Search

32 results for "mechanotransduction"

Research

30

2009
Title match
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Ning Wang, Jessica D Tytell, Donald E Ingber
In this narrative review, the authors explore how mechanical forces can influence the cell nucleus from a distance. Research has often focused on how external forces are converted into chemical signals at the cell's sur…
A
2014
Title match
Mechanotransduction and extracellular matrix homeostasis
Jay D Humphrey, Eric R Dufresne, Martin A Schwartz
Connective tissues are dynamic, constantly adapting even at rest. Cells within these tissues continually sense mechanical cues from their environment through a process called mechanotransduction. In response, they maint…
A
2008
Title match
Mechanotransduction – a field pulling together?
Christopher S Chen
In this 2008 review article, the author discusses mechanotransduction, the process by which cells convert mechanical forces into biochemical signals. Cells are constantly subjected to forces, both from external pressure…
A
2007
Title match
Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering
Kevin K Parker, Donald E Ingber
This narrative review explores the challenges of engineering artificial heart tissue. The heart functions across vast scales of time and space, from tiny ion channels to the whole organ's pumping action. The authors sug…
A
2013
Title match
Understanding mechanotransduction and biotensegrity from an adaptation perspective
Leon Chaitow
This article, for which only the title is available, appears to be a conceptual exploration of mechanotransduction and biotensegrity. Mechanotransduction is the process by which cells sense and respond to mechanical for…
B
2006
Title match
Cellular mechanotransduction: putting all the pieces together again
D E Ingber
This review discusses how cells sense and respond to mechanical forces, a process called mechanotransduction. While many individual molecules involved in this process have been identified, it is less clear how they work…
1A+
2016
Title match
Piezo2 is the principal mechanotransduction channel for proprioception
Seung-Hyun Woo, Viktor Lukacs, Joriene C de Nooij, Dasha Zaytseva, Connor R Criddle, Allain Francisco, Thomas M Jessell, Katherine A Wilkinson, Ardem Patapouti…
Proprioception is the sense of where our body parts are in space. In this animal study, researchers investigated the molecular sensor responsible for this ability in mice. They found that an ion channel called Piezo2 wa…
A+
2020
Topic match
Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation
Andrew E Miller, Ping Hu, Thomas H Barker
This narrative review describes how cells and their surrounding environment, the extracellular matrix (ECM), constantly communicate with each other. This communication involves physical cues from the ECM being translate…
A