Myofibroblast
12 studies on Myofibroblast — reviewed, translated, woven together.
Articles
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Research
- 2015
Hyaluronan Regulates Bone Morphogenetic Protein-7- dependent Prevention and Reversal of Myofibroblast Phenotype
Adam C Midgley, Lucy Duggal, Robert Jenkins, Vincent Hascall, Robert Steadman, Aled O Phillips, Soma MeranThis study on human lung fibroblasts investigated how a protein called BMP7 might counteract fibrosis. Researchers found that BMP7 can prevent and even reverse the formation of myofibroblasts, which are cells that contr…
- 2015
Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts
Stephen P Evanko, Susan Potter-Perigo, Loreen J Petty, Gail A Workman, Thomas N WightThis study investigated how hyaluronan (HA), a key component of the extracellular matrix, influences the formation of myofibroblasts—cells involved in tissue scarring and fibrosis. Researchers observed that while HA lev…
- 2014
Fascia—Current knowledge and future directions in physiatry: Narrative review
E H Kwong, T W FindleyIn this 2014 narrative review, the authors discuss fascia from the perspective of physiatry, or rehabilitation medicine. They note that while fascia is part of the body's connective tissue, its definition is unclear in…
- 2014
Crosstalk between fibroblasts and inflammatory cells
S Van Linthout, K Miteva, C TschöpeThis narrative review describes how fibroblasts, traditionally seen as passive cells that produce extracellular matrix, are increasingly understood as active key players in the immune system. The authors provide an over…
- 2012
Recent Developments in Myofibroblast Biology
Boris Hinz, Sem H Phan, Victor J Thannickal, Marco Prunotto, Alexis Desmoulière, John Varga, Olivier De Wever, Marc Mar…This 2012 narrative review summarizes advances in understanding the myofibroblast, a specialized cell crucial for both normal wound healing and the development of fibrotic diseases. The authors discuss how these cells g…
- 2011
Fibroblasts and Myofibroblasts: What are we talking about?
Jennifer Baum, Heather S DuffyThis 2011 narrative review explores the roles of fibroblasts and myofibroblasts, two key cell types in the heart's connective tissue. Once considered static, research indicates these cells are dynamic and play an active…
- 2010
A new lock-step mechanism of matrix remodelling based on subcellular contractile events
Lysianne Follonier Castella, Lara Buscemi, Charles Godbout, Jean-Jacques Meister, Boris HinzMyofibroblasts are cells that contribute to tissue contracture in fibrotic conditions like scarring. This study investigated how these cells contract to remodel tissue. The researchers identified two separate contractio…
- 2007
Formation and Function of the Myofibroblast during Tissue Repair
Boris HinzMyofibroblasts are specialized cells that play a key role in wound healing and tissue repair. Formed from fibroblasts, their primary function is to contract, which helps pull the edges of a wound together. While this is…
- 2007
The Myofibroblast One Function, Multiple Origins
Boris Hinz, Sem H Phan, Victor J Thannickal, Andrea Galli, Marie-Luce Bochaton-Piallat, Giulio GabbianiThis 2007 review article discusses the myofibroblast, a cell type crucial for wound healing but also implicated in fibrosis, or pathological scarring. The authors highlight that while myofibroblasts perform similar func…
- 2005
Active fascial contractility: Fascia may be able to contract in a smooth muscle-like manner and thereby influence musculoskeletal dynamics
Robert Schleip, Werner Klingler, F Lehmann-HornFascia is typically viewed as a passive tissue that transmits force from muscles. This paper explores the hypothesis that fascia may also be able to actively contract on its own, similar to smooth muscle. Researchers po…
- 2002
Myofibroblasts and Mechanoregulation of Connective Tissue Remodelling
James J Tomasek, Giulio Gabbiani, Boris Hinz, Christine Chaponnier, Robert A BrownThis 2002 review discusses the myofibroblast, a specialized cell type that develops from fibroblasts and helps remodel connective tissue. These cells are crucial for wound healing, as their ability to contract helps clo…
- 2002
Myofibroblasts and Mechanoregulation of Connective Tissue Remodelling
James J Tomasek, Giulio Gabbiani, Boris Hinz, Christine Chaponnier, Robert A BrownThis 2002 review article discusses the role of myofibroblasts, a specialized type of cell, in remodeling connective tissue. These cells are crucial for wound healing, but their behavior is not fully understood. They app…
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