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The Fascia Guide

Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–6 of 6 studieshyaluronanA++With summary
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  1. A++
    2023

    Functional organization of extracellular hyaluronan, CD44 and RHAMM

    Mary K Cowman, Eva A Turley

    In this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…

    hyaluronanCD44extracellular matrixRHAMMpericellular matrix
  2. A++
    2019

    Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory

    Ramesh C Gupta, Rajiv Lall, Ajay Srivastava, Anita Sinha

    This narrative review explores hyaluronic acid (HA), a naturally occurring substance found in connective tissues and synovial fluid. HA is essential for joint lubrication and viscoelasticity, but its concentration and m…

    hyaluronanwound healingHyaluronic acidosteoarthritiscancer therapy
  3. A++
    2015

    Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

    Jaime M Cyphert, Carol S Trempus, Stavros Garantziotis

    This narrative review summarizes current knowledge about hyaluronan, a molecule whose biological effects are dependent on its size. Unlike many other molecules, hyaluronan's signaling properties are determined not by ch…

    hyaluronanCell signalingmolecular size
  4. A++
    2014

    Ingested hyaluronan moisturizes dry skin

    Chinatsu Kawada, Takushi Yoshida, Hideto Yoshida, Ryosuke Matsuoka, Wakako Sakamoto, Wataru Odanaka, Toshihide Sato, Ta…

    This review article summarizes research on how oral hyaluronan (HA) supplements may influence skin hydration levels. Studies suggest that a daily intake of 120–240 mg of hyaluronic acid can contribute to increased moist…

    hyaluronanhaHyaluronic acidSkinsupplementation
  5. A++
    2013

    Mathematical Analysis of the Flow of Hyaluronic Acid Around Fascia During Manual Therapy Motions

    Max Roman, Hans Chaudhry, Bruce Bukiet, Antonio Stecco,Thomas Findley

    This study used a mathematical model to simulate how different manual therapy techniques affect the flow of hyaluronic acid (HA) within fascia. The researchers compared constant sliding, perpendicular vibration, and tan…

    hyaluronanfasciaManual Therapyfluid flowvibration
  6. A++
    2009

    Structural Behavior of Highly Concentrated Hyaluronan

    Paolo Matteini, Luigi Dei, Emiliano Carretti, Nicola Volpi, Andrea Goti, Roberto Pini

    Researchers investigated the behavior of highly concentrated hyaluronan (HA) in a physiological saline solution. They found that HA molecules can organize into stable, larger "superstructures." When heated, the fluid's…

    hyaluronanHA structure