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The Fascia Guide

Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–5 of 5 studiescollagenA++
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  1. A++
    2020

    The Structure and Role of Intramuscular Connective Tissue in Muscle Function

    Peter P Purslow

    This narrative review analyzes the microscopic structure of intramuscular connective tissue—endomysium, perimysium, and epimysium—and its role in muscle function. Rather than acting simply as a container, this connectiv…

    extracellular matrixMusclecollagenmechanotransductionperimysium
  2. A++
    2019

    Mechanics and structural stability of the collagen triple helix

    Michael W H Kirkness, Kathrin Lehmann, Nancy R Forde

    This narrative review explores the mechanical properties of collagen, the body's primary structural protein. Collagen's unique triple helix structure is believed to be the source of its stability and resilience in tissu…

    collagentriple helix
  3. A++
    2019

    Effects of season long participation on ACL volume in female intercollegiate soccer athletes

    Karen M Myrick, Andreas Voss, Richard S Feinn, Thomas Martin, Bernadette M Mele, Juan C Garbalosa

    This study investigated how a competitive season affects the anterior cruciate ligament (ACL) in female collegiate soccer players. Researchers used MRI scans to measure ACL volume in 17 athletes before and after their s…

    collagenAnterior cruciate ligamentintense physical trainingvolumetric changes in ligamentpre- to post season changes in ligament
  4. A++
    2019

    Rehabilitation and nutrition protocols for optimising return to play from traditional ACL reconstruction in elite rugby union players: A case study

    Gregory Shaw, Ben Serpell, Keith Baar

    This case report followed two professional rugby players undergoing rehabilitation after an anterior cruciate ligament (ACL) reconstruction. In addition to a standard rehabilitation program, they received specific suppl…

    collagenRehabilitationnutritionACL
  5. A++
    2014

    The role of collagen crosslinks in ageing and diabetes - the good, the bad, and the ugly

    Jess G Snedeker, Alfonso Gautieri

    This narrative review explores how glucose in the body can bind to proteins like collagen, a process called glycation. This process creates crosslinks that can change the mechanical properties and function of connective…

    collagenCrosslinksageingadvanced glycation endproductstendon mechanics