Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Functional organization of extracellular hyaluronan, CD44 and RHAMM
In this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…
Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory
This narrative review explores hyaluronic acid (HA), a naturally occurring substance found in connective tissues and synovial fluid. HA is essential for joint lubrication and viscoelasticity, but its concentration and m…
Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
This narrative review summarizes current knowledge about hyaluronan, a molecule whose biological effects are dependent on its size. Unlike many other molecules, hyaluronan's signaling properties are determined not by ch…
Ingested hyaluronan moisturizes dry skin
This review article summarizes research on how oral hyaluronan (HA) supplements may influence skin hydration levels. Studies suggest that a daily intake of 120–240 mg of hyaluronic acid can contribute to increased moist…
Mathematical Analysis of the Flow of Hyaluronic Acid Around Fascia During Manual Therapy Motions
This study used a mathematical model to simulate how different manual therapy techniques affect the flow of hyaluronic acid (HA) within fascia. The researchers compared constant sliding, perpendicular vibration, and tan…
Structural Behavior of Highly Concentrated Hyaluronan
Researchers investigated the behavior of highly concentrated hyaluronan (HA) in a physiological saline solution. They found that HA molecules can organize into stable, larger "superstructures." When heated, the fluid's…