Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2017
Resveratrol regulates body weight in healthy and ovariectomized rats
Rupali Sharma, Neel Kamal Sharma, M ThungapathraThis animal study on rats investigated how the plant compound resveratrol affects body weight in both healthy subjects and those who had undergone ovariectomy, a model for menopause. The results suggest that resveratrol…
OVX; Ovariectomy; Resveratrol; Soya free diet - A2017
Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles
Uma Thanigai Arasu, Riikka Kärnä, Kai Härkönen, Sanna Oikari, Arto Koistinen, Heikki Kröger, Chengjuan Qu, Mikko J Lamm…Mesenchymal stem cells (MSCs) are known to help with tissue repair, partly by releasing tiny packages called extracellular vesicles (EVs). This study investigated the connection between these EVs and hyaluronan (HA), a…
Hyaluronan; CD44; Extracellular vesicle; Stem cell; Filopodia; Hyaluronan synthase - A++2017
Telocytes: Connective tissue repair and communication cells
Leon ChaitowThis commentary highlights a newly identified type of connective tissue cell called a telocyte. We already know that other cells, like fibroblasts, respond to mechanical forces from manual therapy, influencing tissue re…
mechanotransductiontelocytesinterstitial cellsregeneration - B2017
Complex mechanics of the heterogeneous extracellular matrix in cancer
Andrea Malandrino, Michael Mak, Roger D Kammd, Emad MoeendarbaryThis narrative review explores the complex role of the extracellular matrix (ECM), the non-cellular network that provides structural support to tissues. In solid tumors, the ECM becomes highly altered and complex, as ca…
extracellular matrixCell signalingtumor microenvironment - A2017
Reconnecting the Body in Eastern and Western Medicine
Helene M Langevin, Rosa N SchnyerDetails for this 2017 publication, titled 'Reconnecting the Body in Eastern and Western Medicine' by Helene M. Langevin and Rosa N. Schnyer, have not yet been summarized. The title suggests a discussion comparing and in…
acupunctureTCM - A+++2017
Resveratrol Treatment Normalizes the Endothelial Function and Blood Pressure in Ovariectomized Rats
Victor Fabricio, Jorge Camargo Oishi, Bruna Gabriele Biffe, Leandro Dias Gonçalves Ruffoni, Karina Ana da Silva, Keico…This animal study on rats investigated how resveratrol affects blood pressure and vascular function during estrogen deficiency, mimicking post-menopausal conditions. Researchers found that a lack of estrogen led to high…
blood pressureresveratrolPostmenopause - B2017
Sensitivity of ACL Volume and T2* Relaxation Time to Magnetic Resonance Imaging Scan Conditions
Jillian E Beveridge, Edward G Walsh, Martha M Murray, C FlemingThis animal study investigated how different magnetic resonance imaging (MRI) conditions affect measurements of the anterior cruciate ligament (ACL). Researchers in this pig study compared images taken at different reso…
ACL; MRI; T2* relaxometry - C2017
Fibronectin in cell adhesion and migration via N-glycosylation
Cheng-Te Hsiao, Hung-Wei Cheng, Chi-Ming Huang, Hao-Ru Li, Meng-Hsin Ou, Jie-Rong Huang, Kay-Hooi Khoo, Helen Wenshin Y…Fibronectin is a protein in blood plasma that helps cells stick together and move, a process essential for wound healing. This study investigated how a specific chemical modification, called N-glycosylation, affects fib…
wound healingcell migrationFibronectincell adhesion - C2017
Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin
Patricia Paracuellos, Sebastian Kalamajski, Arkadiusz Bonnac, Dominique Bihanc, Richard W. Farndale, Erhard HohenesterFibromodulin and chondroadherin are small proteins that help organize the extracellular matrix. This study examined their 3D structure and how they interact with collagen. Researchers found that while their overall shap…
Cell signalingfibromodulinchondroadherinextra cellular matrix - B2017
Evaluation of fascial manipulation in carpal tunnel syndrome
Marco Pintucci, Marta Imamura, Aurore Thibaut, Lucas M de Exel Nunes, Mylene Mayumi Nagato, Helena H Kaziyama, Satiko T…Details for this study are not yet available. The research, published in 2017, appears to evaluate the effectiveness of Fascial Manipulation® for treating carpal tunnel syndrome. Without an abstract, further details abo…
Fascial manipulationcarpal tunnel syndrome - A+2017
Theoretical study of aerobic vitamin C loss kinetics during commercial heat preservation and storage
Micha PelegThis theoretical study presents a mathematical model to describe how vitamin C is lost in food during commercial heat processing and storage. The model accounts for the degradation of two forms of the vitamin, ascorbic…
Ascorbic acid; Degradation reactions; Dehydroascorbic acid; Kinetics; Storage; Thermal processing. - A++2017
Biological effects of direct and indirect manipulation of the fascial system. Narrative review
Giovanni Parravicini, Andrea BergnaThis narrative review explores the biological effects of manual fascial therapies. While osteopathic manipulative treatment (OMT) is clinically effective, its underlying mechanisms are not fully understood. The authors…
fasciaMyofascial releaseManual TherapyMyofascial manipulation