fibrosis
22 studies, 1 episode on fibrosis — reviewed, translated, woven together.
Articles
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Research
- 2022
Evidence of Renin-Angiotensin System Receptors in Deep Fascia: A Role in Extracellular Matrix Remodeling and Fibrogenesis?
Carmelo Pirri, Brasilina Caroccia, Andrea Angelini, Lucia Petrelli, Maria Piazza, Carlo Biz, Pietro Ruggieri, Raffaele…This study investigated the presence of renin-angiotensin system (RAS) components in deep fascia, specifically the thoracolumbar fascia. While RAS is best known for regulating blood pressure, it also plays a significant…
- 2020
The potential of cannabidiol in the COVID-19 pandemic
Giuseppe Esposito, Marcella Pesce, Luisa Seguella, Walter Sanseverino, Jie Lu, Chiara Corpetti, Giovanni SarnelliThis scientific hypothesis explores the potential of cannabidiol (CBD) as a supportive treatment during the COVID-19 pandemic. The authors suggest that CBD may down-regulate the receptors the virus uses for cellular ent…
- 2019
Role of matrix metalloproteinases 2 and 9 in the development of frozen shoulder: human data and experimental analysis in a rat contracture model
Chul-Hyun Cho, Yun-Mee Lho, Ilseon Hwang, Du Hwan KimThis study investigated the biological processes behind frozen shoulder, a condition characterized by pain and stiffness. Researchers analyzed joint capsule tissue from both patients with frozen shoulder and from a rat…
- 2017
Bi component T1p and T2 Relaxation Mapping of Skeletal Muscle In-Vivo
Azadeh Sharafi, Gregory Chang, Ravinder R RegatteResearchers evaluated a specific MRI technique for creating more detailed images of skeletal muscle. Using what is known as T1ρ and T2 relaxation mapping on the calf muscles of healthy volunteers, they were able to dist…
- 2017
Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis
Y Xiong, L Berrueta, K Urso, Sara Olenich, Igla Muskaj, G J Badger, A Aliprantis, R Lafyatis, H M LangevinThis animal study investigated the effects of stretching on systemic sclerosis, a condition that causes skin inflammation and fibrosis. Using a mouse model of the disease, researchers found that ten minutes of daily str…
- 2016
Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase
Sebastian Kalamajski, Dominique Bihan, Arkadiusz Bonna, Kristofer Rubin, Richard W FarndaleFibrosis is characterized by a dense and stiff collagen matrix, formed through a cross-linking process driven by the enzyme lysyl oxidase (LOX). This study investigated the role of another protein, fibromodulin, in this…
- 2015
Collagen Crosslinking Does Not Dictate Stiffness in a Transgenic Mouse Model of Skeletal Muscle Fibrosis
M A Chapman, R Pichika, R L LieberIn this animal study on mice, researchers investigated why fibrotic, or scarred, skeletal muscle becomes so stiff. While it is known that fibrosis involves an increase in collagen, the amount of collagen alone does not…
- 2015
Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?
S Albeiroti, A Soroosh, C A de la MotteThis 2015 review article explores the role of hyaluronan (HA) in fibrosis, a condition where excessive connective tissue buildup impairs organ function. HA is a key component of the extracellular matrix, known for its h…
- 2014
Painful Connections: Densification Versus Fibrosis of Fascia
P G Pavan, Antonio Stecco, R Stern, Carla SteccoIn this review article, the authors describe two types of fascial changes that can cause pain: densification and fibrosis. Densification is described as a reversible alteration in the viscosity of the loose connective t…
- 2013
CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts?
Andrew LeaskMechanical tension is essential for the function and health of connective tissue. In skin fibroblasts, the protein integrin β1 plays a key role in adhesion and in regulating healing and fibrosis (scarring). This theoret…
- 2012
A RHAMM Mimetic Peptide Blocks Hyaluronan Signaling and Reduces Inflammation and Fibrogenesis in Excisional Skin Wounds
Cornelia Tolg, Sara R Hamilton, Ewa Zalinska, Lori McCulloch, Ripal Amin, Natalia Akentieva, Francoise Winnik, Rashmin…In this animal study, researchers investigated how to reduce scarring during skin wound healing. They developed a peptide, P15-1, designed to interfere with signals from fragmented hyaluronan, a molecule involved in inf…
- 2012
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism
Jun Li, Daniel J Gorski, Wendy Anemaet, Jennifer Velasco, Jun Takeuchi, John D Sandy, Anna PlaasIn this mouse study, researchers investigated how hyaluronan (HA) injections might protect joints in osteoarthritis. They found that even though the injected HA was cleared from the knee joint in under two hours, a sing…
- 2012
Recent Developments in Myofibroblast Biology
Boris Hinz, Sem H Phan, Victor J Thannickal, Marco Prunotto, Alexis Desmoulière, John Varga, Olivier De Wever, Marc Mar…This 2012 narrative review summarizes advances in understanding the myofibroblast, a specialized cell crucial for both normal wound healing and the development of fibrotic diseases. The authors discuss how these cells g…
- 2012
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis
Kenneth E Lipson, Carol Wong, Yuchin Teng, Suzanne SpongFibrosis is a process of excessive connective tissue formation, leading to scarring and stiffness in organs. A protein called Connective Tissue Growth Factor (CTGF) plays a central role in driving this process. This res…
- 2011
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Thomas R Cox, Janine T ErlerIn this perspective article, the authors discuss how the extracellular matrix (ECM) is constantly being remodeled, a process essential for normal bodily functions like wound healing and tissue maintenance. When this rem…
- 2011
Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44
Yuejuan Li, Dianhua Jiang, Jiurong Liang, Eric B Meltzer, Alice Gray, Riu Miura, Lise Wogensen, Yu Yamaguchi, Paul W No…This study investigated the mechanisms behind severe lung fibrosis, a condition where excessive connective tissue builds up in the lungs. Using a mouse model, researchers found that fibroblasts, a type of connective tis…
- 2011
Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis
Carol A de la MotteThis narrative review explores the role of hyaluronan (HA) in intestinal health and disease. Chronic intestinal inflammation can lead to fibrosis, or scarring, a process driven by inflammatory signals and specialized ce…
- 2010
A new lock-step mechanism of matrix remodelling based on subcellular contractile events
Lysianne Follonier Castella, Lara Buscemi, Charles Godbout, Jean-Jacques Meister, Boris HinzMyofibroblasts are cells that contribute to tissue contracture in fibrotic conditions like scarring. This study investigated how these cells contract to remodel tissue. The researchers identified two separate contractio…
- 2008
Differential effects of hyaluronan and its fragments on fibroblasts: Relation to wound healing
Maha David-Raoudi, Frederic Tranchepain, Brigitte Deschrevel, Jean-Claude Vincent, Patrick Bogdanowicz, Karim Boumedien…This lab study investigated how hyaluronan (HA) of different molecular sizes affects human fibroblast cells, which are key to wound healing. Researchers exposed fibroblasts to native HA and two smaller fragments. All th…
- 2007
Formation and Function of the Myofibroblast during Tissue Repair
Boris HinzMyofibroblasts are specialized cells that play a key role in wound healing and tissue repair. Formed from fibroblasts, their primary function is to contract, which helps pull the edges of a wound together. While this is…
- 2007
The Myofibroblast One Function, Multiple Origins
Boris Hinz, Sem H Phan, Victor J Thannickal, Andrea Galli, Marie-Luce Bochaton-Piallat, Giulio GabbianiThis 2007 review article discusses the myofibroblast, a cell type crucial for wound healing but also implicated in fibrosis, or pathological scarring. The authors highlight that while myofibroblasts perform similar func…
- 2002
Myofibroblasts and Mechanoregulation of Connective Tissue Remodelling
James J Tomasek, Giulio Gabbiani, Boris Hinz, Christine Chaponnier, Robert A BrownThis 2002 review discusses the myofibroblast, a specialized cell type that develops from fibroblasts and helps remodel connective tissue. These cells are crucial for wound healing, as their ability to contract helps clo…