Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation
- 01Establish a novel porcine model to study how stretching impacts inflammation
- 02Observe that active stretching reduced inflammatory lesion size by 36 percent
- 03Support the body's natural healing processes through controlled movement and stretching
- 04Note the anatomical similarities between porcine and human connective tissue in the back
Regular active stretching may help reduce localized inflammation and support the natural resolution of tissue injury.
Objective: Active stretching of the body is integral to complementary mind-body therapies such as yoga, as well as physical therapy, yet the biologic mechanisms underlying its therapeutic effects remain largely unknown. A previous study showed the impact of active stretching on inflammatory processes in rats. The present study tested the feasibility of using a porcine model, with a closer resemblance to human anatomy, to study the effects of active stretching in the resolution of localized inflammation.
Design: A total of 12 pigs were trained to stretch before subcutaneous bilateral Carrageenan injection in the back at the L3 vertebrae, 2 cm from the midline. Animals were randomized to no-stretch or stretch, twice a day for 5 mins over 48 hrs. Animals were euthanized for tissue collection 48 hrs postinjection.
Results: The procedure was well tolerated by the pigs. On average, lesion area was significantly smaller by 36% in the stretch group compared with the no-stretch group (P = 0.03).
Conclusion: This porcine model shows promise for studying the impact of active stretching on inflammation-resolution mechanisms. These results are relevant to understanding the stretching-related therapeutic mechanisms of mind-body therapies. Future studies with larger samples are warranted.
- APA
- Dennis Muñoz Vergara, Lisbeth Berrueta, Colleen Carmody, Xingxing An, Peter M Wayne, Ann Marie Zavacki, & Helene M Langevin (2020). Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation. https://fasciaresearchdatabase.com/establishment-of-a-novel-porcine-model-to-study-the-impact-of-active-stretching-on-a-local-carrageenan-induced-inflammation/
- MLA
- Dennis Muñoz Vergara, et al. "Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation." 2020, https://fasciaresearchdatabase.com/establishment-of-a-novel-porcine-model-to-study-the-impact-of-active-stretching-on-a-local-carrageenan-induced-inflammation/.
- Chicago
- Dennis Muñoz Vergara et al. 2020. "Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation.". https://fasciaresearchdatabase.com/establishment-of-a-novel-porcine-model-to-study-the-impact-of-active-stretching-on-a-local-carrageenan-induced-inflammation/
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