy on lower-limb spasticity in three patients with fetal-type Minamata disease, a condition with symptoms similar to cerebral palsy. Research…
spasticityvibration therapyFDM - A2016
What Is Evidence-Based About Myofascial Chains: A Systematic Review
Jan Wilke, Frieder Krause, Lutz Vogt, Winfried BanzerThis systematic review evaluated anatomical dissection studies to find evidence for six proposed myofascial meridians. Researchers analyzed 62 studies and found strong evidence for the anatomical continuity of three lin…
fasciaForce transmissionmyofascial chainsmeridians - A2016
Acute bouts of upper and lower body static and dynamic stretching increase non‑local joint range of motion
David George Behm, Tyler Cavanaugh, Patrick Quigley, Jonathan Christopher Reid, Priscyla Silva Monteiro Nardi, Paulo He…This study investigated whether stretching one part of the body could increase flexibility in a completely different area. Researchers had participants perform either static or dynamic stretches for their shoulders and,…
Crossover fatigue · Non-local muscle fatigue · Flexibility · Range of motion · Strength · Electromyography - A2016
Intermuscular force transmission along myofascial chains: a systematic review
Frieder Krause, Jan Wilke, Lutz Vogt, Winfried BanzerThis systematic review examined evidence for force transmission along continuous lines of muscle and fascia, often called myofascial chains. Researchers analyzed nine studies of moderate to excellent quality that invest…
anatomy trains; fascia; myofascial continuity; tension transfer - A2016
Is remote stretching based on myofascial chains as effective as local exercise? A randomised-controlled trial
Jan Wilke, L Vogt, D Niederer, W BanzerThis randomized controlled trial investigated whether stretching the lower limbs could improve neck mobility as effectively as direct neck stretching. Researchers divided 63 healthy participants into three groups: one s…
Myofascial chains; force transmission; fascia; meridians; MiSpEx - A2016
Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase
Sebastian Kalamajski, Dominique Bihan, Arkadiusz Bonna, Kristofer Rubin, Richard W FarndaleFibrosis is characterized by a dense and stiff collagen matrix, formed through a cross-linking process driven by the enzyme lysyl oxidase (LOX). This study investigated the role of another protein, fibromodulin, in this…
fibrosiscollagen cross-linkingfibromodulinlysyl oxidase - A+++2016
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms
In Young Choi, Laura Piccio, Patra Childress, Bryan Bollman, Arko Ghosh, Sebastian Brandhorst, Jorge Suarez, Andreas Mi…This study investigates how a periodic fasting-mimicking diet (FMD) affects symptoms of multiple sclerosis (MS) using mouse models and preliminary human trials. In animal models, the diet reduced inflammation and promot…
Fasting-mimicking diet; Intermittent fasting; Time-restricted eating; autoimmunity; multiple sclerosis - A+++2016
Fascial Manipulation® for chronic aspecific low back pain: a single blinded randomized controlledtrial.
Mirco Branchini, Francesca Lopopolo, Ernesto Andreoli, Ivano Loreti, Aurélie M Marchand, Antonio SteccoThis randomized controlled trial compared Fascial Manipulation® combined with standard physiotherapy to physiotherapy alone for patients with chronic non-specific low back pain. The group receiving Fascial Manipulation®…
hyaluronanBack PainFascial manipulation