Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A+++2021
Fascial thickness and stiffness in hypermobile Ehlers-Danlos syndrome
Tina J Wang, Antonio SteccoResearchers investigated fascial changes in people with hypermobile Ehlers-Danlos Syndrome (hEDS), a condition often associated with widespread pain. They used ultrasound and elastography to compare fascial thickness an…
deep fasciaconnective tissue disorderhypermobile Ehlers-Danlos syndromeultrasound elastography - A+++2021
The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self
Wen G Chen, Dana Schloesser, Angela M Arensdorf, Janine M Simmons, Changhai Cui, Rita Valentino, James W Gnadt, Lisbeth…This review article presents a unified framework for interoception, the process by which the body senses, interprets, and regulates its internal signals. The authors propose an expanded definition that includes bidirect…
autonomic; insula; parasympathetic; spinal; sympathetic; vagal - A+++2021
An acupoint-originated human interstitial fluid circulatory network
HongYi Li, Fang Wang, Min Chen, Zhi-Jian Zheng, Ya-Jun Yin, Jun Hu, Hua Li, Andreas Sammer, Georg Feig, Norbert Maurer,…Details from this study have not yet been summarized. The study's title is "An acupoint-originated human interstitial fluid circulatory network". This title suggests the authors are proposing a circulatory network for i…
meridiansacupointsinterstitium - A+++2021
Variant connective tissue (joint hypermobility) and dysautonomia are associated with multimorbidity at the intersection between physical and psychological health
Jenny L L Csecs, Nicholas G Dowell, Georgia K Savage, Valeria Iodice, Christopher J Mathias, Hugo D Critchley, Jessica…This study investigated the links between joint hypermobility, autonomic nervous system dysfunction (dysautonomia), and anxiety in adults with mental health or neurodevelopmental conditions. Researchers found that this…
joint hypermobilityAnxietyautonomic dysfunctionmultimorbidity - A+++2021
Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression
Harriet Emma Clare Sharp, Hugo D Critchley, Jessica A EcclesThis narrative review explores the growing evidence linking joint hypermobility, a common connective tissue variant, with a range of psychiatric conditions. The authors summarize the well-established connection to anxie…
Hypermobile Ehlers-Danlos syndrome; Joint hypermobility; Mind-body relations; Neurodevelopmental disorders; Psychiatric disorders; Psychopathology. - A+++2021
Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism
Brian Tuckey, John Srbely, Grant Rigney, Meena Vythilingam, Jay ShahIn this theoretical paper, the authors propose a potential mechanism for chronic pain syndromes. They hypothesize that impaired lymphatic drainage following trauma or an immune response can trap inflammatory substances…
fasciacytokinesinterstitial inflammatory stasislymphatic dysfunctioncounterstrain techniques - A+++2021
Direct impact of commonly used dietary emulsifiers on human gut microbiota
Sabrine Naimi, Emilie Viennois, Andrew T Gewirtz, Benoit ChassaingThis laboratory study examined how 20 common dietary emulsifiers affect human gut microbiota using an ex vivo model. The researchers found that several additives, particularly carrageenans and various gums, altered bact…
Dietary emulsifier; Gut microbiota; IBD; Intestinal inflammation - A+++2021
Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome
Magdy El-Salhy, Jørgen Valeur, Trygve Hausken, Jan Gunnar HatlebakkThis clinical study investigated how fecal microbiota transplantation (FMT) affects short-chain fatty acids (SCFAs) in patients with irritable bowel syndrome (IBS). Researchers found that levels of butyric acid increase…
Fecal microbiota transplantationshort chain fatty acidsbutyric acidIrritable Bowel Syndrom - A+++2021
Cell-to-Cell Communication by Host-Released Extracellular Vesicles in the Gut: Implications in Health and Disease
Natalia Diaz-Garrido, Cecilia Cordero, Yenifer Olivo-Martinez, Josefa Badia, Laura BaldomàThis narrative review explores how small sacs called extracellular vesicles (EVs) act as messengers between cells in the gastrointestinal tract. These vesicles transport proteins, lipids, and genetic material that influ…
exosomes; extracellular vesicles; gut communication; gut immunity; intestinal homeostasis; miRNAs - A+++2021
A Closer Look at the Cellular and Molecular Components of the Deep/Muscular Fasciae
Caterina Fede, Carmelo Pirri, Chenglei Fan, Lucia Petrelli, Diego Guidolin, Raffaele De Caro, Carla SteccoThis narrative review describes fascia as a complex and dynamic connective tissue network. This network is composed of different cell types, an extracellular matrix, and nerve fibers. Each component plays a specific rol…
fascia; cells; extracellular matrix; nerve - A+++2021
Evidence of a new hidden neural network into deep fasciae
Caterina Fede, Lucia Petrelli, Diego Guidolin, Andrea Porzionato, Carmelo Pirri, Chenglei Fan, Raffaele De Caro, Carla…In this study on mice, researchers examined the nerve networks within two different types of deep fascia: the thoracolumbar fascia (in the lower back) and the gluteal fascia (around the buttock muscles). They found that…
deep fasciainnervation of fascia. low back pain - A+++2021
Fascia Mobility, Proprioception, and Myofascial Pain
Helene M LangevinThe body's fascial network is a crucial, yet often overlooked, component of the musculoskeletal system. Its ability to allow muscles and other tissues to slide past one another is essential for healthy movement and may…
fascia; interoception; proprioception; myofascial pain; connective tissue; fascia mobility - A+++2021
Hyaluronan and the Fascial Frontier
Rebecca L PrattThis narrative review explores the role of hyaluronan (HA) in the body's fascial system. HA is a key component of the extracellular matrix, widely used in products from skin creams to joint injections for its ability to…
HA; connective tissue; densification; extracellular matrix; fascia; fasciacyte; gliding; hyaluronan; hyaluronic acid; myofascial pain. - A+++2021
The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors
Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye ChenThis study investigated the effects of fecal microbiota transplantation (FMT) on patients with diarrhea-predominant IBS (IBS-D) who also experience anxiety and depression. The results suggest that FMT may alleviate both…
Anxiety and depression; Fecal microbiota transplantation; Irritable bowel syndrome; Metagenome; Short-chain fatty acids - A+++2021
Parameter-Dependency of Low-Intensity Vibration for Wound Healing in Diabetic Mice
Rita E Roberts, Onur Bilgen, Rhonda D Kineman, Timothy J KohIn this animal study on diabetic mice, researchers investigated how different settings of low-intensity vibration affect wound healing. The mice were exposed to various combinations of vibration frequency and accelerati…
wound healingAngiogenesisgrowth factorsdiabeteslow-intensity vibration - A+++2021
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
Giulia Salvadori, Federica Zanardi, Fabio Iannelli, Riccardo Lobefaro, Claudio Vernieri, Valter D LongoThis study investigates how a fasting-mimicking diet (FMD) affects triple-negative breast cancer and its stem cells. Researchers found that FMD lowers blood glucose and inhibits growth signaling in cancer stem cells, wh…
CDK4/6; PI3K/AKT; PKA; cancer stem cells; fasting; fasting-mimicking diet; glucose; mTOR; starvation escape pathways; triple-negative breast cancer - A+++2021
Reconnecting the Brain with the Rest of the Body in Musculoskeletal Pain Research
Helene M LangevinIn this commentary, the author argues that musculoskeletal pain research is often siloed into separate specialties like neuroscience, physical therapy, orthopedics, and rheumatology. This separation creates gaps in know…
Musculoskeletal pain; chronic pain; muscle; connective tissue; mind and body practices - A+++2021
Nutrition Provides the Essential Foundation for Optimizing Mental Health
Julia J Rucklidge, Jeanette M Johnstone, Bonnie J KaplanThis review article explores the critical link between nutrition and mental health, written to guide psychologists in their clinical practice. The authors outline how a whole-foods diet supports brain function through v…
Vitamins; minerals; nutrition; nutrients; treatment; mental health - A+++2021
Psychological and biological resilience modulates the effects of stress on epigenetic aging
Zachary M Harvanek, Nia Fogelman, Ke Xu, Rajita SinhaChronic stress is linked to negative health outcomes, and this study explored its connection to accelerated biological aging. Researchers evaluated 444 adults, measuring their cumulative stress, biological age using an…
AgingStresspsychological morbidityanxityepigenetic - A+++2021
Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype
Cristina Ferreira Almeida, Natércia Teixeira, Georgina Correia-da-Silva, Cristina AmaralThis narrative review explores how different subtypes of breast cancer respond to cannabinoids like THC and CBD. Research suggests that estrogen receptor-negative cells may be more susceptible to these compounds than ho…
Cannabis sativa; anandamide; breast cancer; cannabidiol; cannabidivarin; cannabigerol; cannabinoids; cannabinol; Δ9-tetrahydrocannabinol - A+++2020
Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C?
Anitra C CarrKnown only by its title, this article appears to be a commentary or analysis of a randomized controlled trial (RCT) known as VITAMINS. The title poses a question about whether there might be a "redundancy," or overlappi…
Vitamin Ccorticosteroidsstress respons - A+++2020
Vitamin C-An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Patrick Holford, Anitra C Carr, Thomas H Jovic, Stephen R Ali, Iain S Whitaker, Paul E Marik, A David SmithIn this literature review, the authors examine vitamin C as a potential adjunctive therapy for respiratory infections, sepsis, and COVID-19. They highlight the vitamin's antioxidant, anti-inflammatory, and immunomodulat…
COVID-19; SARS-CoV-2; coronavirus; vitamin C; ascorbate; colds; pneumonia; sepsis; immunonutrition; supplementation - A+++2020
Cannabis and cannabidiol (CBD) for the treatment of fibromyalgia
Amnon A Berger, Joseph Keefe, Ariel Winnick, Elasaf Gilbert, Jonathan P Eskander, Cyrus Yazdi, Alan D Kaye, Omar Viswan…This narrative review examines the use of cannabis and cannabidiol (CBD) for treating fibromyalgia, a complex condition that often responds poorly to standard therapies. The authors note that while high-quality randomiz…
CBT; SNRI; SSRI; chronic pain; depression; myalgia. - A+++2020
Overview of the possible role of vitamin C in management of COVID-19
Anis Abobaker, Aboubaker Alzwi, Alsalheen Hamed A AlraiedIn this 2020 review, the authors examine the possible role of vitamin C in managing COVID-19. They note that the body's vitamin C levels often drop during an acute infection due to increased metabolic demands. Because v…
Vitamin CCOVID-19SARS-CoV-2Beneficial effectsManagement - A+++2020
Continuous Ascorbate Infusions in the Management of Patients with Advanced Colon Cancer
Nina MikirovaThis study analyzed data from a previous clinical trial involving 17 patients with late-stage colon cancer. The patients received continuous intravenous infusions of vitamin C (ascorbate) over 6-8 weeks. Researchers fou…
Vitamin CAscorbic acidcolon cancer - A+++2020
Fasting-mimicking diet plus chemotherapy in breast cancer treatment
Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini, Filippo de BraudThis clinical trial investigated whether a fasting-mimicking diet (FMD) combined with chemotherapy could improve outcomes for breast cancer patients. The overall results were negative, meaning the study did not find a s…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; breast cancer - A+++2020
Healthy fats and exclusion-zone size
Abha Sharma, Gerald H PollackThis study investigated whether healthy fats can contribute to the formation of exclusion-zone (EZ) water, also known as the fourth phase of water. Researchers tested substances such as ghee, coconut oil, and lard to se…
Coconut oil; Exclusion-zone water; Fats; Ghee; Health-promoting function; Lard; UV–VIS spectroscopy - A+++2020
Movement Caused by Electrical Stimulation of the Lumbosacral Region in Standing Horses
Daniela C Riedler, Rebeka R Zsoldos, Matthias Robel, Isabelle D Jobst, Theresia F LickaThis study investigated how electrical stimulation (ES) affects movement in the lower back and pelvis of standing horses compared to manual techniques. While both methods successfully triggered movement in the lumbosacr…
Electrical stimulation; Lumbosacral; Pelvic inclination; Physical therapy; Sacroiliac - A+++2020
Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts
Torsten Lowin, Ren Tingting, Julia Zurmahr, Tim Classen, Matthias Schneider, Georg PongratzThis laboratory study investigated how cannabidiol (CBD) affects synovial fibroblasts, the cells responsible for joint destruction in rheumatoid arthritis. Researchers found that CBD can reduce the viability of these ce…
inflammationfibroblastCannabinoidsrheumatoid arthritissynovia - A+++2020
Effects of Cesarean Section and Vaginal Delivery on Abdominal Muscles and Fasciae
Chenglei Fan, Diego Guidolin, Serena Ragazzo, Caterina Fede, Carmelo Pirri, Nathaly Gaudreault, Andrea Porzionato, Vero…This study used ultrasound to compare the abdominal muscles and fascia of women who had a C-section, a vaginal delivery, or had never given birth. Researchers found that both types of delivery were associated with chang…
caesarean section; vaginal delivery; fascia; abdominal muscles; pain; ultrasound - A+++2020
Antiviral Mechanisms of Vitamin C: A Short Communication Consensus Report
Michael J Gonzalez, Jorge R Miranda-Massari, Jose R Rodriguez, Victor Marcial-Vega, Miguel J Berdiel, Jorge Duconge, St…This 2020 publication is a consensus report from a large group of authors, summarizing agreed-upon points regarding vitamin C. Based on the title, the report details the various mechanisms by which vitamin C may exert a…
Vitamin CAscorbic acidantiviral effects - A+++2020
Vitamin D insufficiency as a potential culprit in critical COVID-19 patients
Ruhul Munshi, Mohammad H Hussein, Eman A Toraih, Rami M Elshazli, Christina Jardak, Nasrin Sultana, Mohanad R Youssef,…In this systematic review, researchers analyzed data from six studies to explore the association between vitamin D levels and COVID-19 severity. They found that patients with a poor prognosis had significantly lower ser…
meta-analysisCOVID-19SARS-CoV-2vitamin Doutcome - A+++2020
The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 2
Bruno Bordoni, Stevan Walkowski, Bruno Ducoux, Filippo TobbiThis narrative review, the second in a series, discusses how modern scientific research challenges some of the original concepts of cranial osteopathy. The authors examine the mechanical characteristics of cranial struc…
fasciaManual TherapyOsteopathiccraniocraniosacral - A+++2020
Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation
Dennis Muñoz Vergara, Lisbeth Berrueta, Colleen Carmody, Xingxing An, Peter M Wayne, Ann Marie Zavacki, Helene M Langev…This animal study used a novel porcine model to investigate how active stretching affects controlled inflammation in the connective tissue of the back. Researchers trained pigs to perform a specific stretch twice daily…
Stretch - A+++2020
Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women
Cemal Ozemek, Kerry L Hildreth, Patrick J Blatchford, K Joseph Hurt, Rachael Bok, Douglas R Seals, Wendy M Kohrt, Kerri…This randomized pilot study investigated how a single dose of resveratrol or estradiol affects endothelial function in postmenopausal women. The findings suggest that while both substances can improve the blood vessels'…
aerobic exercise; endothelial function; nutraceutical; sex hormones; women - A+++2020
Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials
Natiele Camponogara Righi, Felipe Barreto Schuch, Angélica Trevisan De Nardi, Caroline Montagner Pippi, Geovana de Alme…This meta-analysis compiled results from 18 randomized clinical trials to investigate the effects of vitamin C supplementation following a single bout of exercise. The researchers found that vitamin C reduced certain ma…
inflammationOxidative stressexerciseathleteAscorbic acid - A+++2020
Gut Microbiota and Cardiovascular Disease
Marco Witkowski, Taylor L Weeks, Stanley L HazenThis review explores how the gut microbiota influences cardiovascular health through the production of specific metabolic byproducts. Research suggests that the link is not merely associative; certain bacterial metaboli…
atherosclerosis; cardiovascular diseases; gastrointestinal microbiome; thrombosis; vascular diseases - A+++2020
The immediate effect of IASTM vs. Vibration vs. Light Hand Massage on knee angle repositioning accuracy and hamstrings flexibility: A pilot study
George A Koumantakis, Eleonora Roussou, Georgios A Angoules, Nikolaos A Angoules, Theodoros Alexandropoulos, Georgia Ma…This pilot study compared the immediate effects of three different soft tissue techniques on the hamstrings of 16 healthy men. The techniques were instrument-assisted soft tissue mobilization (IASTM), vibration massage,…
fasciaproprioceptionMassageMuscle tightness - A+++2020
Prevention and treatment of COVID-19 infection by earthing
Haider Abdul-Lateef MousaThis observational study investigated the effects of 'earthing'—direct physical contact with the ground—in 59 people with COVID-19. Participants engaged in earthing for 15 minutes to 3 hours daily. The author reported t…
COVID-19; COVID-19 treatment; COVID-19 prevention; Earthing; Grounding; cytokine storm - A+++2020
The role of cannabinoids in the treatment of cancer
L Vecera, T Gabrhelik, P Prasil, P StouracThis review article summarizes current knowledge on how cannabinoids and their receptors modulate tumor diseases. Research suggests that cannabinoids may influence cancer progression by stimulating programmed cell death…
cancer; cannabinoid receptor; cannabinoids; oncological diseases cancer treatment - A+++2020
A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and "Medical Cannabinoids"
Renáta Szabó, Denise Börzsei, Zsuzsanna Szabó, Alexandra Hoffmann, István Zupkó, Dániel Priksz, Krisztina Kupai, Csaba…This animal study using an estrogen-deficient rat model investigated how the endocannabinoid anandamide (AEA) affects cardiovascular health during menopause-like conditions. Researchers found that estrogen loss reduced…
anandamide; cardiovascular system; heme oxygenase; nitric oxide synthase - A+++2020
Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial
Jay Jay Thaung Zaw, Peter R C Howe, Rachel H X WongThis 24-month randomized controlled crossover trial investigated the effects of daily resveratrol supplementation in 125 postmenopausal women. The findings suggest that taking 75 mg of resveratrol twice daily may reduce…
Resveratrolpolyphenolemenopause - A+++2020
Propolis-induced exclusion of colloids: Possible new mechanism of biological action
Magdalena Kowacz, Gerald H PollackThis laboratory study investigates how propolis (bee glue) interacts with water to create an exclusion zone (EZ)—a layer of water that repels solutes and microorganisms. The researchers found that surfaces coated with p…
Colloid-surface repulsion; Exclusion zone; Propolis - A+++2020
A Closer Look at Anandamide Interaction With TRPV1
Chante Muller, Diane L Lynch, Dow P Hurst, Patricia H ReggioThis study used advanced molecular dynamics simulations to investigate how anandamide, an endocannabinoid, interacts with the TRPV1 ion channel, which is central to pain perception. The researchers observed that anandam…
TRP channels; TRPV1; anandamide; cannabinoids; molecular dynamics - A+++2020
Mechanical stimulation of human dermal fibroblasts regulates pro-inflammatory cytokines: potential insight into soft tissue manual therapies
Aric Anloague, Aaron Mahoney, Oladipupo Ogunbekun, Taylor A Hiland, William R Thompson, Bryan Larsen, M Terry Loghmani,…This lab study investigated how mechanical forces, similar to those in manual therapy, affect human skin cells. Researchers first applied a repetitive strain to cultured dermal fibroblasts to simulate an overuse injury,…
inflammationMyofascial releaseManual Therapyphysical therapyphysiotherapy - A+++2020
Om vikten av att stärka immunförsvaret under covid-19
Mats Humble, Bo Jonsson, Per KågesonThis memo summarizes the state of knowledge on strengthening the immune system in the elderly to better manage COVID-19. The authors focus on findings that highlight the importance of maintaining adequate levels of spec…
VitaminsImmune system - A+++2020
Do Interventions with Diet or Dietary Supplements Reduce the Disease Activity Score in Rheumatoid Arthritis? A Systematic Review of Randomized Controlled Trials
Josefine Nelson, Helen Sjöblom, Inger Gjertsson, Stine M Ulven, Helen M Lindqvist, Linnea BärebringThis systematic review examined randomized controlled trials to determine if diet or dietary supplements can reduce disease activity in adults with rheumatoid arthritis. The researchers found moderate-strength evidence…
DAS28; Rheumatoid Arthritis; diet - A+++2020
Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles
Piero Pavan, Elena Monti, Michela Bondí, Chenglei Fan, Carla Stecco, Marco Narici, Carlo Reggiani, Lorenzo MarcucciThis study investigated why muscles become stiffer with age by comparing individual muscle fibers to bundles of fibers that include the extracellular matrix (ECM). Researchers found that while the stiffness of individua…
aging; collagen; extracellular matrix; resting tension; single muscle fiber; skeletal muscle. - A+++2020
Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis
Eduardo Dourado, Margarida Ferro, Catarina Sousa Guerreiro, João Eurico FonsecaThis narrative review explores how dietary patterns can influence the gut microbiota in individuals with rheumatoid arthritis (RA). Research indicates that RA patients often exhibit significant differences in their inte…
Mediterranean diet; gut microbiota; probiotics; rheumatoid arthritis - A+++2020
Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases
Paweł Śledziński, Agnieszka Nowak-Terpiłowska, Joanna ZeylandThis narrative review explores how cannabinoids, including those from plants and those produced naturally by the body, influence health through the endocannabinoid system. The authors describe how these compounds intera…
cancer medicine; cannabinoid receptors; cannabinoids; immune medicine - A+++2020
Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells
Wresti L Anggayasti, Chikahiro Imashiro, Taiki Kuribara, Kiichiro Totani, Kenjiro TakemuraResearchers are exploring mechanical vibration as a potential cancer therapy that avoids harming healthy cells. In this lab study, a brief, low-frequency vibration was applied to a line of human skin cancer cells (A431)…
apoptosismechanical vibrationcancer cell modelglucose metabolismhigh-mobility group box 1 - A+++2020
Perspective: Vitamin D deficiency and COVID-19 severity –plausibly linked by latitude, ethnicity, impacts on cytokines,ACE2 and thrombosis
J M Rhodes, S Subramanian, E Laird, G Griffin, R A KennyThis narrative review explores the potential link between vitamin D deficiency and the severity of COVID-19. The authors observed that countries at higher latitudes, with less sun exposure, had higher COVID-19 mortality…
cytokineCOVID-19vitamin D - A+++2020
The feasibility and impact of instrument-assisted manual therapy (IAMT) for the lower back on the structural and functional properties of the lumbar area in female soccer players: a randomised, placebo-controlled pilot study design
Patrick Weber, Christine Graf, Werner Klingler, Nadine Weber, Robert SchleipThis is a protocol for a pilot study designed to investigate the feasibility and impact of instrument-assisted manual therapy (IAMT) for the lower back in female soccer players. The researchers plan to compare IAMT with…
Thoracolumbar fasciaMyofascialultrasound.AthletesInstrument-assisted - A+++2020
Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer
Priyanga Selvakumar, Aja Badgeley, Paige Murphy, Hina Anwar, Urvashi Sharma, Katharine Lawrence, Ashakumary Lakshmikutt…This narrative review explores how dietary flavonoids and other polyphenols may influence breast cancer through epigenetic mechanisms. Research suggests that compounds found in green tea, soy, and berries can affect gen…
Epigenetics; breast cancer; chromatin modification; flavonoids; methylation - A+++2020
An anatomical comparison of the fasciae of the thigh: A macroscopic, microscopic and ultrasound imaging study
Carmelo Pirri, Caterina Fede, Lucia Petrelli, Diego Guidolin, Chenglei Fan, Raffaele De Caro, Carla SteccoResearchers compared the thigh's fascial layers using three methods: dissection of cadavers, microscopic analysis, and ultrasound imaging of living volunteers. They identified distinct layers, including a superficial fa…
fascia lataImagingThicknessmusculo-skeletal ultrasoundsuperficial fascia - A+++2020
Endocannabinoids release after Osteopathic Manipulative Treatment. A brief review
Andrea Buscemi, Simona Martino, Santi Scirè Campisi, Alessandro Rapisarda, Marinella CocoThis brief review examines how Osteopathic Manipulative Treatment (OMT) may influence the body's endocannabinoid system, which is crucial for pain regulation and emotional well-being. By analyzing existing research, the…
chronic pain; endocannabinoids; hypothalamic-pituitary-adrenal axis; osteopathic manipulative treatment - A+++2020
Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19
Minkyung Bae, Hyeyoung KimThis mini-review discusses how vitamin C, vitamin D, and selenium may affect the immune system in relation to COVID-19. Research suggests that deficiencies in these micronutrients are common in patients with acute respi…
COVID-19; infectious disease; selenium; virus; vitamin C; vitamin D - A+++2020
Collagen supplementation for skin health: A mechanistic systematic review
Meisam Barati, Masoumeh Jabbari, Roya Navekar, Fariba Farahmand, Reihaneh Zeinalian, Ammar Salehi-Sahlabadi, Nasrin Abb…This systematic review evaluates the impact of collagen supplementation on skin health and aging parameters. By analyzing ten clinical trials, researchers found that oral intake of both intact and hydrolyzed collagen co…
M2-like macrophage; collagen; collagen hydrolysate; oral tolerance; regulatory T cell; skin health. - A+++2020
The Five Diaphragms in Osteopathic Manipulative Medicine: Myofascial Relationships, Part 2
Bruno BordoniThis conceptual review article continues an examination of the "five diaphragms" concept within osteopathic manipulative medicine. The paper focuses on the myofascial connections along the front and sides of the body, e…
fasciaMyofascialOsteopathicdiaphragmphysiotherapy - A+++2020
The Five Diaphragms in Osteopathic Manipulative Medicine: Myofascial Relationships, Part 1
Bruno BordoniThis review article outlines the osteopathic concept of the body's "five diaphragms": the tentorium cerebelli, tongue, thoracic outlet, respiratory diaphragm, and pelvic floor. According to the osteopathic respiratory-c…
fasciaMyofascialOsteopathicdiaphragmphysiotherapy