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63 results for "inflammation"

Research

30

2020
Topic match
A Hyaluronan-binding Peptide (P15-1) Reduces inflammatory and catabolic events in IL-1beta-treated human articular chondrocytes
Claire Shortt, Leonard G Luyt, Eva A Turley, Mary K Cowman, Thorsten Kirsch
Inflammation in osteoarthritis drives cartilage degradation. In this laboratory study, researchers investigated whether a peptide (P15-1) combined with hyaluronan (HA) could protect human cartilage cells in a simulated…
A
2019
Topic match
Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology
Priya Rangan, Inyoung Choi, MinWei, Gerardo Navarrete, Esra Guen, Sebastian Brandhorst, Nobel Enyati, Gab Pasia, Daral Maesincee, Vanessa Ocon, Maya Abdulridha…
This study investigates how cycles of a fasting-mimicking diet (FMD) affect inflammatory bowel disease (IBD) in both mice and humans. In animal models, FMD cycles reduced intestinal inflammation, encouraged the growth o…
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2019
Topic match
Hyaluronan fragments produced during tissue injury: A signal amplifying the inflammatory response
Angela Avenoso, Giuseppe Bruschetta, Angela D'Ascola, Michele Scuruchi, Giuseppe Mandraffino, Rosa Gullace, Antonino Saitta, Salvatore Campo, Giuseppe M Campo
This narrative review examines how fragments of hyaluronan (HA), a major component of the extracellular matrix, contribute to inflammation. During tissue injury, large HA molecules are broken down into smaller pieces. E…
B
2019
Topic match
Lymphatic pump manipulation in patients with chronic obstructive pulmonary disease
Bruno Bordoni
This narrative review examines the use of lymphatic pump manipulation for patients with chronic obstructive pulmonary disease (COPD). COPD is characterized by persistent inflammation, and lymphatic techniques aim to red…
A
2019
Topic match
Role of matrix metalloproteinases 2 and 9 in the development of frozen shoulder: human data and experimental analysis in a rat contracture model
Chul-Hyun Cho, Yun-Mee Lho, Ilseon Hwang, Du Hwan Kim
This study investigated the biological processes behind frozen shoulder, a condition characterized by pain and stiffness. Researchers analyzed joint capsule tissue from both patients with frozen shoulder and from a rat…
A
2019
Topic match
Role of Hyaluronan in Inflammatory Effects on Human Articular Chondrocytes
Mary K Cowman, Claire Shortt, Shivani Arora, Yuhong Fu, Jemma Villavieja, Jai Rathore, Xiayun Huang, Tatini Rakshit, Gyu Ik Jung, Thorsten Kirsch
Some researchers have proposed that fragments of hyaluronan (HA), a key molecule in connective tissue, can trigger inflammation in cartilage. This study investigated that idea in human articular cartilage cells. Researc…
A
2024
Topic match
Gut-Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond
Julia Zißler, Veit Rothhammer, Mathias Linnerbauer
This narrative review explores how the interaction between the gut microbiome and the brain influences the progression of multiple sclerosis (MS). The researchers describe how imbalances in gut bacteria can lead to bact…
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2022
Topic match
Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
Claudio Vernieri, Giovanni Fucà, Francesca Ligorio, Veronica Huber, Andrea Vingiani, Fabio Iannelli, Alessandra Raimondi, Darawan Rinchai, Gianmaria Frigè, Ant…
This clinical trial investigated the safety and biological effects of a five-day fasting-mimicking diet (FMD) in 101 cancer patients receiving standard treatments. The results suggest that the diet is safe and leads to…
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