Extracellulära vesiklar frisatta från artikulära kondrocyter spelar en viktig roll i cell-cell-kommunikation
- 01Extracellulära vesiklar (EV) transporterar bioaktiva molekyler som proteiner och RNA mellan celler
- 02Exosomer och mikrovesiklar är de främsta typerna av vesiklar som används för cellsignalering
- 03Dessa vesiklar hjälper till att upprätthålla vävnadshomeostas och reglera olika immunsvar
- 04Vesiklarnas innehåll påverkas av genetiska faktorer, miljö och pågående sjukdomsprocesser
Extracellulära vesiklar fungerar som specialiserade transportbehållare som gör det möjligt för celler att kommunicera och reglera vävnadshälsa på avstånd.
The purpose of this investigation was to determine the role of extracellular vesicles (EVs), released from articular chondrocytes in a physiological or pathological state, in cell-cell communication with other articular chondrocytes or chondrocyte precursor cells. The conditioned medium from interleukin-1β (IL-1β)-treated human articular chondrocytes stimulated catabolic events and inhibited type II collagen expression in articular chondrocytes to a much greater degree than medium from IL-1β-treated chondrocytes after complete removal of EVs. The vehicle-treated and IL-1β-treated human articular chondrocytes released EVs of similar size; however, the number of EVs released by IL-1β-treated chondrocytes was markedly higher than the number of EVs released from the vehicle-treated cells. Furthermore, our findings demonstrate that similar to medium from IL-1β-treated chondrocytes containing EVs, EVs isolated from medium of IL-1β-treated chondrocytes stimulated catabolic events in articular chondrocytes, whereas EVs isolated from the medium of vehicle-treated chondrocytes inhibited catabolic events and increased messenger RNA levels of aggrecan and type II collagen in IL-1β-treated chondrocytes. Furthermore, the medium containing EVs from vehicle-treated articular chondrocytes or EVs isolated from this medium stimulated chondrogenesis of C3H10T1/2 cells, whereas medium containing EVs from IL-1β-treated chondrocytes or EVs isolated from this medium inhibited chondrogenesis. Our findings suggest that EVs released by articular chondrocytes play a key role in the communication between joint cells and ultimately in joint homeostasis, maintenance, pathology, and repair.
- APA
- Xiaoming Liu, Claire Shortt, Fenglin Zhang, Mariah Q Bater, Mary K Cowman, & Thorsten Kirsch (2020). Extracellulära vesiklar frisatta från artikulära kondrocyter spelar en viktig roll i cell-cell-kommunikation. https://fasciaresearchdatabase.com/extracellular-vesicles-released-from-articular-chondrocytes-play-a-major-role-in-cell-cell-communication/
- MLA
- Xiaoming Liu, et al. "Extracellulära vesiklar frisatta från artikulära kondrocyter spelar en viktig roll i cell-cell-kommunikation." 2020, https://fasciaresearchdatabase.com/extracellular-vesicles-released-from-articular-chondrocytes-play-a-major-role-in-cell-cell-communication/.
- Chicago
- Xiaoming Liu et al. 2020. "Extracellulära vesiklar frisatta från artikulära kondrocyter spelar en viktig roll i cell-cell-kommunikation.". https://fasciaresearchdatabase.com/extracellular-vesicles-released-from-articular-chondrocytes-play-a-major-role-in-cell-cell-communication/