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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 721–732 of 957 studies · page 61/80Since 2010
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  1. B
    2015

    Manual therapies and hypoalgesia: What are the mechanisms?

    Leon Chaitow

    This is a title-only entry, and its contents have not yet been summarized. The title suggests the article explores the possible mechanisms behind hypoalgesia, or a decreased sensitivity to pain, following manual therapi…

    Editorial
  2. C
    2015

    Hyaluronic acid and wound healing

    M G Neuman, R M Nanau, L Oruna-Sanchez, G Coto

    In this systematic review, researchers compiled studies on hyaluronic acid (HA) and wound healing published from 2010–2014. The review found that HA is used for tissue regeneration, either alone or in combination with o…

    hyaluronanwound healing
  3. B
    2015

    Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation

    Sami Albeiroti, Katayoun Ayasoufi, [...], Carol A de la Motte

    Platelets play a key role in responding to tissue injury. This study explores how they interact with hyaluronan, a major component of the extracellular matrix that is involved in inflammation. Researchers demonstrated t…

    hyaluronanextracellular matrixDegradationhyaluronidas-2HYAL2
  4. A++
    2015

    BioTensegrity Fascia and the fallacy of biomechanics. Part 1

    John Sharkey

    This conceptual article introduces Biotensegrity as an emerging model for understanding human anatomy. It challenges traditional biomechanics by viewing the body as a continuous tensional network in which fascia plays a…

    biotensegrityBiomechanics
  5. A
    2015

    Primo-Vascular System as Presented by Bong Han Kim

    Vitaly Vodyanoy, Oleg Pustovyy, Ludmila Globa, Iryna Sorokulova

    In the 1960s, researcher Bong Han Kim described a new vascular system, distinct from the blood and lymph systems, which he proposed was involved in tissue regeneration. However, his work was difficult for later scientis…

    fasciaprimo vascular system
  6. 1A+
    2015

    Fascia and Primo Vascular System

    Chun Yang, Yi-kuan Du, Jian-bin Wu, JunWang, Ping Luan, Qin-lao Yang, Lin Yuan

    In this review article, the authors explore the idea that the body's network of fascia may be the physical structure corresponding to acupuncture meridians in Traditional Chinese Medicine (TCM). They also discuss the pr…

    fasciamechanotransductionprimo vascular systemBonghan systemfasciology
  7. B
    2015

    Hyaluronan Regulates Bone Morphogenetic Protein-7- dependent Prevention and Reversal of Myofibroblast Phenotype

    Adam C Midgley, Lucy Duggal, Robert Jenkins, Vincent Hascall, Robert Steadman, Aled O Phillips, Soma Meran

    This study on human lung fibroblasts investigated how a protein called BMP7 might counteract fibrosis. Researchers found that BMP7 can prevent and even reverse the formation of myofibroblasts, which are cells that contr…

    hyaluronanMyofibroblastTGF-beta1
  8. 1A+++
    2015

    Viscoelastic Properties of Hyaluronan in Physiological Conditions

    Mary K Cowman, Tannin A Schmidt, Preeti Raghavan, Antonio Stecco

    Hyaluronan (HA) is a molecule that gives the fluid in our connective tissues its viscous, gel-like quality. This viscosity is crucial for the smooth gliding of fascial layers against muscles and other tissues. Factors l…

    Hyalyronian acidhaviscositylubricationviscoelasticity
  9. B
    2015

    Fibromyalgia: A Critical and Comprehensive Review

    Andrea T Borchers, M Eric Gershwin

    This comprehensive review discusses fibromyalgia as a complex disorder within a spectrum of medically unexplained syndromes. Characterized by widespread pain, fatigue, and sleep disturbances, it is often associated with…

    FibromyalgiaChronicpainOpiatesPatient supportTrauma
  10. A
    2015

    Hyaluronan, inflammation and breast cancer progression

    Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthy

    This narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…

    hyaluronaninflammationCD44fasciaBreast cancer
  11. A
    2015

    Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review

    Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María Cruz Pérez-Yus, Marcelo M P Demarzo, Mauro García-Toro, J…

    This systematic review examined how non-drug treatments affect inflammatory markers in people with fibromyalgia. Researchers analyzed 12 studies involving 536 participants who underwent exercise, dietary, or multidiscip…

    fasciaFibromyalgiapaincytokinessleep quality
  12. A
    2015

    Modeled Osteopathic Manipulative Treatments: A Review of Their in Vitro Effects on Fibroblast Tissue Preparations

    Manal Zein-Hammoud, Paul R Standley

    This narrative review summarizes lab-based (in vitro) studies investigating how simulated osteopathic treatments, like myofascial release, affect fibroblasts. The authors found that applying mechanical strain to these c…

    fasciaFibroblastsManual TherapyOsteopathic