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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–3 of 3 studieshyaluronanA++Since 2015
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  1. A++
    2023

    Functional organization of extracellular hyaluronan, CD44 and RHAMM

    Mary K Cowman, Eva A Turley

    In this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…

    hyaluronanCD44extracellular matrixRHAMMpericellular matrix
  2. A++
    2019

    Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory

    Ramesh C Gupta, Rajiv Lall, Ajay Srivastava, Anita Sinha

    This narrative review explores hyaluronic acid (HA), a naturally occurring substance found in connective tissues and synovial fluid. HA is essential for joint lubrication and viscoelasticity, but its concentration and m…

    hyaluronanwound healingHyaluronic acidosteoarthritiscancer therapy
  3. A++
    2015

    Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

    Jaime M Cyphert, Carol S Trempus, Stavros Garantziotis

    This narrative review summarizes current knowledge about hyaluronan, a molecule whose biological effects are dependent on its size. Unlike many other molecules, hyaluronan's signaling properties are determined not by ch…

    hyaluronanCell signalingmolecular size