Integrins
14 studies on Integrins — reviewed, translated, woven together.
Articles
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Research
- 2019
Photo-crosslinked gelatin-hyaluronic acid methacrylate hydrogel-committed nucleus pulposus-like differentiation of adipose stromal cells for intervertebral disc repair
Pengfei Chen, Lei Ning, Pengcheng Qiu, Jian Mo, Sheng Mei, Chen Xia, Jianfeng Zhang, Xianfeng Lin, Shunwu FanThis animal study on rats investigated a new strategy for repairing degenerated intervertebral discs using stem cells. Researchers combined adipose-derived stromal cells (ASCs) with a special light-activated hydrogel ma…
- 2016
Coordinated integrin activation by actin-dependent force during T-cell migration
P Nordenfelt, H L Elliott, T A SpringerResearchers investigated how immune cells, specifically T-cells, generate the force needed to move. Using fluorescent tension sensors, they visualized the tension within integrins, which are proteins that help cells gri…
- 2014
Mechanotransduction and extracellular matrix homeostasis
Jay D Humphrey, Eric R Dufresne, Martin A SchwartzConnective tissues are dynamic, constantly adapting even at rest. Cells within these tissues continually sense mechanical cues from their environment through a process called mechanotransduction. In response, they maint…
- 2013
CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts?
Andrew LeaskMechanical tension is essential for the function and health of connective tissue. In skin fibroblasts, the protein integrin β1 plays a key role in adhesion and in regulating healing and fibrosis (scarring). This theoret…
- 2008
Tensegrity-Based Mechanosensing from Macro to Micro
Donald E IngberThis review article, based on a lecture, explores how cells convert mechanical signals into biochemical responses. The author proposes that the body uses "tensegrity" (tensional integrity) principles, where interconnect…
- 2008
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
Karl E Kadler, Adele Hill, Elizabeth G Canty-LairdThis 2008 review article explores how collagen fibrils, the main structural components of connective tissue, are formed. While collagen can self-assemble in a test tube, the process in living tissues is carefully manage…
- 2008
Tensegrity and Mechanotransduction
D E IngberThis article summarizes a lecture on how mechanical forces influence biological processes at the cellular level. The author describes mechanotransduction, the process by which cells convert physical forces into biochemi…
- 2007
Cell–Matrix Adhesion
Allison L Berrier, Kenneth M YamadaThe connection between cells and their surrounding extracellular matrix (ECM) is fundamental to how tissues are built and function. This matrix, composed of collagen and other proteins, not only provides structural supp…
- 2004
Integrins in Mechanotransduction
Akira Katsumi, A Wayne Orr, Eleni Tzima, Martin Alexander SchwartzThis 2004 review article examines how cells sense and respond to physical forces, a process known as mechanotransduction. The authors focus on integrins, a class of proteins that anchor cells to their surroundings and a…
- 2003
Mechanobiology and diseases of mechanotransduction
Donald E IngberThis 2003 article argues that medicine often overlooks the physical and mechanical aspects of disease, focusing instead on genetics. The author reviews how physical forces and the extracellular matrix are vital for norm…
Podcast
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