Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2014
Specific Sizes of Hyaluronan Oligosaccharides Stimulate Fibroblast Migration and Excisional Wound Repair
C Tolg, P Telmer, E TurleyHyaluronan (HA) is a molecule important for wound healing, and its effects appear to depend on its size. In this study using cell cultures and animal models, researchers investigated how specific, small fragments of HA…
fasciahyaluronan molecular sizehyaluronan fragmentswound healing - A2014
Ultrasound Elastography: The New Frontier in Direct Measurement of Muscle Stiffness
Joline E Brandenburg, Sarah F Eby, Pengfei Song, Heng Zhao, Jeffrey S Brault, Shigao Chen, Kai-Nan AnThis 2014 review article describes ultrasound elastography, a technology that can directly measure the mechanical properties of tissue, such as muscle stiffness. The authors suggest that its real-time measurements can a…
musclesElastographydiagnostic imagingelasticityhardness - A+2014
The theory and fundamentals of bioimpedance analysis in clinical status monitoring and diagnosis of diseases
Sami F Khalil, Mas S Mohktar, Fatimah IbrahimBioimpedance analysis is a noninvasive, low cost and a commonly used approach for body composition measurements and assessment of clinical condition. There are a variety of methods applied for interpretation of measured…
bioimpedance analysis; body composition; clinical status monitoring; diseases diagnostic and prediction - A2014
Deformations Experienced in the Human Skin, Adipose Tissue, and Fascia in Osteopathic Manipulative Medicine
Hans Chaudhry, Bruce Bukiet, Zhiming Ji, Antonio Stecco, Thomas W FindleyThis study used a mathematical model to investigate how forces from manual therapy affect the skin, adipose tissue, and fascia. The researchers aimed to understand how much each layer deforms under compression and shear…
fasciaosteopathyManual Therapy - A+++2014
Telocytes revisited
Sanda M Cretoiu, Laurentiu M PopescuThis narrative review summarizes findings on telocytes, a relatively new type of cell found in the interstitial, or connective, tissue of many organs. These cells are defined by their small bodies and extremely long, th…
exosomes/ectosomes; intercellular signaling; regenerative medicine; telocytes; telopodes - A2014
Antioxidants in health and disease
E Ginter, V Simko, V PanakovaThis narrative review summarizes research on antioxidants published since 2010. The main role of antioxidants is to neutralize reactive oxygen species (ROS), which are linked to conditions like cardiovascular disease, c…
antioxidantsreactive oxygen species (ROS)vitamin C and Ecarotenoidspolyphenols - A2014
Chiropractic Management of Pubic Symphysis Shear Dysfunction in a Patient With Overactive Bladder
Robert Cooperstein, Anthony Lisi, Andrew BurdThis case report describes the chiropractic care of a 24-year-old woman with an overactive bladder, specifically frequent nighttime urination that disrupted her sleep. A physical examination revealed a shear dysfunction…
fasciasymphysis pubis dysfunctionpubic symphysispubic symphysis diastasisurinary bladder overactive - A2014
Clinical and symptomatological reflections: the fascial system
Bruno Bordoni, Emiliano ZanierThis narrative review discusses the fascial system as a continuous network of connective tissue that gives form and function to the entire body. The authors note that despite its importance in transmitting force, coordi…
fasciapainlow back painOsteopathicneck - C2014
Monocyte chemoattractant protein-1-induced excitation and sensitization to mechanical stimulation of mechanosensitive C-fiber afferents in rat skin
Asako Kubo, Toru Taguchi, Kazue MizumuraIn this animal study, researchers investigated the effects of the protein MCP-1, which is involved in inflammation, on nerve endings in the skin. Using skin-nerve preparations from rats, they found that applying MCP-1 d…
MCP-1CCL2Single fiber recordingUnmyelinated afferentsMechanical sensitization - B2014
Altered Gene Transcription in Human Cells Treated with Ludox® Silica Nanoparticles
Caterina Fede, Caterina Millino, Beniamina Pacchioni, Barbara Celegato, Chiara Compagnin, Paolo Martini, Francesco Selv…This in vitro study investigated how human lung cells react to exposure to Ludox® silica nanoparticles, which are common in industrial and biomedical applications. Using genetic analysis, researchers observed that the c…
nanoparticles (NPs); cell toxicity; microarray gene expression; pathway analysis - B2014
Neuroreceptor Activation by Vibration-Assisted Tunneling
Ross D Hoehn, David Nichols, Hartmut Neven, Sabre KaisThis theoretical study used quantum chemical modeling to explore how receptors in the nervous system get activated. The researchers propose a model where a molecule's specific vibrations, like a musical key, may be what…
fasciag-proteinpharmacologyGPCRssilicopotency - A+2014
Dietary Hyaluronic Acid Migrates into the Skin of Rats
Mariko Oe, Koichi Mitsugi, Wataru Odanaka, Hideto Yoshida, Ryosuke Matsuoka, Satoshi Seino, Tomoyuki Kanemitsu, Yasunob…In this animal study, researchers investigated whether orally ingested hyaluronic acid could reach the skin in rats. Using a radio-labeled version of hyaluronic acid, they tracked its path through the body after rats we…
Orally HAHA supplement