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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 1–22 of 22 studies1A+Since 2015
Clear
1A+2019

Fascia Is Able to Actively Contract and May Thereby Influence Musculoskeletal Dynamics: A Histochemical and Mechanographic Investigation

Robert Schleip, G Gabbiani, Jan Wilke, I Naylor, B Hinz, A Zorn, Heike Jäger, R Breul, S Schreiner, Werner Klingler

This study investigated whether fascia can actively contract, challenging the traditional view of it as a passive tissue. Researchers examined human and rat fascial samples for the presence of contractile cells called m…

Connective tissuestiffnessmyofibroblasts
1A+2019

Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production

Caterina Fede, Carmelo Pirri, Chenglei Fan, Giovanna Albertin, Andrea Porzionato, Veronica Macchi, Raffaele De Caro, Ca…

Women experience myofascial pain more often than men, and evidence suggests fascia can be influenced by sex hormones. In this lab study, researchers examined how cells from human fascia lata responded to various levels…

fasciacollagen Icollagen III
1A+2019

A Primitive Trait in Two Breeds of Equus Caballus Revealed by Comparative Anatomy of the Distal Limb

Sharon May-Davis, Zefanja Vermeulen, Wendy Y Brown

This comparative anatomy study investigated the lower limbs of 574 equids, including 18 horse breeds, donkeys, zebras, and Przewalski's horses. Researchers looked for two specific ligamentous structures that are remnant…

2nd3rd4th Interosseous muscle; Dutch Konik; Bosnian Mountain Horse; Donkey; Przewalski; Zebra; Atavism
1A+2019

The Awareness of the Fascial System

Bruno Bordoni, Marta Simonelli

In this theoretical article, the authors propose a new way of looking at the fascial system, drawing on concepts from quantum physics. They suggest that fascial cells can sense, remember, and even anticipate mechanical…

fasciafascial systemMyofascial
1A+2019

Role of fasciae in nonspecific low back pain

G Casato, Carla Stecco, R Busin

Research increasingly links the thoracolumbar fascia to non-specific low back pain. This small case study explored the idea that pain could originate elsewhere in the body's continuous fascial network. Five patients wit…

fascianonspecific low back painlimb myofascial manipulation
1A+2019

The fascial breath

Bruno Bordoni, Marta Simonelli, Bruno Morabito

This narrative review proposes a new way of understanding the diaphragm muscle, moving beyond a purely mechanical view. The authors argue that the diaphragm is not just covered by fascia but is fundamentally a fascial t…

fasciaMyofascialOsteopathic
1A+2019

The Other Side of the Fascia: Visceral Fascia, Part 2

Bruno Bordoni, Marta Simonelli, Bruno Morabito

This editorial, part two of a series, argues for including certain internal organs (viscera) within the definition of fascia. From an osteopathic perspective, the authors suggest that understanding these organs as fasci…

fasciaMyofascialOsteopathic
1A+2019

The Other Side of the Fascia: The SmoothMuscle Part 1

Bruno Bordoni, Marta Simonelli, Bruno Morabito

This theoretical article challenges the standard definition of fascia. Traditionally, fascia is considered connective tissue originating from two embryonic layers, the mesoderm and ectoderm. The authors propose expandin…

fasciaMyofascialOsteopathic
1A+2019

Bone Tissue is an Integral Part of the Fascial System

Bruno Bordoni, Maria Marcella Lagana

This review article proposes that bone tissue should be considered an integral part of the fascial system, a departure from the current definition. The authors support this by highlighting the shared embryological origi…

fasciaBonefascial system
1A+2018

Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model

L Berrueta, J Bergholz, D Munoz, I Muskaj, G J Badger, A Shukla, H J Kim, J J Zhao, H M Langevin

In this mouse study, researchers investigated the effect of daily stretching on breast cancer tumors. Mice with implanted tumor cells were divided into two groups, with one group receiving gentle stretching for 10 minut…

StretchingTumor growthBreast cancer
1A+2018

From mechanobiology to developmentally inspired engineering

Donald Ingber

This review article, based on a lecture, explores the field of mechanobiology, which studies the central role of physical forces in development and physiology. The author reviews 40 years of his laboratory's foundationa…

Tensegritymechanicalorgans-on-chips
1A+2018

Effect of Stretching on Thoracolumbar Fascia Injury and Movement Restriction in a Porcine Model

H M Langevin, J Bishop, R Maple, G J Badger, J R Fox

In this animal study on pigs, researchers investigated the effect of stretching on the thoracolumbar fascia after injury and movement restriction. An injury combined with restricted movement led to reduced fascial mobil…

fasciaConnective tissueStretching
1A+2018

The Equine Hindlimb Proximal Suspensory Ligament: an Assessment of Health and Function by Means of Its Damping Harmonic Oscillator Properties, Measured Using an Acoustic Myography System: a New Modality Study

Jillian Costello Chavers, A Kent Allen, Waqas Ahmed, Lene Høeg Fuglsang-Damgaard, Adrian P Harrison

This study in horses explored a new method called acoustic myography (AMG) to help diagnose injuries in the proximal suspensory ligament (PSL) of the hindlimb. Researchers used a device to record sound signals from the…

equineCUROAcoustic myography
1A+2018

Equine Manual Therapies in Sport Horse Practice

Kevin K Haussler

Manual therapies can provide diagnostic and therapeutic approaches for assessing and managing neuromuscular coordination and strength in sport horses. This review describes various techniques, including active and passi…

osteopathyManual Therapyproprioception
1A+2018

The Fasciacytes- A New Cell Devoted To Fascial Gliding Regulation

Carla Stecco, Caterina Fede, Veronica Macchi, Andrea Porzionato, Lucia Petrelli, Carlo Biz, Robert Stern, Raffaele De C…

Researchers have identified a new type of cell within fascia, which they have named "fasciacytes." This study presents evidence that these specialized cells are responsible for producing hyaluronan, a key component of t…

hyaluronanfasciafasciacytes
1A+2017

Emotions in Motion: Myofascial Interoception

B Bordoni, F Marelli

In this perspective piece, the authors argue that the myofascial system is closely linked to our emotional state. They suggest that manual treatment not only affects the body physically but also activates the interocept…

fasciaManual TherapyMyofascial
1A+2016

Hormone receptor expression in human fascial tissue

Caterina Fede, G Albertin, L Petrelli, M M Sfriso, C Biz, R De Caro, Carla Stecco

Adult women tend to experience more myofascial pain than men, and this study explored a possible hormonal link. Researchers examined fascial tissue from eight female volunteers, looking for receptors for the hormones es…

Fascia; fascial fibroblasts; estrogen; relaxin; immunostaining
1A+2016

Expression of the endocannabinoid receptors in human fascial tissue

Caterina Fede, G Albertin, L Petrelli, M M Sfriso, C Biz, R De Caro, Carla Stecco

Researchers investigated whether human fascia contains cannabinoid receptors, which are part of the body's endocannabinoid system. Taking small tissue samples from volunteers during orthopedic surgery, they analyzed the…

fascia; fascial fibroblasts; endocannabinoid; immunostaining
1A+2016

STRETCHING IMPACTS INFLAMMATION RESOLUTION IN CONNECTIVE TISSUE

L Berrueta, I Muskaj, S Olenich, T Butler, G J Badger, R A Colas, M Spite, C N Serhan, H M Langevin

In this animal study, researchers investigated the effect of stretching on acute inflammation in the connective tissue of rats. After inducing local inflammation in the rats' backs, one group was subjected to twice-dail…

Stretching; SPM; Resolvin; Inflammation; Connective tissue
1A+2015

Gymnastic Training and Dynamic Mobilization Exercises Improve Stride Quality and Increase Epaxial Muscle Size in Therapy Horses

Kátia de Oliveira, Ricardo V G Soutello, Ricardo da Fonseca, Ciniro Costa, Paulo R de L Meirelles, Daniele F Fachiolli,…

This study on therapy horses investigated how specific exercises affect stride and back muscles. Over three months, nine horses were divided into three groups: a control group, one doing dynamic mobilization exercises,…

Hippotherapytherapeutic exercisedynamic mobilization exercise
1A+2015

Electron microscopy of human fascia lata: focus on telocytes

Joanna Dawidowicz, Sylwia Szotek, Natalia Matysiak, Łukasz Miela!nczyk, Krzysztof Maksymowicz

This study used an electron microscope to examine the types of cells present in the fascia lata, a sheet of connective tissue in the thigh. For the first time, researchers confirmed the existence of a specific cell type…

Fibroblastsmyofibroblastshuman fascia lata
1A+2015

Fascia and Primo Vascular System

Chun Yang, Yi-kuan Du, Jian-bin Wu, JunWang, Ping Luan, Qin-lao Yang, Lin Yuan

In this review article, the authors explore the idea that the body's network of fascia may be the physical structure corresponding to acupuncture meridians in Traditional Chinese Medicine (TCM). They also discuss the pr…

fasciamechanotransductionprimo vascular system