Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A++2011
Vibration therapy of the plantar fascia improves spasticity of the lower limbs of a patient with fetal-type Minamata disease in the chronic stage
Fusako Usuki, Satsuki TohyamaThis case report describes a treatment for spasticity in a patient with fetal-type Minamata disease. Researchers used a hand-held vibration massager applied directly to the patient's plantar fascia and hamstrings. After…
spasticityvibration therapy - A2011
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Thomas R Cox, Janine T ErlerIn this perspective article, the authors discuss how the extracellular matrix (ECM) is constantly being remodeled, a process essential for normal bodily functions like wound healing and tissue maintenance. When this rem…
fasciaextracellular matrixcancerfibrosisstiffness - A2011
Pandiculation: Nature’s way of maintaining the functional integrity of the myofascial system?
Luiz Fernando BertolucciThis paper explores the hypothesis that pandiculation—the involuntary stretching and yawning most animals do upon waking—serves a key role for the locomotor system. Beyond preparing the nervous system for wakefulness, t…
fasciaConnective tissuemyofasciayawningsleep-wake rhythm - A2011
Sensory Innervation of the Nonspecialized Connective Tissues in the Low Back of the Rat
Sarah M Corey, Margaret A Vizzard, Gary J Badger, Helene M LangevinIn this animal study, researchers investigated the sensory nerves in the nonspecialized connective tissue of the rat low back, an area where knowledge is limited. Using 3D reconstruction and dye-labeling techniques, the…
fasciaConnective tissueinnervationlow back painmusculoskeletal pain - A2011
Correlation of MR Arthrographic Findings and Range of Shoulder Motions in Patients With Frozen Shoulder
So-Yeon Lee, Jeongmi Park, Seok-Whan SongThis study investigated the relationship between findings on MR arthrography (a type of MRI) and range of motion in people with frozen shoulder. Researchers measured the thickness of two structures: the coracohumeral li…
MRIfrozen shoulderAdhesive capsulitiscoracohumeral ligament - A2011
Structure and function of the skeletal muscle extracellular matrix
Allison R Gillies, Richard L LieberThis narrative review explores the extracellular matrix (ECM), the connective tissue network within skeletal muscle. The authors describe the ECM's crucial roles in transmitting force and in muscle maintenance and repai…
Skeletal muscle; extracellular matrix; collagen; biomechanics; fibrosis - A2011
Management of the stiff shoulder. A prospective multicenter comparative study of the six main techniques in use: 235 cases
P Gleyzea, P Clavert, P-H Flurin, E Laprelle, D Katz, B Toussaint, T Benkalfate, C Charousset, T Joudet, T Georges, L H…This prospective study compared six different therapeutic techniques for stiff shoulder in 235 patients. Researchers evaluated conventional rehabilitation below the pain threshold against self-rehabilitation pushing pas…
frozen shoulderAdhesive capsulitisPain managementAlgodystrophyTherapeutic education - A2011
Sensory Innervation of the Thoracolumbar Fascia in Rats and Humans
J Tesarz, U Hoheisel, B Wiedenhöfer, S MenseThis study investigated the nerve supply of the thoracolumbar fascia (TLF), the connective tissue of the low back, in both rats and humans. Researchers found that the fascia is richly innervated with sensory nerves, but…
fasciaNociceptionThoracolumbar fascialow back painimmunohistochemistry - A2011
Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis
Carol A de la MotteThis narrative review explores the role of hyaluronan (HA) in intestinal health and disease. Chronic intestinal inflammation can lead to fibrosis, or scarring, a process driven by inflammatory signals and specialized ce…
hafasciaextracellular matrixfibrosismesenchymal cells - A2011
High and Low Molecular Weight Hyaluronic Acid Differentially Regulate Human Fibrocyte Differentiation
A S Maharjan, D Pilling, R H GomerFollowing tissue injury, immune cells called monocytes can differentiate into fibrocytes, a cell type involved in healing and fibrosis. This study investigated how different sizes of hyaluronic acid (HA) affect this pro…
hyaluronanfasciafibrocyte differentiationmonocyte - A2011
The Genetics of Vitamin C Loss in Vertebrates
Guy Drouin, Jean-Rémi Godin, Benoît PagéThis narrative review explores why some vertebrate species, including humans, cannot produce their own Vitamin C. The inability to synthesize this crucial nutrient, important for collagen and antioxidant functions, stem…
BiosynthesisVitamin CAscorbic acidGLO geneL-gulono-gamma-lactone oxidase - A2011
Exercise training reduces fibrosis and matrix metalloproteinase dysregulation in the aging rat heart
Hyo-Bum Kwak, Jong-hee Kim, Kumar Joshi, Alvin Yeh, Daniel A Martinez, John M LawlerIn this animal study, researchers investigated how exercise affects age-related fibrosis (scarring) in the rat heart. They found that aging was associated with an increase in collagen and a dysregulation of enzymes call…
collagenRemodelingTIMP-1
