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The Fascia Guide

Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–7 of 7 studiesinflammationASince 2015
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  1. A
    2020

    A Hyaluronan-binding Peptide (P15-1) Reduces inflammatory and catabolic events in IL-1beta-treated human articular chondrocytes

    Claire Shortt, Leonard G Luyt, Eva A Turley, Mary K Cowman, Thorsten Kirsch

    Inflammation in osteoarthritis drives cartilage degradation. In this laboratory study, researchers investigated whether a peptide (P15-1) combined with hyaluronan (HA) could protect human cartilage cells in a simulated…

    hyaluronaninflammationchondrocytesP15-1IL-1beta
  2. A
    2019

    Lymphatic pump manipulation in patients with chronic obstructive pulmonary disease

    Bruno Bordoni

    This narrative review examines the use of lymphatic pump manipulation for patients with chronic obstructive pulmonary disease (COPD). COPD is characterized by persistent inflammation, and lymphatic techniques aim to red…

    inflammationfasciaOsteopathicCOPDlymphatic pump
  3. A
    2019

    Role of matrix metalloproteinases 2 and 9 in the development of frozen shoulder: human data and experimental analysis in a rat contracture model

    Chul-Hyun Cho, Yun-Mee Lho, Ilseon Hwang, Du Hwan Kim

    This study investigated the biological processes behind frozen shoulder, a condition characterized by pain and stiffness. Researchers analyzed joint capsule tissue from both patients with frozen shoulder and from a rat…

    inflammationfibrosisfrozen shoulderimmobilizationrat; matrix metalloproteinases
  4. A
    2018

    Neuroinflammation and central sensitization in chronic and widespread pain

    Ru-Rong Ji, Andrea Nackley, Yul Huh, Niccolò Terrando, William Maixner

    Chronic pain is partly maintained by central sensitization, a state where the nervous system becomes hypersensitive. This review discusses how neuroinflammation—inflammation in the nervous system—contributes to this pro…

    inflammationchronic paainneuroinflammationsensitization
  5. A
    2015

    Innervation Changes Induced by Inflammation of the Thoracolumbar Fascia

    U Hoheisel, J Rosner, S Mense

    This animal study investigated how inflammation affects the nerves in the thoracolumbar fascia (TLF) of rats. Researchers induced inflammation in the TLF and compared its nerve fiber density to that of healthy fascia. W…

    inflammationfasciafasciitisfascia innervationsympathetic fibers
  6. A
    2015

    Hyaluronan, inflammation and breast cancer progression

    Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthy

    This narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…

    hyaluronaninflammationCD44fasciaBreast cancer
  7. A
    2015

    Evidence for the existence of nociceptors in rat thoracolumbar fascia

    S Mense, U Hoheisel

    This animal study on rats investigated the presence of pain-sensing nerve fibers (nociceptors) in the thoracolumbar fascia. Researchers compared normal fascia with tissue in which they had induced inflammation. The resu…

    inflammationfasciafasciitisnon-specific low back painfascia nociceptors