Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies

2,806

studies

602

top-graded

2,783

with plain-language summary

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Showing 925–936 of 957 studies · page 78/80Since 2010

A
2011
Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis
Carol A de la Motte
This narrative review explores the role of hyaluronan (HA) in intestinal health and disease. Chronic intestinal inflammation can lead to fibrosis, or scarring, a process driven by inflammatory signals and specialized ce…
hafasciaextracellular matrixfibrosismesenchymal cells
A
2011
Fibroblasts and Myofibroblasts: What are we talking about?
Jennifer Baum, Heather S Duffy
This 2011 narrative review explores the roles of fibroblasts and myofibroblasts, two key cell types in the heart's connective tissue. Once considered static, research indicates these cells are dynamic and play an active…
fasciafibroblastMyofibroblast
A
2011
Fibroblast cytoskeletal remodeling contributes to connective tissue tension
H M Langevin, N A Bouffard, J R Fox, B M Palmer, J Wu, J C Iatridis, W D Barnes, G J Badger, A K Howe
The mechanical properties of connective tissue, such as its elasticity and resistance, have traditionally been attributed to its non-cellular matrix. This study investigated the role of fibroblasts, the cells residing w…
fasciaConnective tissuefibroblastcytoskeletal remodeling
A
2011
The extracellular matrix: an active or passive player in fibrosis?
T N Wight, S Potter-Perigo
Fibrosis, the excessive buildup of scar tissue, can be understood as a wound healing process that has gone awry. Normally, specialized cells called myofibroblasts help repair tissue and then disappear, but in fibrosis,…
fasciaprovisional extracellular matrixmyofibroblatcollagenhyaluronan proteoglycans
A++
2011
Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments
Jennifer Z Paxton, Paul Hagerty, Jonathan J Andrick, Keith Baar
This study on engineered ligaments explored how different stretching patterns affect tissue development. Researchers used a bioreactor to apply cyclic stretch, measuring cellular responses by tracking a key protein call…
collagen synthesisERK 1/2 phosphorylationintermittent stretch
A+
2011
Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial
T E McAlindon, M Nuite, N Krishnan, R Ruthazer, L L Price, D Burstein, J Grif!th, K Flechsenhar
This pilot randomized controlled trial investigated if collagen hydrolysate supplements could affect knee cartilage in people with mild osteoarthritis. Using a specialized MRI technique (dGEMRIC), researchers tracked ch…
MRIosteoarthritisMagnetic resonance imagingCartilageDelayed gadolinium enhanced
A
2011
Hyaluronan: From Extracellular Glue to Pericellular Cue
B P Toole
Hyaluronan is traditionally seen as a biological 'goo' that lubricates joints and holds connective tissues together. This review describes how hyaluronan also functions as an important signaling molecule, or cue, in the…
hyaluronanfasciasignal transductioncancer
B
2011
The effect of molecular weight on hyaluronan’s cartilage boundary lubricating ability e alone and in combination with proteoglycan 4
J J Kwiecinski, S G Dorosz, T E Ludwig, S Abubacker, Mary K Cowman, T A Schmidt
This study investigated the lubricating ability of hyaluronan (HA) in articular cartilage, focusing on how its molecular weight affects function. Researchers found that higher molecular weight hyaluronan was more effect…
hyaluronanCartilage boundary lubricationProteoglycan 4 (PRG4)
B
2010
Force Transmission between Synergistic Skeletal Muscles through Connective Tissue Linkages
Huub Maas, Thomas G Sandercock
This review examines how force is transmitted between neighboring muscles through their shared connective tissue. Traditionally, muscles were seen as independent units pulling on bones via tendons, but emerging research…
Connective tissueForce transmissionepimuscular
B
2010
Detail microscopic analysis of deep fascia of lower limb and its surgical implication
Visweswar Bhattacharya, Partha Sarathi Barooah, Tapas Chandra Nag, Gaurab Ranjan Chaudhuri,, Siddhartha Bhattacharya
This study investigated the microscopic structure of the deep fascia in the lower limb, a tissue previously thought to be relatively simple and avascular. Researchers analyzed 50 tissue specimens using light, confocal,…
Confocal microscopydeep fasciaelectron microscopyflapmicroscopic anatomy
A
2010
Spontaneous and visible light-induced ultraweak photon emission from rat eyes
Chao Wanga, István Bókkonb, Jiapei Daia, István Antalc
In this in vitro study on rats, researchers found that isolated parts of the eye—the whole eye, lens, vitreous humor, and retina—emit extremely faint light, or photons. This photon emission occurred both spontaneously a…
fasciabioluminescent photonslipid peroxidationdiscrete dark noiseretinal phosphenes
1A+
2010
Tissue stretch induces nuclear remodeling in connective tissue fibroblasts
H M Langevin, K N Storch, R R Snapp, N A Bouffard, G J Badger, A K Howe, D J Taatjes
In a study on mice, researchers investigated how stretching connective tissue affects the nuclei of fibroblast cells. The results showed that when tissue samples were stretched for 30 minutes, the shape of the cell nucl…
Cytoskeleton; subcutaneous; nucleus; mechanotransduction; invagination