Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2021
Fascia Focused Manual Therapy Interventions-Proposed Treatment for Post-COVID Syndrome
John SharkeyThis report proposes that fascia-focused manual therapies may be an appropriate treatment for patients with post-COVID syndrome. The author suggests that many of the long-term symptoms following COVID-19, such as soft t…
Coronavirus. Fascia. Post-COVID Syndrome. Long-term COVIDpost-COVID-19 syndrome. Hyaluronan. Angiotensin-converting enzyme 2 [ACE2]. Cytokines - A+++2021
Low frequency weak electric fields can induce structural changes in water
Iman Rad, Rainer Stahlberg, Kurt Kung, Gerald H PollackThis study investigated how weak, low-frequency electric fields affect the structure of different types of water, including "exclusion zone" (EZ) water. Researchers found that exposure to these fields, even without dire…
EZ waterfourth phase of water - A+++2021
Effect of vibration therapy on physical function in critically ill adults (VTICIA trial): protocol for a single-blinded randomised controlled trial
Nobuto Nakanishi, Satoshi Doi, Yoshimi Kawahara, Mie Shiraishi, Jun OtoThis is a protocol for a randomized controlled trial designed to investigate the effect of vibration therapy for critically ill adults. The researchers plan to enroll 188 intensive care unit (ICU) patients and randomly…
vibration therapydeliriummuscle atrophy - A+2021
Menopause, Ultraviolet Exposure, and Low Water Intake Potentially Interact with the Genetic Variants Related to Collagen Metabolism Involved in Skin Wrinkle Risk in Middle-Aged Women
Sunmin Park, Suna Kang, Woo Jae LeeThis observational study of 128 middle-aged women examined how genetic variants related to collagen metabolism interact with lifestyle factors to influence wrinkle development. Researchers found that women with a high p…
COL17A1; EGFR; MMP16; UV exposure; genetic variants; wrinkle. - A+++2021
Cannabinoids in the landscape of cancer
Nagina Mangal, Simon Erridge, Nagy Habib, Anguraj Sadanandam, Vikash Reebye, Mikael Hans SodergrenThis narrative review explores how cannabinoids—including plant-derived, endogenous, and synthetic versions—interact with cancer in laboratory and animal models. The research suggests that these compounds may inhibit tu…
Cancer; Cannabidiol; Cannabinoid receptors; Cannabinoids; Endocannabinoid system; Tetrahydrocannabinol - A+++2021
Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin
Edwin D Lephart, Frederick NaftolinThis narrative review explores how the decline in estrogen levels during menopause significantly impacts skin health and structural integrity. The loss of estrogen leads to reduced collagen and elastin production, along…
4′-Acetoxy resveratrol; Aging; Cosmeceuticals; Equol; Estrogen; Estrogen deficient skin; Hormone therapy; Menopause; Polyphenols; Skin - A+++2021
Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity
Nicholas V DiPatrizioThis narrative review explores how the endocannabinoid system in the upper gastrointestinal tract regulates gut-brain communication to control food intake and energy balance. Research suggests that these lipid-derived s…
CB1 receptor; endocannabinoid; food intake; gut-brain; intestine; reward - A+++2021
Soft Tissue Manipulation May Attenuate Inflammation, Modulate Pain, and Improve Gait in Conscious Rodents With Induced Low Back Pain
M Terry Loghmani, Carolyn Tobin, Colleen Quigley, Alanna FennimoreThis animal study on rodents explored how instrument-assisted soft tissue manipulation (IASTM) affects pain, gait, and inflammation in cases of low back pain. The researchers found that the treatment suggests an ability…
rehabilitation - A+2021
Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19
Yun Kit Yeoh, Tao Zuo, Grace Chung-Yan Lui, Fen Zhang, Qin Liu, Amy Y L Li, Arthur C K Chung, Chun Pan Cheung, Eugene Y…Researchers investigated the link between the gut microbiome and the severity of COVID-19. In this cohort study, they analyzed stool and blood samples from 100 patients and compared them to individuals without COVID-19.…
colonic bacteria; colonic microflora; inflammation - A+++2021
Fascial thickness and stiffness in hypermobile Ehlers-Danlos syndrome
Tina J Wang, Antonio SteccoResearchers investigated fascial changes in people with hypermobile Ehlers-Danlos Syndrome (hEDS), a condition often associated with widespread pain. They used ultrasound and elastography to compare fascial thickness an…
deep fasciaconnective tissue disorderhypermobile Ehlers-Danlos syndromeultrasound elastography - A+++2021
The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self
Wen G Chen, Dana Schloesser, Angela M Arensdorf, Janine M Simmons, Changhai Cui, Rita Valentino, James W Gnadt, Lisbeth…This review article presents a unified framework for interoception, the process by which the body senses, interprets, and regulates its internal signals. The authors propose an expanded definition that includes bidirect…
autonomic; insula; parasympathetic; spinal; sympathetic; vagal - A+++2021
Variant connective tissue (joint hypermobility) and dysautonomia are associated with multimorbidity at the intersection between physical and psychological health
Jenny L L Csecs, Nicholas G Dowell, Georgia K Savage, Valeria Iodice, Christopher J Mathias, Hugo D Critchley, Jessica…This study investigated the links between joint hypermobility, autonomic nervous system dysfunction (dysautonomia), and anxiety in adults with mental health or neurodevelopmental conditions. Researchers found that this…
joint hypermobilityAnxietyautonomic dysfunctionmultimorbidity