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The Fascia Guide

Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–4 of 4 studies1A+++Since 2010With summary
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  1. 1A+++
    2018

    Emission of Biophotons and Adjustable Sounds by the Fascial System: Review and Reflections for Manual Therapy

    Bruno Bordoni, F Marelli, B Morabito, B Sacconi

    In this narrative review, the authors explore how fascia, the web of connective tissue enveloping everything in the body, might communicate. They discuss research suggesting the fascial system may emit faint light parti…

    fasciaMuscleManual TherapyMyofascialOsteopathic
  2. 1A+++
    2018

    Quantification of hyaluronan in human fasciae: variations with function and anatomical site

    Caterina Fede, A Angelini, R Stern, V Macchi, A Porzionato, P Ruggieri, R De Caro, Carla Stecco

    This study quantified for the first time the amount of hyaluronan (HA), a key lubricant, in human fascia from different parts of the body. Since HA is essential for the smooth gliding between fascial layers, understandi…

    densification; extracellular matrix; fascia; fibrosis; gliding; hyaluronan; myofascial pain
  3. 1A+++
    2015

    Viscoelastic Properties of Hyaluronan in Physiological Conditions

    Mary K Cowman, Tannin A Schmidt, Preeti Raghavan, Antonio Stecco

    Hyaluronan (HA) is a molecule that gives the fluid in our connective tissues its viscous, gel-like quality. This viscosity is crucial for the smooth gliding of fascial layers against muscles and other tissues. Factors l…

    Hyalyronian acidhaviscositylubricationviscoelasticity
  4. 1A+++
    2011

    Hyaluronan within fascia in the etiology of myofascial pain

    Carla Stecco, R Stern, A Porzionato, V Macchi, S Masiero, Antonio Stecco, R De Caro

    In this cadaver and ultrasound study, researchers examined the composition of deep fascia. They identified layers of hyaluronan (HA), a lubricating substance, between the fascia and muscle, as well as between the fascia…

    fasciaHyaluronic acidSliding systemLoose connective tissueFasciacyte