Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A2020
A new clinical trial to test high-dose vitamin C in patients with COVID-19
Anitra C CarrThis 2020 entry by Anitra C. Carr announces a new clinical trial. The study was designed to investigate the effects of high-dose vitamin C on patients with COVID-19. As this is only a title entry, no details about the s…
Vitamin CCOVID-19corona virushigh-dose C - A2019
High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
Ling-Hui Zeng, Qing-Mei Wang, Lin-Yi Feng, Yu-Dun Ke, Qian-Zi Xu, An-Yi Wei, Chong Zhang, Rong-Biao YingThis study on breast cancer cells in the lab and in mice explored how different doses of vitamin C affect cancer cell behavior. Researchers found that low and medium doses of vitamin C seemed to encourage cancer cells t…
Breast cancermetastasisTGF-β1Vitamin C - A2013
Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
Anitra C Carr, Stephanie M Bozonet, Juliet M Pullar, Jeremy W Simcock, Margreet C M VissersThis study investigated how vitamin C intake affects its concentration in human skeletal muscle. Researchers gave 36 men either half a kiwifruit or two kiwifruits daily for six weeks, as kiwifruit is a rich source of vi…
Vitamin Cascorbate - A2011
The Genetics of Vitamin C Loss in Vertebrates
Guy Drouin, Jean-Rémi Godin, Benoît PagéThis narrative review explores why some vertebrate species, including humans, cannot produce their own Vitamin C. The inability to synthesize this crucial nutrient, important for collagen and antioxidant functions, stem…
BiosynthesisVitamin CAscorbic acidGLO geneL-gulono-gamma-lactone oxidase - A2008
Anti-angiogenic effect of high doses of ascorbic acid
Nina A Mikirova, Thomas E Ichim, Neil H RiordanThis laboratory study investigated how high doses of ascorbic acid (vitamin C) affect the formation of new blood vessels, a process called angiogenesis. Researchers exposed several types of human endothelial cells, incl…
AngiogenesisVitamin CAscorbic acid - A2007
Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial
Yoo-Sin Park, Si-Woong Lim, Il-Hoon Lee, Tae-Jin Lee, Jong-Sung Kim, Jin Soo HanIn this animal study, researchers investigated if injecting a simple nutrient solution could protect knee cartilage in rabbits with induced osteoarthritis. The solution, containing glucose, amino acids, and vitamin C, w…
nutritionosteoarthritisVitamin Cascorbateintra articular - A2003
Vitamin C, respiratory infections and the immune system
Harri HemiläThis 2003 publication by Harri Hemilä explores the relationship between Vitamin C, respiratory infections, and immune system function. As only the title is available, specific conclusions regarding the study's exact res…
Vitamin CAscorbic acid - A1994
Glutathione-Ascorbic Acid Antioxidant System in Animals
Alton MeisterThis 1994 publication by Alton Meister discusses the biochemical interaction between glutathione and ascorbic acid (Vitamin C) within animal antioxidant systems. As the source material is limited to the title, the summa…
Vitamin CAscorbic acidantioxidantanimals - A1978
Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
EWAN CAMERON, LINUS PAULINGThis study compared the survival times of 100 terminal cancer patients who received supplemental ascorbate (vitamin C) with 1000 matched control patients who did not. The ascorbate-treated group was found to have a mean…
cancerVitamin Cascorbate