Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2013
Metabolic control of hyaluronan synthases
Davide Vigetti, Manuela Viola, Evgenia Karousou, Giancarlo De Luca, Alberto PassiThis narrative review explores how a cell's energy and nutritional status regulate the production of hyaluronan (HA), a key component of the extracellular matrix. HA is synthesized by enzymes called HAS, which require s…
fasciaGlycosaminoglycanO-GlcNacylationUDP-GlcUAUDP-GlcNA - A+2013
Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies
Guo-Chong Chen, Da-Bing Lu, Zhi Pang, Qing-Fang LiuThis meta-analysis combined data from multiple prospective studies to investigate the link between vitamin C and stroke risk. The researchers found that people with higher dietary intake of vitamin C had a lower risk of…
antioxidants • diet • meta-analysis • prevention • stroke - A+++2013
Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection
Yejin Kim, Hyemin Kim, Seyeon Bae, Jiwon Choi, Sun Young Lim, Naeun Lee, Joo Myung Kong, Young-il Hwang, Jae Seung Kang…This animal study investigated how vitamin C affects the immune response to influenza A virus (H3N2). Researchers used mice that, like humans, cannot synthesize their own vitamin C. When these mice were made vitamin C-d…
immune responseVitamin Cantiviralinfluenza Ainterferon alfa/beta - A++2013
Implementation of Matrix Rhythm Therapy and Conventional Massage in Young Females and Comparison of Their Acute Effects on Circulation
Ferruh Taspinar, Ummuhan Bas Aslan, Nuran Sabir, Ugur CavlakThis randomized controlled trial compared the acute effects of Matrix Rhythm Therapy and conventional massage on lower leg blood circulation in young, healthy women. Fifteen participants received a single 30-minute sess…
fascia - A++2013
Vitamin C in Disease Prevention and Cure: An Overview
Shailja Chambial, Shailendra Dwivedi, Kamla Kant Shukla, Placheril J John, Praveen SharmaThis narrative review provides an overview of Vitamin C's many roles in the body. It is essential for developing and maintaining connective tissues, and plays a key part in bone formation, wound healing, and gum health.…
cancerdiabetesVitamin CImmunityinfertility - A2013
Heparan sulfate in the nucleus and its control of cellular functions
Mark D Stewart, Ralph D SandersonThis narrative review discusses the roles of heparan sulfate proteoglycans (HSPGs) inside the cell nucleus. These molecules are typically found on the cell surface and in the extracellular matrix, where they help regula…
ProteoglycanSyndecan-1Nuclear localizationChromatin modificationProliferation - B2013
Vitamin C further improves the protective effect of glucagon-like peptide-1 on acute hypoglycemia-induced oxidative stress, inflammation, and endothelial dysfunction in type 1 diabetes
ANTONIO CERIELLO, ANNA NOVIALS, EMILIO ORTEGA, SILVIA CANIVELL, LUCIA LA SALA, GEMMA PUJADAS, LOREDANA BUCCIARELLI, MAU…Acute low blood sugar (hypoglycemia) in people with type 1 diabetes can cause oxidative stress, inflammation, and damage to the lining of blood vessels. This study investigated whether the hormone GLP-1 and vitamin C co…
Oxidative stressdiabetesVitamin C - A2013
Primo Vascular System: Past, Present, and Future
Byung-Cheon Lee, Walter J Akers, Xianghong Jing, M Isabel Miguel Perez, Yeonhee RyuAs only the title of this article was available, this summary is necessarily limited. The title, "Primo Vascular System: Past, Present, and Future," suggests this is a review article. It likely covers the history of the…
fasciaprimo vascular systemeditorial - A++2013
Air ions and mood outcomes: a review and meta-analysis
Vanessa Perez, Dominik D Alexander, William H BaileyThis review and meta-analysis examined 33 studies to investigate how air ions affect human psychological states. The authors found no consistent effects of positive or negative ionization on anxiety, general mood, relax…
systematic reviewepidemiologyMood disordersDepressionAir ionization - A++2013
Vibration Induced Osteogenic Commitment of Mesenchymal Stem Cells is Enhanced by Cytoskeletal Remodeling but not Fluid Shear
Gunes Uzer, Suphannee Pongkitwitoon, M Ete Chan, Stefan JudexThis laboratory study investigated how mechanical vibrations encourage stem cells to develop into bone cells. Researchers tested two potential mechanisms: the force of fluid moving across the cells (fluid shear) and cha…
fasciaBonedifferentiationProliferationvibrations - A2013
Complete Obstetric Anal Sphincter Tear and Risk of Long-term Fecal Incontinence: A Cohort Study
Mette M Soerensen, Steen Buntzen, Karl M Bek, Søren LaurbergThis cohort study followed women for over 20 years to assess the long-term effects of complete anal sphincter tears during childbirth. Researchers compared 125 women who experienced such a tear with 238 women who gave b…
Anal sphincter injury; Fecal incontinence; Quality of life. - A++2013
Mathematical Analysis of the Flow of Hyaluronic Acid Around Fascia During Manual Therapy Motions
Max Roman, Hans Chaudhry, Bruce Bukiet, Antonio Stecco,Thomas FindleyThis study used a mathematical model to simulate how different manual therapy techniques affect the flow of hyaluronic acid (HA) within fascia. The researchers compared constant sliding, perpendicular vibration, and tan…
hyaluronanfasciaManual Therapyfluid flowvibration