Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A++2017
Massage therapy research review
Tiffany FieldThis review summarizes research showing beneficial effects of massage therapy for a wide range of conditions, including prenatal depression, pain syndromes, autoimmune conditions, and issues related to aging. The author…
Massage therapy research review - A2017
Effect of MELT method on thoracolumbar connective tissue: The full study
Faria Sanjana, Hans Chaudhry, Thomas FindleyThis study investigated if the MELT method, a self-treatment technique using soft rollers and balls, could affect the thoracolumbar connective tissue in people with chronic low back pain. Researchers used ultrasound ima…
Low back pain; MELT method; Connective tissue; Thickness; Myofascia; Flexibility - A++2017
Interaction between the gut microbiome and mucosal immune system
Na Shi, Na Li, Xinwang Duan, Haitao NiuIn this narrative review, the authors outline the two-way relationship between the gut microbiome and the mucosal immune system. A balanced microbiome is essential for the proper maturation and function of the immune sy…
inflammationMicrobiomeImmunity - A+++2017
Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase
Hai-Tao Zhang, Zi-Jian Zhang, Wei-Chuan Mo, Ping-Dong Hu, Hai-Min Ding, Ying Liu, Qian Hua, Rong-Qiao HeThis study investigates how an extremely weak magnetic field, similar to conditions in outer space or shielded environments on Earth, affects human cells. Researchers found that shielding the natural geomagnetic field r…
hydrogen peroxide; hypomagnetic field; oxidative stress; reactive oxygen species; superoxide dismutase - A+++2017
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J…This randomized controlled trial examined the effects of a fasting-mimicking diet (FMD) on risk factors for age-related diseases in 100 healthy participants. For five consecutive days each month over a three-month perio…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; cancer; diabetes; cardiovascular disease - A2017
Amino acid composition in determination of collagen origin and assessment of physical factors effects
Marlena Gauza-Włodarczyk, Leszek Kubisz, Dariusz WłodarczykThis study examines the amino acid composition of collagen derived from various sources, including fish skin, bovine Achilles tendon, and bone tissue. The researchers found that the levels of hydroxyproline, a unique am…
hydroxyprolineBone collagenFish skin collagenIrradiationPolymer - A+++2017
Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation
Benoit Chassaing, Tom Van de Wiele, Jana De Bodt, Massimo Marzorati, Andrew T GewirtzThis study investigated how common food additives, specifically the emulsifiers polysorbate 80 (P80) and carboxymethylcellulose (CMC), affect the gut microbiota. Using a laboratory model of the human intestinal ecosyste…
INFLAMMATION; INTESTINAL MICROBIOLOGY - A+++2017
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Chia-Wei Cheng, Valentina Villani, Roberta Buono, Min Wei, Sanjeev Kumar, Omer H Yilmaz, Pinchas Cohen, Julie B Sneddon…This study, involving mice and human pancreatic cells, explores how cycles of a fasting-mimicking diet (FMD) may influence the pancreas's ability to produce insulin. Researchers found that the diet appears to activate g…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; diabetes - A++2017
NAD and the aging process: Role in life, death and everything in between
Claudia C S Chini, Mariana G Tarragó, Eduardo N ChiniThis narrative review explores the vital role of the molecule NAD in cellular health and the aging process. Beyond its traditional role in metabolism, NAD is essential for cell signaling and regulating the epigenetic st…
Aging; CD38; Mitochondrial function; NAD(+); PARP; SIRTUINS - A+2016
Piezo2 is the principal mechanotransduction channel for proprioception
Seung-Hyun Woo, Viktor Lukacs, Joriene C de Nooij, Dasha Zaytseva, Connor R Criddle, Allain Francisco, Thomas M Jessell…Proprioception is the sense of where our body parts are in space. In this animal study, researchers investigated the molecular sensor responsible for this ability in mice. They found that an ion channel called Piezo2 wa…
proprioceptionmuscle spindlespiezomechanotranductiiongolgi tendon organ - A+++2016
Fascial Manipulation® for chronic aspecific low back pain: a single blinded randomized controlledtrial.
Mirco Branchini, Francesca Lopopolo, Ernesto Andreoli, Ivano Loreti, Aurélie M Marchand, Antonio SteccoThis randomized controlled trial compared Fascial Manipulation® combined with standard physiotherapy to physiotherapy alone for patients with chronic non-specific low back pain. The group receiving Fascial Manipulation®…
hyaluronanBack PainFascial manipulation - A2016
Human Recombinant Hyaluronidase Injections For Upper Limb Muscle Stiffness in Individuals With Cerebral Injury: A Case Series
Preeti Raghavan, Ying Lu, Mona Mirchandani, Antonio SteccoThis case series investigated injections of the enzyme hyaluronidase to treat upper limb muscle stiffness in 20 individuals with cerebral injury. The researchers hypothesized that an accumulation of hyaluronan in the mu…
fasciaConnective tissueStrokeHypertoniaspasticity