Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Local Estrogen Therapy for Pelvic Organ Prolapse in Postmenopausal Women: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis analyzed seven randomized controlled trials to evaluate the impact of local estrogen therapy on pelvic organ prolapse in postmenopausal women. The findings suggest that while the…
The Flares of Low back pain with Activity Research Study (FLAReS): study protocol for a case-crossover study nested within a cohort study
This study protocol describes the FLAReS project, which aims to clarify the complex relationship between physical activity and low back pain flares. The researchers intend to distinguish between transient, short-term ef…
Fascial Nomenclature: Update 2021, Part 1
This review article discusses the need for clear, scientifically grounded terminology for the fascial system. The authors, representing the FORCE organization, emphasize the importance of an impartial approach to fascia…
The Effects of Cannabis on Female Reproductive Health Across the Life Course
This narrative review examines how cannabis affects female reproductive health throughout life, from fertility to menopause. While endocannabinoid receptors are present in the reproductive tract, human research remains…
Fascial Nomenclature: Update 2021, Part 2
This conceptual article addresses the ongoing debate about how to classify and name fascia. The authors suggest that progress is hindered because the discussion is often limited to a few scientific specialties and can b…
Neural Coding of Vibration Intensity
This study investigated how the brain processes different intensities of vibration using electroencephalography (EEG). Researchers applied no, low, or high-intensity vibration to participants' index fingers while measur…
Whole body vibration in the static modified push-up position in untrained healthy women stimulates neuromuscular system potentiating increased handgrip myogenic response
This study investigated the acute effects of vibration on handgrip strength in untrained women. Participants placed their hands on a vibrating platform in a modified push-up position for five minutes. Researchers found…
Comparison of the therapeutic outcomes between open plantar fascia release and percutaneous radiofrequency ablation in the treatment of intractable plantar fasciitis
This retrospective study compared two surgical treatments for severe, persistent plantar fasciitis: open plantar fascia release and percutaneous radiofrequency ablation. Researchers analyzed outcomes for 31 patients nea…
Reflections on the Development of Fascial Tissue: Starting from Embryology
This reflective article discusses the ongoing challenges in classifying fascial tissue. The authors highlight that the scientific literature contains many contradictions and lacks a clear, straightforward definition. Th…
Telocytes inhibited inflammatory factor expression and enhanced cell migration in LPS-induced skin wound healing models in vitro and in vivo
This study investigated the role of telocytes, a type of connective tissue cell, in skin wound healing. Using both mouse models and cell cultures, researchers explored how these cells behave in inflamed wounds. They fou…
The MyotonPRO: a reliable and valid tool for quantifying the viscoelastic properties of a trigger point on the infraspinatus in non-traumatic chronic shoulder pain
Objectively measuring trigger points is a clinical challenge that typically relies on palpation. This study evaluated a handheld device, the MyotonPRO, on 35 individuals with chronic, non-traumatic shoulder pain. Resear…
Effects of vibration therapy on neuromuscular efficiency & features of the EMG signal based on endurance test
This study investigated how vibration therapy at different frequencies (23 Hz and 35 Hz) affects forearm muscle performance and fatigue. Researchers used electromyography (EMG) to measure electrical activity in four for…
Anatomy, Head and Neck, Anterior Vagus Nerve
This article is an anatomical description of the anterior vagus nerve in the head and neck. As only the title is available, the content has not yet been summarized in detail. The title suggests the text provides an over…
Role of fascial connectivity in musculoskeletal dysfunctions: A narrative review
This narrative review examines the concept of "fascial connectivity," which suggests that muscles and fascia are linked in functional chains throughout the body. The authors analyzed 35 studies, including cadaveric, ani…
PIEZO2: A Novel Molecule Involved in the Development of AIS
This case-control study investigated the potential link between the PIEZO2 gene, proprioception (the body's sense of position), and adolescent idiopathic scoliosis (AIS). Researchers found that AIS patients often exhibi…
Pilates exercise improves the clinical and immunological pro!les of patients with human T-cell lymphotropic virus 1 associated myelopathy: A pilot study
This pilot study investigated the effects of a 10-week Pilates program for eight patients with the chronic inflammatory disease HAM/TSP. After the exercise period, participants experienced significant improvements in pa…
Quantitative analysis of gliding between subcutaneous tissue and the vastus lateralis - Influence of the dense connective tissue of the myofascia
This study investigated the relationship between the thickness of connective tissue layers and their ability to glide past one another. Using ultrasound, researchers observed the vastus lateralis muscle on the outer thi…
A Hyaluronan-binding Peptide (P15-1) Reduces inflammatory and catabolic events in IL-1beta-treated human articular chondrocytes
Inflammation in osteoarthritis drives cartilage degradation. In this laboratory study, researchers investigated whether a peptide (P15-1) combined with hyaluronan (HA) could protect human cartilage cells in a simulated…
The link between vitamin D and COVID-19: distinguishing facts from fiction
This 2020 article, available only by title, appears to be a review or commentary on the relationship between vitamin D and COVID-19. The title, "The link between vitamin D and COVID-19: distinguishing facts from fiction…
Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province
This retrospective study analyzed clinical data from 137 patients with the novel coronavirus (2019-nCoV) hospitalized in China's Hubei province during the initial outbreak. The most common initial symptoms were fever, c…
A Novel Role of Ascorbic Acid in Anti-Inflammatory Pathway and ROS Generation in HEMA Treated Dental Pulp Stem Cells
Components from common dental resins can sometimes cause inflammation and oxidative stress in the cells of the dental pulp. This laboratory study investigated whether ascorbic acid (Vitamin C) could protect human dental…
A new clinical trial to test high-dose vitamin C in patients with COVID-19
This 2020 entry by Anitra C. Carr announces a new clinical trial. The study was designed to investigate the effects of high-dose vitamin C on patients with COVID-19. As this is only a title entry, no details about the s…
Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis
This review article discusses how mechanical loading affects tendons and ligaments. While normal levels of loading are essential for maintaining tissue health, pathological levels of force act as a stressor that can tri…
Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation
This narrative review describes how cells and their surrounding environment, the extracellular matrix (ECM), constantly communicate with each other. This communication involves physical cues from the ECM being translate…
Symptomatology correlations between the diaphragm and irritable bowel syndrome
This narrative review explores the potential connection between the diaphragm muscle and Irritable Bowel Syndrome (IBS). The authors propose that an altered contractile ability of the diaphragm and different breathing p…
T1ρ‐Mapping for Musculoskeletal Pain Diagnosis: Case Series of Variation of Water Bound Glycosaminoglycans Quantification before and after Fascial Manipulation® in Subjects with Elbow Pain
In this small case series, researchers evaluated five patients with chronic elbow pain. Using an advanced MRI technique (T1ρ-mapping), they measured the concentration of bound and unbound water in the deep fascia before…
A randomized clinical trial for the effect of static stretching and strengthening exercise on pelvic tilt angle in LBP patients
This randomized clinical trial investigated whether stretching or strengthening tight hamstrings could change pelvic posture in people with low back pain. Forty-five participants were divided into three groups: static s…
Identification of Telocytes in the Pancreas of Turtles—A role in Cellular Communication
In this animal study, researchers examined the pancreas of turtles to look for a specific cell type called telocytes. Using advanced microscopy and other laboratory techniques, they confirmed for the first time that the…
Calf stretching and plantar fascia-specific stretching for plantar fasciitis: A systematic review and meta-analysis
This systematic review and meta-analysis looked at eight studies to compare two common stretching techniques for plantar fasciitis: calf stretching and plantar fascia-specific stretching. The authors analyzed the data t…
Day of peak pain reduction by a single session of dry needling in the upper trapezius myofascial trigger points: A 14 daily follow-up study
This study tracked daily pain in people with upper trapezius trigger points following a single dry needling session. Participants received one treatment combined with self-stretching exercises and reported their pain fo…
Iliopsoas muscle thickness and pelvic alignment in pronated and normal foot postures
This study investigated whether chronic foot hyperpronation is linked to changes in pelvic alignment and iliopsoas muscle thickness. Researchers compared a group of women with pronated feet to a group with normal foot p…
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
This review article explores the relaxin hormone and its receptor, RXFP1, a signaling pathway known for its ability to soften ligaments and connective tissue. While relaxin shows potent antifibrotic potential in laborat…
Ageing of the diaphragm muscle
This narrative review explores how the diaphragm, our main breathing muscle, is affected by aging. Like other muscles, the diaphragm can weaken and lose mass over time, a condition known as sarcopenia. This age-related…
Muscle Cramps
Muscle cramps are involuntary, painful, and localized contractions of a muscle or muscle fibers, often felt as a palpable knot. While common in sports, their exact cause is not fully understood and likely depends on var…
Evaluation of scapular mobilization and comparison to pectoralis minor stretching in individuals with rounded shoulder posture: A randomized controlled trial
This randomized controlled trial investigated treatments for rounded shoulder posture in 52 healthy students. Researchers compared the effects of scapular mobilization, pectoralis minor self-stretching, and a combinatio…
Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity
Astronauts lose bone and muscle in space, partly because their cells become less responsive to mechanical forces. This study investigated if low-intensity vibration (LIV) could help counteract this effect in a lab setti…
Virtual reality in the rehabilitation process for individuals with cerebral palsy and Down syndrome: A systematic review
This systematic review compiled research on virtual reality (VR) as a rehabilitation tool for children with cerebral palsy and Down syndrome. Researchers analyzed five high-quality studies and found that VR training, bo…
Neuroanatomy, Cranial Nerve 11 (Accessory)
This review article describes the anatomy and function of the 11th cranial nerve, the accessory nerve. This nerve is essential for neck and shoulder movement, controlling key muscles like the trapezius and sternocleidom…
Structural remodelling of the lumbar multifidus, thoracolumbar fascia and lateral abdominal wall perimuscular connective tissues: A cross-sectional and comparative ultrasound study
Researchers used ultrasound to compare soft tissues in the lower back and abdomen of people with and without non-acute low back pain (LBP). They measured the multifidus muscle, the thoracolumbar fascia, and the connecti…
Acute Effects of Dynamic Stretching Followed by Vibration Foam Rolling on Sports Performance of Badminton Athlets
This study investigated the effects of two different warm-up routines on the performance of badminton athletes. Researchers compared dynamic stretching (DS) alone to a combination of dynamic stretching followed by vibra…
Anatomy, Tendons
This is a placeholder for a summary of a publication titled "Anatomy, Tendons". The full text has not yet been reviewed by our team. Once summarized, this entry will provide an overview of the key anatomical features of…
Lymphatic treatments after orthopedic surgery or injury: A systematic review
This systematic review examined the effectiveness of lymphatic and compression therapies for reducing swelling and pain after orthopedic surgery or injury. Researchers analyzed 15 studies, finding that for persistent sw…