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40 results for "hyaluronan"

Research

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2022
Title match
Hyaluronan homeostasis and its role in pain and muscle stiffness
Adam Amir, Soo Kim, Antonio Stecco, Michael P Jankowski, Preeti Raghavan
This narrative review explores the role of hyaluronan (HA) in the musculoskeletal system. HA is a key component of the extracellular matrix in muscles and fascia, where it normally functions as a lubricant and shock abs…
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2021
Title match
Hyaluronan and the Fascial Frontier
Rebecca L Pratt
This narrative review explores the role of hyaluronan (HA) in the body's fascial system. HA is a key component of the extracellular matrix, widely used in products from skin creams to joint injections for its ability to…
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2019
Title match
Hyaluronan fragments produced during tissue injury: A signal amplifying the inflammatory response
Angela Avenoso, Giuseppe Bruschetta, Angela D'Ascola, Michele Scuruchi, Giuseppe Mandraffino, Rosa Gullace, Antonino Saitta, Salvatore Campo, Giuseppe M Campo
This narrative review examines how fragments of hyaluronan (HA), a major component of the extracellular matrix, contribute to inflammation. During tissue injury, large HA molecules are broken down into smaller pieces. E…
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2019
Title match
Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer
Anastasia G Tavianatou, Ilaria Caon, Marco Franchi, Zoi Piperigkou, Devis Galesso, Nikos K Karamanos
This narrative review explores how hyaluronan (HA), a key component of the extracellular matrix, functions differently depending on its molecular size. Large, high-molecular weight HA has different biological properties…
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2019
Title match
Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor
Stephan Thönes, Sandra Rother, Tom Wippold, Joanna Blaszkiewicz, Kanagasabai Balamurugan, Stephanie Moeller, Gloria Ruiz-Gómez, Matthias Schnabelrauch, Dieter…
This study investigated a new type of hydrogel designed to improve wound healing. Researchers combined collagen and hyaluronan (HA), a natural component of connective tissue, with a growth factor that stimulates skin ce…
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2017
Title match
Hyaluronan as a therapeutic target in human diseases
Jiurong Liang, Dianhua Jiang, Paul W Noble
This narrative review explores the role of hyaluronan, a major component of the extracellular matrix involved in tissue injury and repair. Its function varies significantly with its size; fragmented hyaluronan can promo…
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2016
Title match
Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration
Michele M Temple-Wong, Shuwen Ren, Phu Quach, Bradley C Hansen, Albert C Chen, Akihiko Hasegawa, Darryl D D’Lima, Jim Koziol, Koichi Masuda, Martin K Lotz, Rob…
This study investigated how the lubricant hyaluronan in knee joint fluid changes with age and cartilage wear. Researchers analyzed synovial fluid from human donors aged 23 to 91 without diagnosed osteoarthritis. They fo…
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2015
Title match
Hyaluronan, inflammation and breast cancer progression
Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthy
This narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…
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