Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2022
Fetal Fascial Reinforcement Development: From “a White Tablet” to a Sculpted Precise Organization by Movement
Carmelo Pirri, Lucia Petrelli, Albert Pérez-Bellmunt, Sara Ortiz-Miguel, Caterina Fede, Raffaele De Caro, Maribel Migue…This study examined the development of fascia and retinacula (connective tissue reinforcements) in six human fetuses between 24 and 40 weeks of gestation. The researchers found that deep fascia initially lacks organized…
fetus; fascia development; retinacula; gross functional movements - A++2022
The deep fascia and its role in chronic pain and pathological conditions: A review
Flemming Kondrup, Nathaly Gaudreault, Gabriel VenneThis narrative review explores the deep fascia, a three-dimensional continuum of connective tissue surrounding muscles, nerves, and blood vessels. The researchers identified five common conditions associated with fascia…
anatomy; chronic pain; deep fascia; fasciitis; inflammation; innervation. - A++2022
Risk Factors of Postpartum Depression
Iris Agrawal, Ashok M Mehendale, Ritika MalhotraThis literature review examines the risk factors for postpartum depression (PPD), a condition affecting 10–15% of new mothers globally. The research suggests that factors such as a history of psychiatric illness, lack o…
clinical features; history of depression; post-natal mother; postnatal depression; postpartum care; postpartum depression; postpartum mental health; postpartum mothers; risk factors; spousal support. - A+++2022
Hyaluronan homeostasis and its role in pain and muscle stiffness
Adam Amir, Soo Kim, Antonio Stecco, Michael P Jankowski, Preeti RaghavanThis narrative review explores the role of hyaluronan (HA) in the musculoskeletal system. HA is a key component of the extracellular matrix in muscles and fascia, where it normally functions as a lubricant and shock abs…
hyaluronanpainmuscle stiffness - A+++2022
Performance of Swedish Warmblood fragile foal syndrome carriers and breeding prospects
Michela Ablondi, Martin Johnsson, Susanne Eriksson, Alberto Sabbioni, Åsa Gelinder Viklund, Sofia MikkoThis research article investigated the prevalence of Warmblood fragile foal syndrome (WFFS) in Swedish Warmblood horses and its potential link to performance. WFFS is a lethal genetic defect affecting collagen stability…
FFSWFFS - A++2022
Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation
Hailin Liu, Jialing Hu, Qingcui Zheng, Xiaojin Feng, Fenfang Zhan, Xifeng Wang, Guohai Xu, Fuzhou HuaThis narrative review explores the role of Piezo1 ion channels as mechanical sensors that link physical force to chronic inflammation. Piezo1 channels open in response to stimuli like pressure, stretch, and tissue stiff…
Ca 2+; MSc; Piezo1; chronic inflammation; mechanical force; pharmacology. - A++2022
Mechanosensing by Piezo1 and its implications for physiology and various pathologies
Austin Lai, Charles D Cox, Nadia Chandra Sekar, Peter Thurgood, Anthony Jaworowski, Karlheinz Peter, Sara BaratchiThis narrative review explores Piezo1, a specialized ion channel that senses mechanical pressure and converts it into biological signals within the body. These channels are widely distributed in tissues such as blood ve…
Piezo1; mechanoreceptor; mechanosensitive ion channel; mechanotransduction; shear stress. - A+++2022
The Effects of Aging on the Intramuscular Connective Tissue
Caterina Fede, Chenglei Fan, Carmelo Pirri, Lucia Petrelli, Carlo Biz, Andrea Porzionato, Veronica Macchi, Raffaele De…This study investigated how intramuscular connective tissue changes with age in both humans and mice. Researchers found that the amount of stiff collagen (Type I) increases significantly with age, while levels of hyalur…
aging; collagen; extracellular matrix; hyaluronan; intramuscular connective tissue; motor control; muscle - A+++2022
Fascial Innervation: A Systematic Review of the Literature
Vidina Suarez-Rodriguez, Caterina Fede, Carmelo Pirri, Lucia Petrelli, Juan Francisco Loro-Ferrer, David Rodriguez-Ruiz…This systematic review examines current evidence regarding the innervation of deep fascia and its potential role in myofascial pain. The findings suggest that fascia is not merely an inert wrapping but a sophisticated s…
fascia; innervation; nociceptor; pain - A+++2022
Magnetic fields induce exclusion zones in water
Valery Shalatonin, Gerald H PollackThis study explores how static magnetic fields influence water by creating "exclusion zones" (EZ), areas where particles are pushed away from the magnet's poles. Researchers observed that these zones form at both the no…
EZ waterfourth phase of waterexclusion zonesmagnetic fields - A+++2022
Effect of Ground and Raised Poles on Kinematics of the Walk
Vicki A Walker, Carolyne A Tranquillle, Russell MacKechnie-Guire, Jo Spear, Richard Newton, Rachel C MurrayThis study investigated how horses are affected by walking over ground poles and raised poles compared to walking on flat ground. The results suggest that polework increases joint range of motion through enhanced limb f…
Equine; Gait analysis; IMU; Polework; Rehabilitation - A+++2022
Making Connections to Improve Health Outcomes
Helene M LangevinIn this editorial, Helene M. Langevin discusses the importance of whole person health, viewing the individual as an interconnected system rather than a collection of isolated organs. She argues that biomedical research…
complementary and alternative medicine; integrative medicine; treatment and prevention