Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804

studies

602

top-graded

2,783

with plain-language summary

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Showing 1–12 of 12 studiescollagen A

A
2019
Oral Collagen Supplementation: A Systematic Review of Dermatological Applications
Franchesca D Choi, Calvin T Sung, Margit L W Juhasz, Natasha Atanaskova Mesinkovsk
This systematic review examined eleven clinical trials investigating the impact of oral collagen supplements on skin health. The findings suggest that collagen hydrolysates and peptides may improve skin elasticity, hydr…
wound healingcollagenskin aging
A
2013
Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective
Lisa D Muiznieks, Fred W Keeley
This review article examines the extracellular matrix (ECM), the dynamic network of molecules surrounding our cells. The authors focus on fibrous proteins like collagen and elastin, which form the structural backbone of…
fasciaextracellular matrixcollageneastinself-assembly
A
2011
Exercise training reduces fibrosis and matrix metalloproteinase dysregulation in the aging rat heart
Hyo-Bum Kwak, Jong-hee Kim, Kumar Joshi, Alvin Yeh, Daniel A Martinez, John M Lawler
In this animal study, researchers investigated how exercise affects age-related fibrosis (scarring) in the rat heart. They found that aging was associated with an increase in collagen and a dysregulation of enzymes call…
collagenRemodelingTIMP-1
A
2011
The extracellular matrix: an active or passive player in fibrosis?
T N Wight, S Potter-Perigo
Fibrosis, the excessive buildup of scar tissue, can be understood as a wound healing process that has gone awry. Normally, specialized cells called myofibroblasts help repair tissue and then disappear, but in fibrosis,…
fasciaprovisional extracellular matrixmyofibroblatcollagenhyaluronan proteoglycans
A
2010
3D reconstruction of the crural and thoracolumbar fasciae
L Benetazzo, A Bizzego, R De Caro, G Frigo, D Guidolin, Carla Stecco
Researchers created detailed 3D computer models to visualize the structure of the crural fascia in the lower leg and the superficial layer of the thoracolumbar fascia in the lower back. They found the crural fascia is c…
Connective tissuecollagenThoracolumbar fasciacrural fascia3D models
A
2009
Relevance of Collagen Piezoelectricity to “Wolff’s Law”: a Critical Review
Andrew C Ahn, Alan J Grodzinsky
This narrative review explores how bone adapts to mechanical stress, a principle known as Wolff's Law. For decades, scientists have investigated how bone cells sense this stress to trigger remodeling. An early theory pr…
fasciacollagenpiezoelectricwolff's law
A
2008
Differential effects of hyaluronan and its fragments on fibroblasts: Relation to wound healing
Maha David-Raoudi, Frederic Tranchepain, Brigitte Deschrevel, Jean-Claude Vincent, Patrick Bogdanowicz, Karim Boumedien…
This lab study investigated how hyaluronan (HA) of different molecular sizes affects human fibroblast cells, which are key to wound healing. Researchers exposed fibroblasts to native HA and two smaller fragments. All th…
hyaluronanfasciawound healingextracellular matrixfibrosis
A
2006
Subcutaneous Tissue Fibroblast Cytoskeletal Remodeling Induced by Acupuncture: Evidence for a Mechanotransduction-Based Mechanism
Helene M Langevin, Nicole A Bouffard, Gary J Badger, David L Churchill, Alan K Howe
In this mouse tissue study, researchers investigated how rotating an acupuncture needle affects fibroblasts in the connective tissue under the skin. They found that rotation caused the fibroblasts to actively change sha…
fasciacollagenfibroblastcytoskeletonmechanotransduction
A
2004
Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
MICHAEL KJÆR
This review discusses how the extracellular matrix (ECM), particularly collagen, adapts to mechanical loading in tendons and muscles. Physical activity stimulates both the creation and breakdown of collagen, a process e…
collagentendonsMechanical loadingECMskeletal muscles
A
2001
Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture
Helene M Langevin, David L Churchill, Marilyn J Cipolla
This paper proposes a hypothesis for how acupuncture might work. The authors focus on the "de qi" sensation, which includes the acupuncturist feeling a "needle grasp" in the tissue. They suggest that when an acupuncture…
collagenmechanotransductionmeridian
A
1993
Angiogenic oligosaccharides of hyaluronan enhance the production of collagens by endothelial cells
P Rooney, M Wang, P Kumar, S Kumar
This study investigated how small fragments of hyaluronan (HA) affect collagen production during the formation of new blood vessels, a process called angiogenesis. Researchers observed that applying these HA fragments t…
hyaluronancollagenAngiogenesis
A
1979
THE INFLUENCE OF MECHANICAL FORCES ON THE GLYCOSAMINOGLYCAN CONTENT OF THE RABBIT FLEXOR DIGITORUM PROFUNDUS TENDON
GERALD C GILLARD, HELEN C REILLY, PAUL G BELL-BOOTH, MICHAEL H FLINT
In this animal study on rabbits, researchers surgically altered the mechanical forces on a deep finger flexor tendon to observe how the tissue adapted. They analyzed how the content of glycosaminoglycans (GAGs)—molecule…
collagenLoadingECMGAGdeep digital flexor tendon