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40 results for "hyaluronan"

Research

30

2023
Title match
Functional organization of extracellular hyaluronan, CD44 and RHAMM
Mary K Cowman, Eva A Turley
In this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…
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2020
Title match
Sensitivity of the Fasciae to the Endocannabinoid System: Production of Hyaluronan-Rich Vesicles and Potential Peripheral Effects of Cannabinoids in Fascial Tissue
Caterina Fede , Carmelo Pirri , Lucia Petrelli, Diego Guidolin , Chenglei Fan, Raffaele De Caro, Carla Stecco
This laboratory study investigated how fascial cells respond to cannabinoids. Researchers isolated fibroblast cells from human fascia lata and treated them with a substance that activates cannabinoid receptor 2. The tre…
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2020
Title match
A Hyaluronan-binding Peptide (P15-1) Reduces inflammatory and catabolic events in IL-1beta-treated human articular chondrocytes
Claire Shortt, Leonard G Luyt, Eva A Turley, Mary K Cowman, Thorsten Kirsch
Inflammation in osteoarthritis drives cartilage degradation. In this laboratory study, researchers investigated whether a peptide (P15-1) combined with hyaluronan (HA) could protect human cartilage cells in a simulated…
A
2019
Title match
TMEM2: a missing link in hyaluronan catabolism identified?
Yu Yamaguchi, Hayato Yamamoto, Yuki Tobisawa, Fumitoshi Irie
Hyaluronan (HA) is a large molecule in our connective tissues that is broken down and replaced very quickly. Scientists have long understood that large HA molecules are first chopped into smaller pieces on the surface o…
B
2019
Title match
Role of Hyaluronan in Inflammatory Effects on Human Articular Chondrocytes
Mary K Cowman, Claire Shortt, Shivani Arora, Yuhong Fu, Jemma Villavieja, Jai Rathore, Xiayun Huang, Tatini Rakshit, Gyu Ik Jung, Thorsten Kirsch
Some researchers have proposed that fragments of hyaluronan (HA), a key molecule in connective tissue, can trigger inflammation in cartilage. This study investigated that idea in human articular cartilage cells. Researc…
A
2019
Title match
Intravascular heavy chain-modification of hyaluronan during endotoxic shock
Kevin Ni, Amar Gill, Danting Cao, Kengo Koike, Kelly S Schweitzer, Stavros Garantziotis, Irina Petrache
In this animal study, researchers investigated why a specific molecule, HC-modified hyaluronan (HC-HA), is critical for survival in systemic inflammation (like endotoxic shock) but less so in localized lung inflammation…
A
2019
Title match
Evaluation of hyaluronan content in areas of densification compared to adjacent areas of fascia
E J Hughes, K McDermott, M F Funk
This entry is currently a title only, so a full summary is not available. Based on the title, the researchers appear to have evaluated and compared the hyaluronan content in areas of fascial densification with the conte…
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2018
Title match
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini , Sanna Pasonen-Seppänen
Astrocytomas are the most common type of brain tumor in adults. In this retrospective study, researchers investigated hyaluronan, a key component of the brain's extracellular matrix, and its related enzymes in 163 tumor…
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