Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesPrevalence of urinary and fecal incontinence and symptoms of genital prolapse in women
This questionnaire study investigated the links between urinary incontinence, fecal incontinence, and symptoms of genital prolapse in Swedish women. The researchers found that these three conditions often occur together…
Evidence of Connective Tissue Involvement in Acupuncture
Researchers investigated the "needle grasp" phenomenon in acupuncture, where it becomes harder to pull a needle out after manipulation. They hypothesized this is caused by connective tissue winding around the needle, ra…
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
During inflammation, components of our connective tissue like hyaluronic acid (HA) can break down. This study investigated how small fragments of HA affect the immune system. Researchers found that these fragments activ…
Age-related Changes in the Collagen Network and Toughness of Bone
This study investigated how the collagen network in bone tissue changes with age and how this affects bone toughness. Researchers analyzed 30 femurs from human cadavers, with donors ranging from 19 to 89 years of age. T…
Relationship of Acupuncture Points and Meridians to Connective Tissue Planes
Researchers investigated the hypothesis that the network of acupuncture points and meridians could represent the body's network of interstitial connective tissue. By mapping points in anatomical cross-sections of a huma…
Mammalian Hyaluronan Synthases
This 2002 review article describes the three enzymes that produce hyaluronan (HA) in mammals: HAS1, HAS2, and HAS3. These three enzyme isoforms have different characteristics and create different sizes of HA molecules.…
Effects of Biomechanical Stress on Bones in Animals
This animal study investigated how bones adapt to mechanical stress. The researchers found that cyclic loading, like in exercise, creates fluid flow within the bone that signals it to adapt. The rate of this loading is…
Detection of changes in cartilage water content using MRI T2-mapping in vivo
Early-stage osteoarthritis (OA) is characterized by an elevated water content in cartilage. This study investigated if a specific MRI technique, T2-mapping, could detect these changes in living subjects. Healthy volunte…
Adhesive capsulitis: role of MR imaging in differential diagnosis
This study investigated whether magnetic resonance imaging (MRI) can identify the changes typical of adhesive capsulitis (frozen shoulder). Researchers compared MRI scans from 24 patients with clinical evidence of froze…
Hyaluronan and its catabolic products in tissue injury and repair
This narrative review explores the role of hyaluronan (HA), a common component of connective tissue, in the body's response to injury. In healthy tissues, HA exists as a large molecule that helps maintain structural int…
Hyaluronan and Homeostasis: A Balancing Act
As only the title of this paper is available, it has not yet been summarized. The title suggests the article discusses the role of hyaluronan in maintaining homeostasis, the body's state of physiological balance. This i…
Collagen accumulation in muscles of children with cerebral palsy and correlation with severity of spasticity
This study investigated the link between connective tissue and muscle function in children with cerebral palsy (CP). Researchers analyzed muscle samples from 26 children, comparing collagen content to clinical measures…