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The straight line hypothesis elaborated: Case reference obesity, an argument for acidosis, oxidative stress, and disease conglomeration

Shoma Berkemeyer
Oxidative stressobesityacidosisproton imbalance
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Key takeaways
  1. 01Explores the link between obesity and oxidative stress
  2. 02Proposes proton imbalance (acidosis) as a possible mechanism
  3. 03The imbalance may inhibit cellular energy production
  4. 04May explain the connection between obesity and other diseases

This review suggests a biochemical link where proton imbalance in obesity could drive oxidative stress, potentially connecting it to other chronic diseases.

Abstract

Studies report on the association between obesity and oxidative stress, with and without additional diseases. Macrophages in adipocytes, and hypoxia in adipose tissue have been suggested to explain how obesity can relate to oxidative stress. The straight line hypothesis using the lactic acid trap construct has been put forward to explain how proton imbalance can relate to obesity. Proton imbalance has been also reported to associate with the production of reactive oxygen species by inhibition of mitochondrial energy production. This review brings together existing literature and concepts to explain how obesity can relate to oxidative stress via protons, uniquely for itself or, as often observed, in conglomeration of additional diseases.

Cite this study
APA
Shoma Berkemeyer (2010). The straight line hypothesis elaborated: Case reference obesity, an argument for acidosis, oxidative stress, and disease conglomeration. https://fasciaresearchdatabase.com/the-straight-line-hypothesis-elaborated-case-reference-obesity-an-argument-for-acidosis-oxidative-stress-and-disease-conglomeration/
MLA
Shoma Berkemeyer. "The straight line hypothesis elaborated: Case reference obesity, an argument for acidosis, oxidative stress, and disease conglomeration." 2010, https://fasciaresearchdatabase.com/the-straight-line-hypothesis-elaborated-case-reference-obesity-an-argument-for-acidosis-oxidative-stress-and-disease-conglomeration/.
Chicago
Shoma Berkemeyer. 2010. "The straight line hypothesis elaborated: Case reference obesity, an argument for acidosis, oxidative stress, and disease conglomeration.". https://fasciaresearchdatabase.com/the-straight-line-hypothesis-elaborated-case-reference-obesity-an-argument-for-acidosis-oxidative-stress-and-disease-conglomeration/