Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2010
Hindlimb response to tactile stimulation of the pastern and coronet
H M Clayton, A D White, L J Kaiser, S Nauwelaerts, M Lavagnino, N C StubbsThis study investigated how lightweight tactile stimulators placed around horses' hind pasterns affect their movement patterns at a trot. Researchers found that the stimulation caused the horses to lift their hooves sig…
Rehabilitationphysiotherapytactile stimulationjoint motion - A++2010
Iron bioavailability and dietary reference values
Richard Hurrell, Ines EgliThis review discusses how the human body absorbs iron and how dietary reference values are determined. Since the body lacks a physiological mechanism to excrete excess iron, balance is maintained solely through intestin…
Iron uptake - A2010
The role and mechanical behavior of the connective tissue in tendon sliding
J-C Guimberteau, J-P Delage, J WongBased on 215 in-vivo dissections, this study challenges the traditional understanding of how tendons slide. The authors propose that tendon movement is not simple gliding, but rather occurs within a complex, adaptable c…
Tendon; Carpal sheath; Sliding system; Tendon vascularization; Finger flexor reconstruction; Collagenic fibrillar framework; Microvacuole - A++2010
In Vitro Modeling of Repetitive Motion Injury and Myofascial Release
Kate R Meltzer, Thanh V Cao, Joseph F Schad, Hollis King, Scott T Stoll, Paul R StandleyIn this laboratory study, researchers investigated how human connective tissue cells (fibroblasts) respond to simulated repetitive motion strain and myofascial release (MFR). They found that applying a repetitive strain…
Cyclic strain; Human fibroblasts; Morphology; myofascial release; repetitive motion strain - A+2010
The straight line hypothesis elaborated: Case reference obesity, an argument for acidosis, oxidative stress, and disease conglomeration
Shoma BerkemeyerThis review article brings together existing research to explain how obesity may be linked to oxidative stress. The author proposes that a proton imbalance, or acidosis, could be a key mechanism. This imbalance may inhi…
Oxidative stressobesityacidosisproton imbalance - A2010
Fluorescent Nanoparticles for Observing Primo Vascular System Along Sciatic Nerve
Zhao-Feng Jia, Byung-Cheon Lee, Ki-Hoon Eom, Jin-Myung Cha, Jin-Kyu Lee, Zhen-Dong Su, Wen-Hui Yu, Pan Dong Ryu, Kwang-…In this animal study, researchers injected fluorescent nanoparticles into rats at an acupuncture point to trace their path. The particles traveled along the sciatic nerve, revealing a previously hard-to-detect structure…
fasciaacupunctureSCIATIC NERVEprimo vascular systemprimo-vessel - A2010
Edema and fluid dynamics in connective tissue remodelling
Rolf K Reed, Åsa Lidén, Kristofer RubinThis review describes the role of loose connective tissues, focusing on fluid exchange across capillaries and the formation of edema (swelling). This process is relevant for conditions like inflammation, fibrosis (scarr…
inflammationLoose connective tissueConnective tissueheartEdema - A+2010
Tendon and ligament fibrillar crimps give rise to left-handed helices of collagen fibrils in both planar and helical crimps
Marco Franchi, Vittoria Ottani, Rita Stagni, Alessandro RuggeriTendons and ligaments have a wavy structure known as a "crimp," which straightens out as the tissue is stretched. This study on rat tissue used various microscopy techniques to examine the 3D shape of the individual col…
collagen handedness; fibrillar crimp; helical crimps; ligament; planar crimps; tendon - A2010
Comparison of Trunk Proprioception Between Patients With Low Back Pain and Healthy Controls
Angela S Lee, Jacek Cholewicki, Peter Reeves, Bohdanna T Zazulak, Lawrence W MysliwiecIn this case-control study, researchers compared trunk proprioception, or the sense of body position and movement, between 24 patients with non-specific low back pain and 24 healthy controls. Participants' ability to se…
Kinesthesis; Low back pain; Proprioception; Rehabilitation; Spine - C2010
A new lock-step mechanism of matrix remodelling based on subcellular contractile events
Lysianne Follonier Castella, Lara Buscemi, Charles Godbout, Jean-Jacques Meister, Boris HinzMyofibroblasts are cells that contribute to tissue contracture in fibrotic conditions like scarring. This study investigated how these cells contract to remodel tissue. The researchers identified two separate contractio…
fibrosiscollagenMyofibroblastCalcium oscillationsRho kinase - B2010
Mechanical Strain Stabilizes Reconstituted Collagen Fibrils against Enzymatic Degradation by Mammalian Collagenase Matrix Metalloproteinase 8 (MMP-8)
Brendan P Flynn, Amit P Bhole, Nima Saeidi, Melody Liles, Charles A DiMarzio, Jeffrey W RubertiThis laboratory study investigated how mechanical tension affects collagen's resistance to breakdown. Researchers created small networks of type I collagen fibers, gently stretching some while leaving others unloaded. B…
collagenstrainCollagenase - A2010
Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix
Rolf K Reed, Kristofer RubinThis narrative review discusses how the extracellular matrix (ECM) and the pressure of its fluid (interstitial fluid pressure, or Pif) regulate fluid exchange with capillaries. Conventionally, this pressure is seen as a…
inflammationConnective tissueglycosaminoglycansbeta-Integrin receptors