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Intag av frukt, grönsaker och C-vitamin och C-vitamin i plasma: tvärsnittssamband med insulinresistens och glykemi hos 9-10-åriga barn

A S Donin, J E Dent, C M Nightingale, N Sattar, C G Owen, A R Rudnicka, M R Perkin, A M Stephen, S A Jebb, D G Cook, P H Whincup
Vitamin CInsulinresistensGlycaemiaDiabetes typ 2
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Nyckelinsikter
  1. 01Högre C-vitaminnivå i blodet var kopplat till lägre insulinresistens hos barn
  2. 02Rapporterat kostintag av C-vitamin visade inget samband med dessa markörer
  3. 03Lägre C-vitamin kan delvis förklara etniska skillnader i insulinresistens
  4. 04Studien visar ett samband, inte ett orsak-verkan-förhållande

Hos 9–10-åringar var högre C-vitaminnivåer i blodet, men inte det rapporterade kostintaget, kopplat till bättre metabola hälsomarkörer.

Abstract

Aim: To examine whether low circulating vitamin C concentrations and low fruit and vegetable intakes were associated with insulin resistance and other Type 2 diabetes risk markers in childhood.

Methods: We conducted a cross-sectional, school-based study in 2025 UK children aged 9-10 years, predominantly of white European, South-Asian and black African origin. A 24-h dietary recall was used to assess fruit, vegetable and vitamin C intakes. Height, weight and fat mass were measured and a fasting blood sample collected to measure plasma vitamin C concentrations and Type 2 diabetes risk markers.

Results: In analyses adjusting for confounding variables (including socio-economic status), a one interquartile range higher plasma vitamin C concentration (30.9 μmol/l) was associated with a 9.6% (95% CI 6.5, 12.6%) lower homeostatic model assessment of insulin resistance value, 0.8% (95% CI 0.4, 1.2%) lower fasting glucose, 4.5% (95% CI 3.2, 5.9%) lower urate and 2.2% (95% CI 0.9, 3.4%) higher HDL cholesterol. HbA1c concentration was 0.6% (95% CI 0.2, 1.0%) higher. Dietary fruit, vegetable and total vitamin C intakes were not associated with any Type 2 diabetes risk markers. Lower plasma vitamin C concentrations in South-Asian and black African-Caribbean children could partly explain their higher insulin resistance.

Conclusions: Lower plasma vitamin C concentrations are associated with insulin resistance and could partly explain ethnic differences in insulin resistance. Experimental studies are needed to establish whether increasing plasma vitamin C can help prevent Type 2 diabetes at an early stage.

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APA
A S Donin, J E Dent, C M Nightingale, N Sattar, C G Owen, A R Rudnicka, M R Perkin, A M Stephen, S A Jebb, D G Cook, & P H Whincup (2015). Intag av frukt, grönsaker och C-vitamin och C-vitamin i plasma: tvärsnittssamband med insulinresistens och glykemi hos 9-10-åriga barn. https://fasciaresearchdatabase.com/fruit-vegetable-and-vitamin-c-intakes-and-plasma-vitamin-c-cross-sectional-associations-with-insulin-resistance-and-glycaemia-in-9-10-year-old-children/
MLA
A S Donin, et al. "Intag av frukt, grönsaker och C-vitamin och C-vitamin i plasma: tvärsnittssamband med insulinresistens och glykemi hos 9-10-åriga barn." 2015, https://fasciaresearchdatabase.com/fruit-vegetable-and-vitamin-c-intakes-and-plasma-vitamin-c-cross-sectional-associations-with-insulin-resistance-and-glycaemia-in-9-10-year-old-children/.
Chicago
A S Donin et al. 2015. "Intag av frukt, grönsaker och C-vitamin och C-vitamin i plasma: tvärsnittssamband med insulinresistens och glykemi hos 9-10-åriga barn.". https://fasciaresearchdatabase.com/fruit-vegetable-and-vitamin-c-intakes-and-plasma-vitamin-c-cross-sectional-associations-with-insulin-resistance-and-glycaemia-in-9-10-year-old-children/
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