Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+2015
An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing
Teresa Figueres Juher, Esther Basés PérezThis narrative review summarizes research on hydrolysed collagen (HC) and its impact on joint, bone, and skin health. Evidence suggests that these small collagen peptides are highly bioavailable and accumulate in connec…
supplementationOsteoporosishydrolysate collagenosteartrithis - A2015
The fascial system and exercise intolerance in patients with chronic heart failure: hypothesis of osteopathic treatment
Bruno Bordoni, F MarelliThis hypothesis paper proposes a connection between the fascial system and exercise intolerance in people with chronic heart failure. The authors note that heart failure is a complex disease affecting the entire body, l…
fasciaManual TherapyOsteopathicfatiguechronic heart failure - A2015
Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels
Sanda Maria Cretoiu, Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Dragos Cretoiu, Laura Cristina Ceafala…Telocytes are a relatively newly described cell type found in the muscular wall of the uterus, thought to play a role in cell-to-cell signaling. In this laboratory study, researchers examined telocytes from both pregnan…
Telocytes · Human myometrium · T-type calcium channels · CaV3.1 · CaV3.2 - A2015
Evidence for the existence of nociceptors in rat thoracolumbar fascia
S Mense, U HoheiselThis animal study on rats investigated the presence of pain-sensing nerve fibers (nociceptors) in the thoracolumbar fascia. Researchers compared normal fascia with tissue in which they had induced inflammation. The resu…
inflammationfasciafasciitisnon-specific low back painfascia nociceptors - A2015
A multidisciplinary approach to scars: a narrative review
Emiliano Zanier, Bruno BordoniThis narrative review examines complementary and alternative medicine approaches to treating scar tissue. The authors survey literature on osteopathy, naturopathy, and manual therapies like physiotherapy. They also disc…
fasciaosteopathyscarwoundcomplementary and alternative medicine - A++2015
Influence of different intensities of vibration on proliferation and differentiation of human periodontal ligament stem cells
Chunxiang Zhang, Yanqin Lu, Linkun Zhang, Yang Liu, Yi Zhou, Yangxi Chen, Haiyang YuIn this laboratory study, researchers investigated how low-magnitude, high-frequency vibration affects stem cells from the human periodontal ligament, the tissue that holds teeth in the jaw. The results suggest that vib…
Proliferationmechanical vibrationperiodontal ligament stem cellsosteogenesismagnitude - A++2015
The Effects of Vibration and Muscle Fatigue on Trunk Sensorimotor Control in Low Back Pain Patients
Jean-Alexandre Boucher, Jacques Abboud, François Nougarou, Martin C Normand, Martin DescarreauxThis study compared trunk muscle control between people with chronic low back pain (cLBP) and healthy individuals. Researchers found that the cLBP group was less accurate at reproducing a specific amount of force with t…
fascialow back painmuscle fatiguevibration - A2015
Innervation Changes Induced by Inflammation of the Thoracolumbar Fascia
U Hoheisel, J Rosner, S MenseThis animal study investigated how inflammation affects the nerves in the thoracolumbar fascia (TLF) of rats. Researchers induced inflammation in the TLF and compared its nerve fiber density to that of healthy fascia. W…
inflammationfasciafasciitisfascia innervationsympathetic fibers - A2015
Modes of cancer cell invasion and the role of the microenvironment
Andrew G Clark, Danijela Matic VignjevicFor cancer to spread, or metastasize, tumor cells must first invade the surrounding connective tissue (stroma). This review article describes how cancer cells can move in different ways—either as single cells or in coll…
fasciaextracellular matrixcancertumor invasionmicroenvironment - B2015
Transforming Growth Factor-beta1 (TGF-beta1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts
Adam C Midgley, Mathew Rogers, Maurice B Hallett, Aled Clayton, Timothy Bowen, Aled O Phillips, Robert SteadmanThe transformation of fibroblasts into myofibroblasts is a key part of wound healing, a process largely regulated by the signaling molecule TGF-β1. This study investigated how hyaluronan (HA) and specific receptors (CD4…
CD44; Epidermal Growth Factor Receptor (EGFR); Hyaluronate; Lipid Raft; Myofibroblast - A2015
Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?
S Albeiroti, A Soroosh, C A de la MotteThis 2015 review article explores the role of hyaluronan (HA) in fibrosis, a condition where excessive connective tissue buildup impairs organ function. HA is a key component of the extracellular matrix, known for its h…
hyaluronanfasciafibrosis - A2015
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
Agata A Mossakowski, Julian Pohlan, Daniel Bremer, Randall Lindquist, Jason M Millward, Markus Bock, Karolin Pollok, Ro…In this animal study, researchers used a mouse model for multiple sclerosis (MS) to track the sources of oxidative stress in the central nervous system. Using an advanced imaging technique, they identified specific immu…
Multiple sclerosis · Oxidative stress · Neuronal dysfunction · Fluorescence lifetime microscopy · Intravital imaging · Oxidative stress memory