collagen synthesis
4 studies on collagen synthesis — reviewed, translated, woven together.
Articles
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Research
- 2011
Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments
Jennifer Z Paxton, Paul Hagerty, Jonathan J Andrick, Keith BaarThis study on engineered ligaments explored how different stretching patterns affect tissue development. Researchers used a bioreactor to apply cyclic stretch, measuring cellular responses by tracking a key protein call…
- 2009
From mechanical loading to collagen synthesis, structural changes and function in human tendon
Michael Kjær, H Langberg, K Heinemeier, M L Bayer, Mette Hansen, L Holm, S Doessing, M Kongsgaard, M R Krogsgaard, S P…This review article outlines how tendons adapt to mechanical loading from exercise. The research indicates that loading increases the synthesis and turnover of collagen, the protein that gives tendons their strength. Th…
- 2007
Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types
K M Heinemeier, J L Olesen, F Haddad, H Langberg, M Kjaer, K M Baldwin, P SchjerlingIn this animal study, researchers investigated how different types of muscle contractions (concentric, eccentric, and isometric) affect the gene expression of collagen and related growth factors in rats. The results sho…
- 2004
Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts
Jill E Kolodsick, Galen B Toews, Claudia Jakubzick, Cory Hogaboam, Thomas A Moore, Andrew McKenzie, Carol A Wilke, Cara…In this animal study, researchers investigated the drivers of lung fibrosis in mice. The team compared mice genetically deficient in the immune molecules IL-4, IL-13, or both. Results showed that mice lacking IL-13 were…
Podcast
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