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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 301–360 of 427 studies · page 6/8A
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  1. A
    2012

    Real-time imaging of cortical areas involved in the generation of increases in skin sympathetic nerve activity when viewing emotionally charged images

    Luke A Henderson, Alexandra Stathis, Cheree James, Rachael Brown, Skye McDonald, Vaughan G Macefield

    This study investigated which brain regions are involved when our bodies react to emotional images. Researchers simultaneously measured brain activity with fMRI and skin sympathetic nerve activity (SSNA), a marker of th…

    fasciaMRIIASP imagesmicroneurographyskin sympathetic nerve activity
  2. A
    2012

    Primo Vascular System as a New Morphofunctional Integrated System

    Miroslav Stefanov, Jungdae Kim

    This narrative review summarizes research on the primo vascular system (PVS), a proposed anatomical network found throughout the body. The authors describe the methods and instruments used to study this system, primaril…

    fasciacancerphysiologyMorphologyprimo vascular system
  3. A
    2012

    Earthing: Health Implications of Reconnecting the Human Body to the Earth’s Surface Electrons

    Gaétan Chevalier, Stephen T Sinatra, James L Oschman, Karol Sokal, Pawel Sokal

    This 2012 review paper explores the concept of 'earthing' or 'grounding,' which involves direct physical contact with the Earth's surface electrons. The authors propose that modern lifestyles separate humans from this c…

    fasciaearthinggroundingearth surface electrons
  4. A
    2012

    Myoton Pro: A Novel Tool for the Assessment of Mechanical Properties of Fascial Tissues

    Aleko Peipsi, Ricardas Kerpe, Heike Jäger, Sonja Soeder, Christopher Gordon, Robert Schleip

    This research entry, for which only the title is available, appears to introduce a device called the MyotonPRO. The title suggests its purpose is to assess the mechanical properties of fascial tissues, such as their sti…

    fasciaMyotone Pro
  5. A
    2011

    Management of the stiff shoulder. A prospective multicenter comparative study of the six main techniques in use: 235 cases

    P Gleyzea, P Clavert, P-H Flurin, E Laprelle, D Katz, B Toussaint, T Benkalfate, C Charousset, T Joudet, T Georges, L H…

    This prospective study compared six different therapeutic techniques for stiff shoulder in 235 patients. Researchers evaluated conventional rehabilitation below the pain threshold against self-rehabilitation pushing pas…

    frozen shoulderAdhesive capsulitisPain managementAlgodystrophyTherapeutic education
  6. A
    2011

    The extracellular matrix: an active or passive player in fibrosis?

    T N Wight, S Potter-Perigo

    Fibrosis, the excessive buildup of scar tissue, can be understood as a wound healing process that has gone awry. Normally, specialized cells called myofibroblasts help repair tissue and then disappear, but in fibrosis,…

    fasciaprovisional extracellular matrixmyofibroblatcollagenhyaluronan proteoglycans
  7. A
    2011

    The Genetics of Vitamin C Loss in Vertebrates

    Guy Drouin, Jean-Rémi Godin, Benoît Pagé

    This narrative review explores why some vertebrate species, including humans, cannot produce their own Vitamin C. The inability to synthesize this crucial nutrient, important for collagen and antioxidant functions, stem…

    BiosynthesisVitamin CAscorbic acidGLO geneL-gulono-gamma-lactone oxidase
  8. A
    2011

    Correlation of MR Arthrographic Findings and Range of Shoulder Motions in Patients With Frozen Shoulder

    So-Yeon Lee, Jeongmi Park, Seok-Whan Song

    This study investigated the relationship between findings on MR arthrography (a type of MRI) and range of motion in people with frozen shoulder. Researchers measured the thickness of two structures: the coracohumeral li…

    MRIfrozen shoulderAdhesive capsulitiscoracohumeral ligament
  9. A
    2011

    Sensory Innervation of the Nonspecialized Connective Tissues in the Low Back of the Rat

    Sarah M Corey, Margaret A Vizzard, Gary J Badger, Helene M Langevin

    In this animal study, researchers investigated the sensory nerves in the nonspecialized connective tissue of the rat low back, an area where knowledge is limited. Using 3D reconstruction and dye-labeling techniques, the…

    fasciaConnective tissueinnervationlow back painmusculoskeletal pain
  10. A
    2011

    Fascia and the mechanism of acupuncture

    Steven Finando, Donna Finando

    This theoretical paper re-evaluates the mechanisms of acupuncture. The authors propose that fascia, the body's connective tissue network, is the structure that explains how acupuncture works. They argue for this model b…

    fasciaacupunctureShamPlaceboMechanism
  11. A
    2011

    Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis

    Carol A de la Motte

    This narrative review explores the role of hyaluronan (HA) in intestinal health and disease. Chronic intestinal inflammation can lead to fibrosis, or scarring, a process driven by inflammatory signals and specialized ce…

    hafasciaextracellular matrixfibrosismesenchymal cells
  12. A
    2011

    Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

    Thomas R Cox, Janine T Erler

    In this perspective article, the authors discuss how the extracellular matrix (ECM) is constantly being remodeled, a process essential for normal bodily functions like wound healing and tissue maintenance. When this rem…

    fasciaextracellular matrixcancerfibrosisstiffness
  13. A
    2011

    Fibroblast cytoskeletal remodeling contributes to connective tissue tension

    H M Langevin, N A Bouffard, J R Fox, B M Palmer, J Wu, J C Iatridis, W D Barnes, G J Badger, A K Howe

    The mechanical properties of connective tissue, such as its elasticity and resistance, have traditionally been attributed to its non-cellular matrix. This study investigated the role of fibroblasts, the cells residing w…

    fasciaConnective tissuefibroblastcytoskeletal remodeling
  14. A
    2011

    A questionnaire survey of UK physiotherapists on the diagnosis and management of contracted (frozen) shoulder

    Nigel C A Hanchard, Lorna Goodchild, Jackie Thompson, Tracey O’Brien, Dot Davison, Chris Richardson

    This survey of 289 UK physiotherapists explored how they diagnose and manage frozen shoulder. The results showed that diagnosis typically relies on assessing movement restriction, particularly passive external rotation.…

    frozen shoulderAdhesive capsulitisShoulder painDiagnosisTherapy
  15. A
    2011

    Sensory Innervation of the Thoracolumbar Fascia in Rats and Humans

    J Tesarz, U Hoheisel, B Wiedenhöfer, S Mense

    This study investigated the nerve supply of the thoracolumbar fascia (TLF), the connective tissue of the low back, in both rats and humans. Researchers found that the fascia is richly innervated with sensory nerves, but…

    fasciaNociceptionThoracolumbar fascialow back painimmunohistochemistry
  16. A
    2011

    Anatomical Connection Between the Rectus Capitis Posterior Major and the Dura Mater

    Frank Scali, Eric S Marsili, Matthew E Pontell

    In this anatomical study, researchers dissected 13 cadavers to investigate a connection between a deep neck muscle and the dura mater, the protective covering of the spinal cord. In 11 of the 13 specimens, they found a…

    fasciacervical spineposterior atlantoaxial interspacerectus capitis posterior majorspinal dura
  17. A
    2011

    Pandiculation: Nature’s way of maintaining the functional integrity of the myofascial system?

    Luiz Fernando Bertolucci

    This paper explores the hypothesis that pandiculation—the involuntary stretching and yawning most animals do upon waking—serves a key role for the locomotor system. Beyond preparing the nervous system for wakefulness, t…

    fasciaConnective tissuemyofasciayawningsleep-wake rhythm
  18. A
    2011

    Assessing the influence of FDM to the postoperative healing processes in distal fracture of the radius

    Tomasz Teszner

    Researchers investigated if the Fascial Distortion Model (FDM) could improve recovery following surgery for a common wrist fracture. In this study, 65 patients were divided into two groups; one received standard rehabil…

    fasciaManual Therapyfasciaefascial distortion modelreductionism
  19. A
    2011

    Correlations Between Fasciology and Yin Yang Doctrine

    Hui Tao, Mei-Chun Yu, Hui-Ying Yang, Rong-Mei Qu, Chun Yang, Xin Zhou, Yu Bai, Jing-Peng Wu, Jun Wang, Ou Sha, Lin Yuan

    This theoretical paper explores correlations between "fasciology," a model based on 3D reconstruction of connective tissue, and the traditional Chinese doctrine of yin and yang. According to fasciology, the body can be…

    fasciafasciologyfascial anatomytwo-system theoryyin yang doctrine
  20. A
    2011

    Elevated [11C]-D-Deprenyl Uptake in Chronic Whiplash Associated Disorder Suggests Persistent Musculoskeletal Inflammation

    Clas Linnman, Lieuwe Appel, Mats Fredrikson, Torsten Gordh, Anne Söderlund, Bengt Långström, Henry Engler

    Diagnosing chronic whiplash-associated disorder (WAD) is often difficult, as standard structural imaging methods seldom show clear signs of injury. This study used Positron Emission Tomography (PET) with a tracer molecu…

    inflammationfasciaWhiplash
  21. A
    2011

    Hyaluronan as an Immune Regulator in Human Diseases

    Paul W Noble, Jiurong Liang, Dianhua Jiang

    This 2011 narrative review explores the role of hyaluronan (HA) in the immune system. While intact HA is a normal part of the extracellular matrix, fragments of HA produced during tissue injury can act as signals. These…

    hyaluronanfascia
  22. A
    2011

    Dynamic fascial release and the role of mechanical/vibrational assist devices in manual therapies

    Zachary Comeaux

    This review article explores the use of mechanical vibration devices in manual therapy. The author examines several such tools, including percussion vibrators, vibrational platforms, and deep tissue oscillation. The art…

    fasciaConnective tissuevibrationpercussion vibrationtonic vibratory reflex
  23. A
    2011

    Exercise training reduces fibrosis and matrix metalloproteinase dysregulation in the aging rat heart

    Hyo-Bum Kwak, Jong-hee Kim, Kumar Joshi, Alvin Yeh, Daniel A Martinez, John M Lawler

    In this animal study, researchers investigated how exercise affects age-related fibrosis (scarring) in the rat heart. They found that aging was associated with an increase in collagen and a dysregulation of enzymes call…

    collagenRemodelingTIMP-1
  24. A
    2011

    Hyaluronan: From Extracellular Glue to Pericellular Cue

    B P Toole

    Hyaluronan is traditionally seen as a biological 'goo' that lubricates joints and holds connective tissues together. This review describes how hyaluronan also functions as an important signaling molecule, or cue, in the…

    hyaluronanfasciasignal transductioncancer
  25. A
    2011

    High and Low Molecular Weight Hyaluronic Acid Differentially Regulate Human Fibrocyte Differentiation

    A S Maharjan, D Pilling, R H Gomer

    Following tissue injury, immune cells called monocytes can differentiate into fibrocytes, a cell type involved in healing and fibrosis. This study investigated how different sizes of hyaluronic acid (HA) affect this pro…

    hyaluronanfasciafibrocyte differentiationmonocyte
  26. A
    2011

    Chronic Disease: Are We Missing Something?

    James L Oschman

    This 2011 editorial by James L. Oschman poses a question in its title: "Chronic Disease: Are We Missing Something?". Without an abstract or full text available for summary, the specific perspective or argument presented…

    fasciachronic diseaseearthing
  27. A
    2011

    ExtracellularMatrix Degradation and Remodeling in Development and Disease

    Pengfei Lu, Ken Takai, Valerie M Weaver, Zena Werb

    In this review, the authors describe the extracellular matrix (ECM) as a dynamic structure that is constantly being remodeled. This process of breakdown and rebuilding is essential for normal bodily functions like tissu…

    fasciaextracellular matrixmatrix remodeling
  28. A
    2011

    Structure and function of the skeletal muscle extracellular matrix

    Allison R Gillies, Richard L Lieber

    This narrative review explores the extracellular matrix (ECM), the connective tissue network within skeletal muscle. The authors describe the ECM's crucial roles in transmitting force and in muscle maintenance and repai…

    Skeletal muscle; extracellular matrix; collagen; biomechanics; fibrosis
  29. A
    2011

    Fibroblasts and Myofibroblasts: What are we talking about?

    Jennifer Baum, Heather S Duffy

    This 2011 narrative review explores the roles of fibroblasts and myofibroblasts, two key cell types in the heart's connective tissue. Once considered static, research indicates these cells are dynamic and play an active…

    fasciafibroblastMyofibroblast
  30. A
    2010

    Fluorescent Nanoparticles for Observing Primo Vascular System Along Sciatic Nerve

    Zhao-Feng Jia, Byung-Cheon Lee, Ki-Hoon Eom, Jin-Myung Cha, Jin-Kyu Lee, Zhen-Dong Su, Wen-Hui Yu, Pan Dong Ryu, Kwang-…

    In this animal study, researchers injected fluorescent nanoparticles into rats at an acupuncture point to trace their path. The particles traveled along the sciatic nerve, revealing a previously hard-to-detect structure…

    fasciaacupunctureSCIATIC NERVEprimo vascular systemprimo-vessel
  31. A
    2010

    Comparison of Trunk Proprioception Between Patients With Low Back Pain and Healthy Controls

    Angela S Lee, Jacek Cholewicki, Peter Reeves, Bohdanna T Zazulak, Lawrence W Mysliwiec

    In this case-control study, researchers compared trunk proprioception, or the sense of body position and movement, between 24 patients with non-specific low back pain and 24 healthy controls. Participants' ability to se…

    Kinesthesis; Low back pain; Proprioception; Rehabilitation; Spine
  32. A
    2010

    Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix

    Rolf K Reed, Kristofer Rubin

    This narrative review discusses how the extracellular matrix (ECM) and the pressure of its fluid (interstitial fluid pressure, or Pif) regulate fluid exchange with capillaries. Conventionally, this pressure is seen as a…

    inflammationConnective tissueglycosaminoglycansbeta-Integrin receptors
  33. A
    2010

    Role of Matrix-Rhythm-Therapy in the treatment of non-traumatic restricted movements of shoulder

    Sandeep Bhagwat

    This study investigated the effectiveness of Matrix-Rhythm-Therapy (MRT) for treating shoulder pain and stiffness not caused by injury. Forty patients received one hour of MRT weekly for three weeks, combined with daily…

    CyberneticsNonlinear ThermodynamicsMatrix-Rhythm-Therapy (MaRhyThe®)vibrations
  34. A
    2010

    Possible Applications for Fascial Anatomy and Fasciaology in Traditional Chinese Medicine

    Yu Bai, Lin Yuan, Kwang-Sup Soh, Byung-Cheon Lee, Yong Huang, Chun-lei Wang, Jun Wang, Jin-peng Wu, Jing-xing Dai, Jano…

    This theoretical paper proposes a new framework for understanding anatomy, called "fascial anatomy," and a new field of study, "fasciaology." The authors suggest that the body's fascial network may be the anatomical bas…

    fasciameridiansacupointsprimo-vesseltraditional Chinese medicine
  35. A
    2010

    The role and mechanical behavior of the connective tissue in tendon sliding

    J-C Guimberteau, J-P Delage, J Wong

    Based on 215 in-vivo dissections, this study challenges the traditional understanding of how tendons slide. The authors propose that tendon movement is not simple gliding, but rather occurs within a complex, adaptable c…

    Tendon; Carpal sheath; Sliding system; Tendon vascularization; Finger flexor reconstruction; Collagenic fibrillar framework; Microvacuole
  36. A
    2010

    3D reconstruction of the crural and thoracolumbar fasciae

    L Benetazzo, A Bizzego, R De Caro, G Frigo, D Guidolin, Carla Stecco

    Researchers created detailed 3D computer models to visualize the structure of the crural fascia in the lower leg and the superficial layer of the thoracolumbar fascia in the lower back. They found the crural fascia is c…

    Connective tissuecollagenThoracolumbar fasciacrural fascia3D models
  37. A
    2010

    Spontaneous and visible light-induced ultraweak photon emission from rat eyes

    Chao Wanga, István Bókkonb, Jiapei Daia, István Antalc

    In this in vitro study on rats, researchers found that isolated parts of the eye—the whole eye, lens, vitreous humor, and retina—emit extremely faint light, or photons. This photon emission occurred both spontaneously a…

    fasciabioluminescent photonslipid peroxidationdiscrete dark noiseretinal phosphenes
  38. A
    2010

    How much time is required to modify a fascial fibrosis?

    Ercole Borgini, Antonio Stecco, Julie Ann Day, Carla Stecco

    This study investigated how long it takes for manual therapy to alter a palpable sensation of fascial "fibrosis" and reduce discomfort. Researchers worked with 40 people experiencing low back pain, applying the Fascial…

    fasciaConnective tissueManual Therapylow back painManipulation
  39. A
    2010

    Collagens

    Marion K Gordon, Rita A Hahn

    This 2010 review describes the collagen family, a group of proteins that form the structural framework of the body's tissues. Each collagen molecule consists of three chains twisted into a triple helix, a shape that giv…

    Collagens; Extracellular matrix; Fibrils; FACITs; Basement membrane
  40. A
    2010

    Edema and fluid dynamics in connective tissue remodelling

    Rolf K Reed, Åsa Lidén, Kristofer Rubin

    This review describes the role of loose connective tissues, focusing on fluid exchange across capillaries and the formation of edema (swelling). This process is relevant for conditions like inflammation, fibrosis (scarr…

    inflammationLoose connective tissueConnective tissueheartEdema
  41. A
    2009

    Communicating About Fascia: History, Pitfalls, and Recommendations

    Helene M Langevin, Peter A Huijing

    In this commentary, the authors discuss how the word "fascia" can be ambiguous and lead to misunderstandings, as it can refer to anything from loose to dense connective tissue. This lack of precision can hinder communic…

    fasciaConnective tissueSubcutaneous tissueterminologyaponeurosis
  42. A
    2009

    Fascia: A missing link in our understanding of the pathology of fibromyalgia

    Ginevra L Liptan

    This 2009 paper proposes that inflammation in the fascia, the body's connective tissue, could be a key source of the persistent pain signals that lead to central sensitization in fibromyalgia. While muscle tissue itself…

    inflammationfasciaConnective tissueMyofascial releaseManual Therapy
  43. A
    2009

    The treatment of Chronic Low Back Pain following the principles of the Fascial Distortion Modell (FDM)

    Rainer Engel

    This small study investigated the effect of two Fascial Distortion Model (FDM) treatments on 22 people with chronic low back pain. Researchers measured pain, function, flexibility (finger-floor distance), and use of pai…

    Manual Therapyfasciaefascial distortion modelreductionismtypaldos
  44. A
    2009

    Mechanotherapy: how physical therapists’ prescription of exercise promotes tissue repair

    K M Khan, A Scott

    This review article explains the concept of "mechanotherapy," which is the use of prescribed exercise to promote tissue repair. The underlying biological process is called mechanotransduction, where the body's cells sen…

    fasciamechanotherapyechanotransduction
  45. A
    2009

    Effect of Loading on the Organization of the Collagen Fibril Network in Juvenile Equine Articular Cartilage

    Pieter A J Brama, Jaakko Holopainen, P René van Weeren, Elwyn C Firth, Heikki J Helminen, Mika M Hyttinen

    In this animal study, researchers investigated how exercise-induced loading affects the collagen network in the articular cartilage of juvenile horses. They compared two sites within a joint: one subjected to high-inten…

    cartilage; collagen fibril; loading; parallelism; orientation
  46. A
    2009

    Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

    Ning Wang, Jessica D Tytell, Donald E Ingber

    In this narrative review, the authors explore how mechanical forces can influence the cell nucleus from a distance. Research has often focused on how external forces are converted into chemical signals at the cell's sur…

    fasciaextracellular matrixcytoskeletonmechanotransductioncell nucleus
  47. A
    2009

    The Hard Life of Soft Cells

    P A Janmey, J P Winer, M E Murray, Q Wen

    This brief review explores how cells function as both mechanical and chemical machines. Cells constantly generate and respond to physical forces within their environment, the extracellular matrix. The stiffness of this…

    fasciamechanotransductionsubstrate stiffnesscell mechanics
  48. A
    2009

    The Architecture of the Connective Tissue in the Musculoskeletal System—An Often Overlooked Functional Parameter as to Proprioception in the Locomotor Apparatus

    Jaap van der Wal

    This article proposes that the traditional anatomical view, which separates muscles from "passive" connective tissues like ligaments, is incomplete. The author argues that muscle and connective tissue function together…

    fasciaConnective tissueproprioceptionskeletal muscledissection
  49. A
    2009

    Ascorbate and plasma membrane electron transport—Enzymes vs ef!ux

    Darius J R Lane, Alfons Lawen

    Cells have systems to move electrons across their outer membrane, a process which uses substances like ascorbate (Vitamin C) from inside the cell. Traditionally, this was thought to happen via enzymes that shuttle elect…

    Ascorbate Astrocytes Dehydroascorbate Ferricyanide K562 cells Non-transferrin-bound iron Transplasma membrane electron transport Vitamin C
  50. A
    2009

    Relevance of Collagen Piezoelectricity to “Wolff’s Law”: a Critical Review

    Andrew C Ahn, Alan J Grodzinsky

    This narrative review explores how bone adapts to mechanical stress, a principle known as Wolff's Law. For decades, scientists have investigated how bone cells sense this stress to trigger remodeling. An early theory pr…

    fasciacollagenpiezoelectricwolff's law
  51. A
    2009

    Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain

    Helene M Langevin, Debbie Stevens-Tuttle, James R Fox, Gary J Badger, Nicole A Bouffard, Martin H Krag, Junru Wu, Sharo…

    Researchers investigated whether structural differences exist in the low back's connective tissues between people with and without chronic low back pain. Using ultrasound, they measured the thickness and echogenicity (h…

    fasciaConnective tissuelow back painlumbar
  52. A
    2009

    From mechanotransduction to extracellular matrix gene expression in fibroblasts

    Matthias Chiquet, Laurent Gelman, Roman Lutz, Silke Maier

    This 2009 review article explores how connective tissue cells, or fibroblasts, sense and respond to mechanical forces from their environment. Cells attach to the surrounding extracellular matrix via adhesion contacts, w…

    fasciaextracellular matrixfibroblastcytoskeletonmechanotransduction
  53. A
    2008

    Fibronectin Unfolding Revisited: Modeling Cell Traction- Mediated Unfolding of the Tenth Type-III Repeat

    Elaine P S Gee, Donald E Ingber, Collin M Stultz

    Cells build the extracellular matrix by pulling on the protein fibronectin, causing it to assemble into fibrils. This study used computer simulations to investigate how this process works at a molecular level. Researche…

    fasciaFibronectincell tractionintegrinfibrillogenesis
  54. A
    2008

    Dorsal horn neurons having input from low back structures in rats

    T Taguchi, U Hoheisel, S Mense

    In this animal study, researchers in rats investigated how spinal cord nerve cells (dorsal horn neurons) process signals from the low back. They found that these neurons often receive input from several different tissue…

    fascialow back painmultifidus muscledorsal horn neuronsnerve growth factor (NGF)
  55. A
    2008

    Differential effects of hyaluronan and its fragments on fibroblasts: Relation to wound healing

    Maha David-Raoudi, Frederic Tranchepain, Brigitte Deschrevel, Jean-Claude Vincent, Patrick Bogdanowicz, Karim Boumedien…

    This lab study investigated how hyaluronan (HA) of different molecular sizes affects human fibroblast cells, which are key to wound healing. Researchers exposed fibroblasts to native HA and two smaller fragments. All th…

    hyaluronanfasciawound healingextracellular matrixfibrosis
  56. A
    2008

    Magnetic Resonance Imaging of Adhesive Capsulitis: Correlation with Clinical Staging

    Carolyn M Sofka, Gina A Ciavarra, Jo A Hannafin, Frank A Cordasco, Hollis G Potter

    This study investigated whether standard magnetic resonance imaging (MRI) can be used to diagnose and stage adhesive capsulitis (frozen shoulder). Researchers retrospectively reviewed MRI scans from 46 patients with an…

    Adhesive capsulitisShoulderMagnetic resonance imaging
  57. A
    2008

    Mechanotransduction – a field pulling together?

    Christopher S Chen

    In this 2008 review article, the author discusses mechanotransduction, the process by which cells convert mechanical forces into biochemical signals. Cells are constantly subjected to forces, both from external pressure…

    fasciastiffnessmechanobiologycell adhesionmechanical force
  58. A
    2008

    Tensegrity-Based Mechanosensing from Macro to Micro

    Donald E Ingber

    This review article, based on a lecture, explores how cells convert mechanical signals into biochemical responses. The author proposes that the body uses "tensegrity" (tensional integrity) principles, where interconnect…

    fasciaextracellular matrixTensegritycytoskeletonmechanotransduction
  59. A
    2008

    Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

    Karl E Kadler, Adele Hill, Elizabeth G Canty-Laird

    This 2008 review article explores how collagen fibrils, the main structural components of connective tissue, are formed. While collagen can self-assemble in a test tube, the process in living tissues is carefully manage…

    fasciaIntegrinsFibronectincollagen fibrillogenesis
  60. A
    2008

    Anti-angiogenic effect of high doses of ascorbic acid

    Nina A Mikirova, Thomas E Ichim, Neil H Riordan

    This laboratory study investigated how high doses of ascorbic acid (vitamin C) affect the formation of new blood vessels, a process called angiogenesis. Researchers exposed several types of human endothelial cells, incl…

    AngiogenesisVitamin CAscorbic acid