Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- C2013
Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass
Jos Malda, Janny C de Grauw, Kim E M Benders, Marja J L Kik, Chris H A van de Lest, Laura B Creemers, Wouter J A Dhert,…This study investigated how articular cartilage adapts to body size across different mammals. Researchers analyzed cartilage from the knee joints of 58 species, ranging from mice to elephants. They found that while cart…
fasciamammalsarticular cartilagetissue ticknessosteochondral cores - A2013
Metabolic control of hyaluronan synthases
Davide Vigetti, Manuela Viola, Evgenia Karousou, Giancarlo De Luca, Alberto PassiThis narrative review explores how a cell's energy and nutritional status regulate the production of hyaluronan (HA), a key component of the extracellular matrix. HA is synthesized by enzymes called HAS, which require s…
fasciaGlycosaminoglycanO-GlcNacylationUDP-GlcUAUDP-GlcNA - C2013
What Lies Beneath: Sub-Articular Long Bone Shape Scaling in Eutherian Mammals and Saurischian Dinosaurs Suggests Different Locomotor Adaptations for Gigantism
Matthew F Bonnan, D Ray Wilhite, Simon L Masters, Adam M Yates, Christine K Gardner, Adam AguiarThis study explored why giant dinosaurs were more common than giant mammals by examining their joint structures. Researchers compared the long bones of large mammals like elephants and rhinos with those of saurischian d…
fasciaeutherian mammalsdinosaursherbivoresgiant mammals - A2013
Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective
Lisa D Muiznieks, Fred W KeeleyThis review article examines the extracellular matrix (ECM), the dynamic network of molecules surrounding our cells. The authors focus on fibrous proteins like collagen and elastin, which form the structural backbone of…
fasciaextracellular matrixcollageneastinself-assembly - A+2013
Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation?
N Arngrim, L Simonsen, J J Holst, J BülowResearchers compared lymphatic drainage from abdominal fat tissue in lean and obese men. They measured drainage before and after the men consumed a glucose drink, which mimics the body's response to a meal. In lean men,…
adipose tissue; lymphatic drainage; blood flow; glucose load; obesity; diabetes - A++2013
Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin-C deficient mice
John Cha, M Waheed Roomi, Vadim Ivanov, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias RathThis animal study investigated how Vitamin C (ascorbate) supplementation affects cancer growth in mice that, like humans, cannot produce their own. Researchers injected melanoma or breast cancer cells into two groups of…
Tumor growthinterleukin-6apoptosismetastasisascorbate - A2013
Earthing (Grounding) the Human Body Reduces Blood Viscosity—a Major Factor in Cardiovascular Disease
Gaétan Chevalier, Stephen T Sinatra, James L Oschman, Richard M DelanyThis small study investigated how direct physical contact with the earth, known as 'grounding' or 'earthing', affects blood properties. Ten healthy participants were grounded for two hours using conductive patches on th…
fasciaearthinggroundingearth surface electronscardiovasclar disease - A2013
Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts
Nanna Goldman, Devin Chandler-Militello, Helene Langevin, Maiken Nedergaard, Takahiro TakanoThis laboratory study investigated how certain molecules, called purines, affect human fibroblast cells. Previous research has shown that acupuncture can trigger the release of purines like ATP. The researchers exposed…
fasciacytoskeletonacupunctureFibroblastscalcium signaling - A2013
A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C
Anitra C Carr, Stephanie M Bozonet, Juliet M Pullar, Jeremy W Simcock, Margreet C M VissersThis randomized study investigated whether the body absorbs vitamin C from kiwifruit as effectively as from a synthetic supplement. Thirty-six young men received either half a kiwifruit or an equivalent dose (50 mg) vit…
ascorbate; ascorbic acid; human; plasma; urine; semen; leukocytes; skeletal muscle - A++2013
Cell-to-cell signaling through light: just a ghost of chance?
Ondřej Kučera, Michal CifraThis paper examines the physical feasibility of cell-to-cell communication via weak light signals, often referred to as biophotons. The researchers analyze whether electromagnetic signaling is possible when considering…
Cell signalingbiophotonsphoton emission - B2013
The resolution of inflammation
Christopher D Buckley, Derek W Gilroy, Charles N Serhan, Brigitta Stockinger, Paul P TakThis article summarizes a discussion from a scientific conference on how to turn off undesirable inflammation. There is a growing appreciation that the resolution of inflammation, much like its initiation, is an active…
inflammationresolution - A2013
Training principles for fascial connective tissues: Scientific foundation and suggested practical applications
Robert Schleip, Divo Gitta MüllerConventional sports training often emphasizes muscles, cardiovascular conditioning, and coordination, yet most overload injuries occur within the body's connective tissue network, or fascia. This review article proposes…
fasciaStretchingfascial netCollagen renewalelastic recoil