Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2020
A Hyaluronan-binding Peptide (P15-1) Reduces inflammatory and catabolic events in IL-1beta-treated human articular chondrocytes
Claire Shortt, Leonard G Luyt, Eva A Turley, Mary K Cowman, Thorsten KirschInflammation in osteoarthritis drives cartilage degradation. In this laboratory study, researchers investigated whether a peptide (P15-1) combined with hyaluronan (HA) could protect human cartilage cells in a simulated…
hyaluronaninflammationchondrocytesP15-1IL-1beta - A+++2020
Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials
Natiele Camponogara Righi, Felipe Barreto Schuch, Angélica Trevisan De Nardi, Caroline Montagner Pippi, Geovana de Alme…This meta-analysis compiled results from 18 randomized clinical trials to investigate the effects of vitamin C supplementation following a single bout of exercise. The researchers found that vitamin C reduced certain ma…
inflammationOxidative stressexerciseathleteAscorbic acid - A+++2020
Mechanical stimulation of human dermal fibroblasts regulates pro-inflammatory cytokines: potential insight into soft tissue manual therapies
Aric Anloague, Aaron Mahoney, Oladipupo Ogunbekun, Taylor A Hiland, William R Thompson, Bryan Larsen, M Terry Loghmani,…This lab study investigated how mechanical forces, similar to those in manual therapy, affect human skin cells. Researchers first applied a repetitive strain to cultured dermal fibroblasts to simulate an overuse injury,…
inflammationMyofascial releaseManual Therapyphysical therapyphysiotherapy - A+++2020
Manipulation of the Fascial System Applied During Acute Inflammation of the Connective Tissue of the Thoracolumbar Region Affects Transforming Growth Factor-β1 and Interleukin-4 Levels: Experimental Study in Mice
Maria Elisa Duarte França, Larissa Sinhorim, Daniel Fernandes Martins, Robert Schleip, Nicolas A M M Machado-Pereira, G…This animal study investigated the effects of manual fascial manipulation on acute inflammation in the connective tissue of mice's lower backs. Researchers induced inflammation and then applied a specific manipulation p…
inflammationcytokinesfascial systemManipulationmice - A+++2020
Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts
Torsten Lowin, Ren Tingting, Julia Zurmahr, Tim Classen, Matthias Schneider, Georg PongratzThis laboratory study investigated how cannabidiol (CBD) affects synovial fibroblasts, the cells responsible for joint destruction in rheumatoid arthritis. Researchers found that CBD can reduce the viability of these ce…
inflammationfibroblastCannabinoidsrheumatoid arthritissynovia - A2019
Lymphatic pump manipulation in patients with chronic obstructive pulmonary disease
Bruno BordoniThis narrative review examines the use of lymphatic pump manipulation for patients with chronic obstructive pulmonary disease (COPD). COPD is characterized by persistent inflammation, and lymphatic techniques aim to red…
inflammationfasciaOsteopathicCOPDlymphatic pump - A2019
Role of matrix metalloproteinases 2 and 9 in the development of frozen shoulder: human data and experimental analysis in a rat contracture model
Chul-Hyun Cho, Yun-Mee Lho, Ilseon Hwang, Du Hwan KimThis study investigated the biological processes behind frozen shoulder, a condition characterized by pain and stiffness. Researchers analyzed joint capsule tissue from both patients with frozen shoulder and from a rat…
inflammationfibrosisfrozen shoulderimmobilizationrat; matrix metalloproteinases - A++2019
8 natural supplements to help fight inflammation
Zawn VillinesInflammation is a natural response to injury or infection, but when it becomes chronic, it can lead to long-term pain and tissue damage. This article reviews several natural supplements that may help the body manage chr…
inflammationomega-3curcumin - A++2019
Observation using thermography of post-operative reaction after fascial manipulation®
Joanna Fidut-Wrońska, Kamil Chołuj, Justyna Chmiel, Katarzyna Pikto-Pitkiewicz, Piotr MajcherThis study investigated whether Fascial Manipulation® causes a local increase in skin temperature, which is theorized to be part of its mechanism. Researchers used a thermal-imaging camera to measure skin temperature in…
inflammationFascial manipulationthermography - A2018
Neuroinflammation and central sensitization in chronic and widespread pain
Ru-Rong Ji, Andrea Nackley, Yul Huh, Niccolò Terrando, William MaixnerChronic pain is partly maintained by central sensitization, a state where the nervous system becomes hypersensitive. This review discusses how neuroinflammation—inflammation in the nervous system—contributes to this pro…
inflammationchronic paainneuroinflammationsensitization - B2017
Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis
Y Xiong, L Berrueta, K Urso, Sara Olenich, Igla Muskaj, G J Badger, A Aliprantis, R Lafyatis, H M LangevinThis animal study investigated the effects of stretching on systemic sclerosis, a condition that causes skin inflammation and fibrosis. Using a mouse model of the disease, researchers found that ten minutes of daily str…
inflammationfibrosisSystemic sclerosisStretchingscleroderma - B2017
All you need to know about the AIP diet
Lana BurgessThis article reviews the Autoimmune Protocol (AIP) diet, which aims to reduce inflammation and relieve symptoms of autoimmune disorders. The diet is based on the idea that problems with the gut wall, sometimes called 'l…
inflammationAutoimmune protocolautoimmune disease