Articles
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Research
2
- 2013
CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts?
Andrew LeaskMechanical tension is essential for the function and health of connective tissue. In skin fibroblasts, the protein integrin β1 plays a key role in adhesion and in regulating healing and fibrosis (scarring). This theoret…
- 2004
TGF-beta signaling and the fibrotic response
Andrew Leask, David J AbrahamThis 2004 narrative review discusses the molecular basis of fibrotic diseases, which are characterized by excessive production and deposition of connective tissue. The authors summarize the state of knowledge concerning…
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