Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- B2017
Mechanical properties of a collagen fibril under simulated degradation
David C Malaspinaa, Igal Szleifera, Yasin DhaheraThis study used computer simulations to investigate how collagen fibrils lose their strength. Researchers modeled three different types of degradation: the removal of cross-links, surface damage, and damage throughout t…
collagenMolecular dynamicsDegradationMMP - A2017
Semimembranosus Muscle Injuries In Sport. A Practical MRI use for Prognosis
Ramon Balius, Mireia Bossy, Carles Pedret, Lluis Capdevila, Xavier Alomar, Bryan Heiderscheit, Gil RodasThis retrospective study investigated whether MRI scans could help predict recovery time for athletes with injuries to the semimembranosus, one of the hamstring muscles. Researchers analyzed MRI scans from 19 athletes,…
MRIreturn to playsemimembranosushamstring injuries - 1A+2017
Emotions in Motion: Myofascial Interoception
B Bordoni, F MarelliIn this perspective piece, the authors argue that the myofascial system is closely linked to our emotional state. They suggest that manual treatment not only affects the body physically but also activates the interocept…
fasciaManual TherapyMyofascialOsteopathicInteroception - A++2017
Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate
Shilpy Dixit, Joshua P Fessel, Fiona E HarrisonIn this animal study, researchers examined mitochondrial function in a mouse model of Alzheimer's disease and in mice with low levels of vitamin C (ascorbate). The results indicated that both the presence of amyloid (as…
Alzheimer’s disease; mitochondria; oxidative stress; ascorbate; energy production - A+2017
Effects of the menstrual cycle on lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament injury risk: a systematic review
Vivek Balachandar, Jan-Luigi Marciniak, Owen Wall, Chandrika BalachandarThis systematic review evaluated how the menstrual cycle affects lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament (ACL) injury risk in women. The authors found strong evidence that the risk…
Biomechanicsligamentneuromuscularcruciatemenstrual. - A++2017
Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments
Keith BaarMusculoskeletal injuries are a primary reason for time away from sports, partly because our understanding of how training affects tendons and ligaments is limited. This study used engineered ligaments grown in a lab fro…
trainingminimizing injuryreturn to playsupplementation - C2017
S100A4 in cancer progression and metastasis: A systematic review
Fei Fei, Jie Qu, Mingqing Zhang, Yuwei Li, Shiwu ZhangThis systematic review examines the role of the protein S100A4 in cancer progression and metastasis. S100A4 is involved in the epithelial-mesenchymal transition, a key process that allows cancer cells to spread. The aut…
metastasisS100A4malignant tumorepithelial-mesenchymal transition - B2017
All you need to know about the AIP diet
Lana BurgessThis article reviews the Autoimmune Protocol (AIP) diet, which aims to reduce inflammation and relieve symptoms of autoimmune disorders. The diet is based on the idea that problems with the gut wall, sometimes called 'l…
inflammationAutoimmune protocolautoimmune disease - A2017
Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale
Charles Reilly, Donald E IngberA project that began as an artistic endeavor to create an entertaining short film about fertilization led to the development of a new scientific simulation tool. By integrating physics-based animation software from the…
Tensegritysimulationanimationaxonemedynein - A+2017
The nature and biology of basement membranes
Ambra Pozzi, Peter D Yurchenco, Renato V IozzoThis review article discusses the nature and biology of basement membranes. These are thin, flexible sheets of tissue that line and separate different structures in the body. Once thought to be just passive scaffolding,…
Collagen; laminin; heparan sulfate proteoglycan; discoidin domain receptor; integrin - A+++2017
Resveratrol supplementation reduces pain experience by postmenopausal women
Rachel H X Wong, Hamish M Evans, Peter R C HoweThis randomized, double-blind, placebo-controlled study investigated whether resveratrol supplementation could reduce pain and improve well-being in postmenopausal women. Over 14 weeks, participants taking 75 mg of resv…
Resveratrolpolyphenolemenopause - A+++2017
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J…This randomized controlled trial examined the effects of a fasting-mimicking diet (FMD) on risk factors for age-related diseases in 100 healthy participants. For five consecutive days each month over a three-month perio…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; cancer; diabetes; cardiovascular disease