Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesHyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory
This narrative review explores hyaluronic acid (HA), a naturally occurring substance found in connective tissues and synovial fluid. HA is essential for joint lubrication and viscoelasticity, but its concentration and m…
Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2
In this study using cell cultures and animal models, researchers investigated how vitamin C might inhibit the spread of triple-negative breast cancer (TNBC). They found that vitamin C, at concentrations achievable throu…
Vitamin C and Neutrophil Function: Findings from Randomized Controlled Trials
This systematic review examined how vitamin C supplementation affects neutrophils, a key type of immune cell. Researchers analyzed 16 randomized controlled trials that measured neutrophil functions like their ability to…
Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts
This laboratory study investigated how cannabidiol (CBD) influences inflammatory responses in lung epithelial cells, fibroblasts, and immune cells. The researchers found that CBD can reduce inflammation triggered by ext…
Improving the New Definition of Fascial System
This narrative review proposes expanding the definition of the fascial system to include bone tissue. The author argues that bone, a specialized form of connective tissue, shares the same embryological origins as other…
Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of combining resistance training with a daily intake of 15 grams of specific collagen peptides in premenopausal women. Over 12 weeks, participants trained three…
Fascia Is Able to Actively Contract and May Thereby Influence Musculoskeletal Dynamics: A Histochemical and Mechanographic Investigation
This study investigated whether fascia can actively contract, challenging the traditional view of it as a passive tissue. Researchers examined human and rat fascial samples for the presence of contractile cells called m…
Induced lumbosacral radicular symptom referral patterns: a descriptive study
This observational study investigated actual pain patterns caused by irritating specific nerve roots in the lower back. Clinicians often use standard 'dermatome' maps to diagnose the source of radiating leg pain, but pa…
Chronic low back pain influences trunk neuromuscular control during unstable sitting among persons with lower-limb loss
People with lower-limb loss are at a higher risk for chronic low back pain. This study investigated whether trunk postural control differs between those with and without pain in this population. Researchers had men with…
Overuse Injury: The Result of Pathologically Altered Myofascial Force Transmission?
In this narrative review, the authors propose a new perspective on overuse injuries. Traditionally, therapy focuses on the site of pain, viewing the injury as the result of local, repetitive microdamage. The authors hyp…
The secret life of proteins
The traditional scientific view has long held that single protein molecules are electrical insulators. However, a recent discovery overturns this belief, suggesting instead that proteins are strong electrical conductors…
Vitamin C: an essential “stress hormone” during sepsis
The body's stress response involves hormones like cortisol and catecholamines, but in most mammals, it also includes increased production of vitamin C. These substances work together to protect the body from damage duri…