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Hyaluronan and its catabolic products in tissue injury and repair

P W Noble

hyaluronan inflammation CD44 respons to injury

Key takeaways

01Hyaluronan is a key component of connective tissue structure
02Large hyaluronan molecules support tissue integrity
03After injury, hyaluronan breaks down into smaller fragments
04These fragments have different biological roles in tissue repair

After an injury, large structural hyaluronan molecules break down into smaller fragments that play a distinct role in healing.

Abstract

Hyaluronan is an unbiquitous glycosaminoglycan present in most tissues. Under homeostatic conditions hyaluronan exists as a high molecular mass polymer that has important roles in tissue structural integrity. Under conditions of stress such as following tissue injury, hyaluronan becomes depolymerized and lower molecular mass polymers are generated. The biological properties of these hyaluronan fragments appear to be distinct from the larger precursor molecules. This review examines the biological role of hyaluronan fragments in tissue injury and repair.

Cite this study

APA: P W Noble (2001). Hyaluronan and its catabolic products in tissue injury and repair. https://fasciaresearchdatabase.com/hyaluronan-and-its-catabolic-products-in-tissue-injury-and-repair/
MLA: P W Noble. "Hyaluronan and its catabolic products in tissue injury and repair." 2001, https://fasciaresearchdatabase.com/hyaluronan-and-its-catabolic-products-in-tissue-injury-and-repair/.
Chicago: P W Noble. 2001. "Hyaluronan and its catabolic products in tissue injury and repair.". https://fasciaresearchdatabase.com/hyaluronan-and-its-catabolic-products-in-tissue-injury-and-repair/