Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2015
Cellulite treatment: a comprehensive literature review
Irene Zerini, Andrea Sisti, Roberto Cuomo, Serena Ciappi, Francesco Russo, Cesare Brandi, Carlo D’Aniello, Giuseppe NisiIn this 2015 literature review, researchers compiled the results from various cellulite treatments. They analyzed 73 clinical studies involving human subjects, most of whom were women. The evaluated treatments included…
elasticitycellulitefatty tissue - A+2015
Chondroprotection and the Prevention of Osteoarthritis Progression of the Knee
Brian Gallagher, Fotios P Tjoumakaris, Marc I Harwood, Robert P Good, Michael G Ciccotti, Kevin B FreedmanIn this systematic review, researchers evaluated whether certain medications and supplements could protect joint cartilage and slow the progression of knee osteoarthritis. By analyzing randomized controlled trials, they…
knee; articular cartilage; chondroprotection; nutraceutical - A++2014
New perspective in cell communication: Potential role of ultra-weak photon emission
Ankush Prasad, Claudio Rossi, Stefania Lamponi, Pavel Pospíšil, Alberto FolettiThis 2014 narrative review explores how cells might communicate with each other. Beyond chemical signals and direct contact, the authors discuss evidence for communication via electromagnetic radiation, specifically ult…
fasciabiophotonsUltra-weak photon emissioncellular interactionbiocommunication - A++2014
Role of reactive oxygen species in ultra-weak photon emission in biological systems
Pavel Pospíšil, Ankush Prasad, Marek RácThis narrative review explores the connection between reactive oxygen species (ROS) and the faint light, or ultra-weak photon emission, that living organisms naturally produce. The authors explain that normal metabolic…
biophotonsChemiluminescenceReactive oxygen specieslipid peroxidationHydroxyl radical - A2014
Lumbopelvic muscle activation patterns in three stances under graded loading conditions: Proposing a tensegrity model for load transfer through the sacroiliac joints
Hamed Pardehshenas, Nader Maroufi, Mohammad Ali Sanjari, Mohamad Parnianpour, Stephen M LevinResearchers investigated how lumbopelvic muscles activate to stabilize the sacroiliac (SI) joints under different loads. They compared muscle activity in 30 men during two-legged and one-legged standing while holding we…
fasciasacroiliac jointload transferwire-spoke wheel modelarch theory; Self-bracing - C2014
Monocyte chemoattractant protein-1-induced excitation and sensitization to mechanical stimulation of mechanosensitive C-fiber afferents in rat skin
Asako Kubo, Toru Taguchi, Kazue MizumuraIn this animal study, researchers investigated the effects of the protein MCP-1, which is involved in inflammation, on nerve endings in the skin. Using skin-nerve preparations from rats, they found that applying MCP-1 d…
MCP-1CCL2Single fiber recordingUnmyelinated afferentsMechanical sensitization - A2014
Skin, fascias, and scars: symptoms and systemic connections
Bruno Bordoni, Emiliano ZanierThis review article explores how skin, fascia, and scars are interconnected and can affect the entire body. The authors describe the skin as an organ that communicates with the nervous system and other structures. When…
fasciaOsteopathicSkinscarringscar - A++2014
Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products
Alfonso Gautieri, Alberto Redaelli, Markus J Buehler, Simone VesentiniAdvanced Glycation End-products (AGEs) are harmful crosslinks that form in collagen with aging and in diabetes, making tissues stiffer. However, the exact location of these crosslinks has been unclear. In this theoretic…
Advanced glycation end-products; Ageing; Atomistic simulations; Collagen; Crosslinks; Diabetes. - A++2014
Ultra-weak photon emission from biological samples: Definition, mechanisms, properties, detection and applications
Michal Cifra, Pavel PospíšilThis review article summarizes the current understanding of ultra-weak photon emission (UPE), a faint light naturally produced by living organisms. This light, a form of chemiluminescence, is generated during normal met…
biophotonsChemiluminescenceOxidative stressSinglet oxygenCharge coupled device - A+++2014
Telocytes revisited
Sanda M Cretoiu, Laurentiu M PopescuThis narrative review summarizes findings on telocytes, a relatively new type of cell found in the interstitial, or connective, tissue of many organs. These cells are defined by their small bodies and extremely long, th…
exosomes/ectosomes; intercellular signaling; regenerative medicine; telocytes; telopodes - B2014
Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation
Christopher D Buckley, Derek W Gilroy, Charles N SerhanIn this narrative review, the authors explain that the resolution of inflammation is an active, carefully orchestrated process, not just the passive stopping of an inflammatory response. Specific molecules called specia…
acute inflammationpro-resolving mediators - A+++2014
The active role of vitamin C in mammalian iron metabolism: much more than just enhanced iron absorption!
Darius J R Lane, Des R RichardsonThis review explores how vitamin C (ascorbate) plays a sophisticated role in mammalian iron metabolism beyond simply enhancing absorption in the gut. Evidence suggests that vitamin C regulates how cells take up, store,…
Ascorbate; Dcytb; Ferritin; Free radicals; HIF; IRP; Iron; Transferrin; Vitamin C