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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 25–36 of 36 studies · page 3/3mechanotransductionWith summary
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  1. A
    2007

    Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering

    Kevin K Parker, Donald E Ingber

    This narrative review explores the challenges of engineering artificial heart tissue. The heart functions across vast scales of time and space, from tiny ion channels to the whole organ's pumping action. The authors sug…

    fasciaextracellular matrixcytoskeletonmechanotransductionmyocardial cell
  2. A
    2006

    Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of a- and b-actin

    Helene M Langevin, Kirsten N Storch, Marilyn J Cipolla, Sheryl L White, Thomas R Buttolph, Douglas J Taatjes

    Researchers investigated how fibroblasts, the primary cells in connective tissue, respond to mechanical stretching. In this ex vivo study, they stretched samples of subcutaneous tissue for 30 minutes and observed change…

    fasciamechanical stressfibroblastmechanotransductionSubcutaneous tissue
  3. A
    2006

    Subcutaneous Tissue Fibroblast Cytoskeletal Remodeling Induced by Acupuncture: Evidence for a Mechanotransduction-Based Mechanism

    Helene M Langevin, Nicole A Bouffard, Gary J Badger, David L Churchill, Alan K Howe

    In this mouse tissue study, researchers investigated how rotating an acupuncture needle affects fibroblasts in the connective tissue under the skin. They found that rotation caused the fibroblasts to actively change sha…

    fasciacollagenfibroblastcytoskeletonmechanotransduction
  4. A
    2006

    Mechanisms of Mechanotransduction

    A Wayne Orr, Brian P Helmke, Brett R Blackman, Martin A Schwartz

    This review describes mechanotransduction, the process by which cells sense and respond to physical forces. The researchers explain that nearly all living organisms, from bacteria to humans, are sensitive to mechanical…

    extracellular matrixcytoskeletonmechanotransductionfocal adhesion
  5. A
    2005

    Mechanical control of tissue growth: Function follows form

    Donald E Ingber

    The full text of this 2005 article has not yet been summarized by our team. The title, "Mechanical control of tissue growth: Function follows form," suggests a focus on how mechanical forces influence the development an…

    fasciamechanotransductionmorphogenesis
  6. A
    2005

    Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo

    H M Langevin, N A Bouffard, G J Badger, J C Iatridis, A K Howe

    In this animal study, researchers investigated how fibroblasts, the primary cells in connective tissue, respond to mechanical stretch. By stretching subcutaneous tissue from mice, both in tissue samples (ex vivo) and in…

    Connective tissueTensegritymechanotransductionmusculoskeletal manipulationsacupuncture
  7. A
    2005

    Cell tension, matrix mechanics, and cancer development

    Sui Huang, Donald E Ingber

    Doctors can often diagnose cancer by feeling for tissue stiffness, and this study explores how this mechanical property contributes to cancer development. The researchers suggest that the stiff extracellular matrix in t…

    extracellular matrixcancercytoskeletonmechanotransduction
  8. A
    2004

    Integrins in Mechanotransduction

    Akira Katsumi, A Wayne Orr, Eleni Tzima, Martin Alexander Schwartz

    This 2004 review article examines how cells sense and respond to physical forces, a process known as mechanotransduction. The authors focus on integrins, a class of proteins that anchor cells to their surroundings and a…

    mechanotransductionIntegrins
  9. A
    2003

    Mechanobiology and diseases of mechanotransduction

    Donald E Ingber

    This 2003 article argues that medicine often overlooks the physical and mechanical aspects of disease, focusing instead on genetics. The author reviews how physical forces and the extracellular matrix are vital for norm…

    extracellular matrixcytoskeletonmechanotransductionIntegrinstissue engineering
  10. A
    2003

    Tensegrity II. How structural networks influence cellular information processing networks

    Donald E Ingber

    This theoretical article, the second in a two-part series, explores how a cell's physical structure influences its internal signaling and behavior. It builds on the "tensegrity" model, which describes the cell's skeleto…

    BioinformaticsmechanotransductionIntegrinsmechanobiologyBiocomplexity
  11. A
    2001

    Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture

    Helene M Langevin, David L Churchill, Marilyn J Cipolla

    This paper proposes a hypothesis for how acupuncture might work. The authors focus on the "de qi" sensation, which includes the acupuncturist feeling a "needle grasp" in the tissue. They suggest that when an acupuncture…

    collagenmechanotransductionmeridian
  12. A
    1999

    Tensegrity and mechanoregulation: from skeleton to cytoskeleton

    Christopher S Chen, Donald E Ingber

    This review article explores how mechanical forces are transmitted from the whole body down to individual cells. The authors propose that a design principle called "tensegrity," which uses continuous tension and local c…

    extracellular matrixTensegritycytoskeletonmechanotransductionIntegrins