32 results for "mechanotransduction"
Research
- 2019Topic match
Biophysics of Cell-Substrate Interactions Under Shear
Neha Paddillaya, Ashish Mishra, Paturu Kondaiah, Pramod Pullarkat, Gautam I Menon, Namrata Gundiah
In this review article, the authors examine how cells adhere to surfaces and respond to mechanical forces. Cells use complex structures called focal adhesions to sense and react to their environment, including forces fr…
A - 2019Topic match
The plasma membrane as a mechanochemical transducer
Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs
In this review article, researchers describe how the plasma membrane, the cell's outer boundary, acts as a key sensor for mechanical forces. The membrane senses and responds to physical stresses from its environment, su…
A - 2015Topic match
Fascia and Primo Vascular System
Chun Yang, Yi-kuan Du, Jian-bin Wu, JunWang, Ping Luan, Qin-lao Yang, Lin Yuan
In this review article, the authors explore the idea that the body's network of fascia may be the physical structure corresponding to acupuncture meridians in Traditional Chinese Medicine (TCM). They also discuss the pr…
1A+ - 2003Topic match
Tensegrity II. How structural networks influence cellular information processing networks
Donald E Ingber
This theoretical article, the second in a two-part series, explores how a cell's physical structure influences its internal signaling and behavior. It builds on the "tensegrity" model, which describes the cell's skeleto…
A - 2022Topic match
Mechanosensing by Piezo1 and its implications for physiology and various pathologies
Austin Lai, Charles D Cox, Nadia Chandra Sekar, Peter Thurgood, Anthony Jaworowski, Karlheinz Peter, Sara Baratchi
This narrative review explores Piezo1, a specialized ion channel that senses mechanical pressure and converts it into biological signals within the body. These channels are widely distributed in tissues such as blood ve…
A++ - 2021Topic match
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration
Bingjin Wang, Wencan Ke, Kun Wang, Gaocai Li, Liang Ma, Saideng Lu, Qian Xiang, Zhiwei Liao, Rongjin Luo, Yu Song, Wenbin Hua, Xinghuo Wu, Yukun Zhang, Xianlin…
This study investigates how the mechanical environment of the intervertebral disc influences cellular health during disc degeneration. Researchers found that as the central part of the disc (nucleus pulposus) becomes st…
A++ - 2020Topic match
The Structure and Role of Intramuscular Connective Tissue in Muscle Function
Peter P Purslow
This narrative review analyzes the microscopic structure of intramuscular connective tissue—endomysium, perimysium, and epimysium—and its role in muscle function. Rather than acting simply as a container, this connectiv…
A++ - 2020Topic match
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo Zou
This study using mouse models investigates how the protein PIEZO1 acts as a mechanical sensor in the skeleton to regulate bone mass. Researchers found that a deficiency of PIEZO1 in bone-forming cells (osteoblasts) lead…
A++